P42261: Glutamate receptor 1

General Information

Protein names	- Glutamate receptor 1 - GluR-1 - AMPA-selective glutamate receptor 1 - GluR-A - GluR-K1 - Glutamate receptor ionotropic, AMPA 1 - GluA1
Gene names	GRIA1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P42261

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Flip of Glutamate receptor 1 - Isoform 3 of Glutamate receptor 1 - Isoform 4 of Glutamate receptor 1 - Isoform 5 of Glutamate receptor 1 - Isoform 6 of Glutamate receptor 1

Sequence View

        10         20         30         40         50         60
MQHIFAFFCT GFLGAVVGAN FPNNIQIGGL FPNQQSQEHA AFRFALSQLT EPPKLLPQID
        70         80         90        100        110        120
IVNISDSFEM TYRFCSQFSK GVYAIFGFYE RRTVNMLTSF CGALHVCFIT PSFPVDTSNQ
       130        140        150        160        170        180
FVLQLRPELQ DALISIIDHY KWQKFVYIYD ADRGLSVLQK VLDTAAEKNW QVTAVNILTT
       190        200        210        220        230        240
TEEGYRMLFQ DLEKKKERLV VVDCESERLN AILGQIIKLE KNGIGYHYIL ANLGFMDIDL
       250        260        270        280        290        300
NKFKESGANV TGFQLVNYTD TIPAKIMQQW KNSDARDHTR VDWKRPKYTS ALTYDGVKVM
       310        320        330        340        350        360
AEAFQSLRRQ RIDISRRGNA GDCLANPAVP WGQGIDIQRA LQQVRFEGLT GNVQFNEKGR
       370        380        390        400        410        420
RTNYTLHVIE MKHDGIRKIG YWNEDDKFVP AATDAQAGGD NSSVQNRTYI VTTILEDPYV
       430        440        450        460        470        480
MLKKNANQFE GNDRYEGYCV ELAAEIAKHV GYSYRLEIVS DGKYGARDPD TKAWNGMVGE
       490        500        510        520        530        540
LVYGRADVAV APLTITLVRE EVIDFSKPFM SLGISIMIKK PQKSKPGVFS FLDPLAYEIW
       550        560        570        580        590        600
MCIVFAYIGV SVVLFLVSRF SPYEWHSEEF EEGRDQTTSD QSNEFGIFNS LWFSLGAFMQ
       610        620        630        640        650        660
QGCDISPRSL SGRIVGGVWW FFTLIIISSY TANLAAFLTV ERMVSPIESA EDLAKQTEIA
       670        680        690        700        710        720
YGTLEAGSTK EFFRRSKIAV FEKMWTYMKS AEPSVFVRTT EEGMIRVRKS KGKYAYLLES
       730        740        750        760        770        780
TMNEYIEQRK PCDTMKVGGN LDSKGYGIAT PKGSALRNPV NLAVLKLNEQ GLLDKLKNKW
       790        800        810        820        830        840
WYDKGECGSG GGDSKDKTSA LSLSNVAGVF YILIGGLGLA MLVALIEFCY KSRSESKRMK
       850        860        870        880        890        900
GFCLIPQQSI NEAIRTSTLP RNSGAGASSG GSGENGRVVS HDFPKSMQSI PCMSHSSGMP

LGATGL         10         20         30         40         50         60
MQHIFAFFCT GFLGAVVGAN FPNNIQIGGL FPNQQSQEHA AFRFALSQLT EPPKLLPQID
        70         80         90        100        110        120
IVNISDSFEM TYRFCSQFSK GVYAIFGFYE RRTVNMLTSF CGALHVCFIT PSFPVDTSNQ
       130        140        150        160        170        180
FVLQLRPELQ DALISIIDHY KWQKFVYIYD ADRGLSVLQK VLDTAAEKNW QVTAVNILTT
       190        200        210        220        230        240
TEEGYRMLFQ DLEKKKERLV VVDCESERLN AILGQIIKLE KNGIGYHYIL ANLGFMDIDL
       250        260        270        280        290        300
NKFKESGANV TGFQLVNYTD TIPAKIMQQW KNSDARDHTR VDWKRPKYTS ALTYDGVKVM
       310        320        330        340        350        360
AEAFQSLRRQ RIDISRRGNA GDCLANPAVP WGQGIDIQRA LQQVRFEGLT GNVQFNEKGR
       370        380        390        400        410        420
RTNYTLHVIE MKHDGIRKIG YWNEDDKFVP AATDAQAGGD NSSVQNRTYI VTTILEDPYV
       430        440        450        460        470        480
MLKKNANQFE GNDRYEGYCV ELAAEIAKHV GYSYRLEIVS DGKYGARDPD TKAWNGMVGE
       490        500        510        520        530        540
LVYGRADVAV APLTITLVRE EVIDFSKPFM SLGISIMIKK PQKSKPGVFS FLDPLAYEIW
       550        560        570        580        590        600
MCIVFAYIGV SVVLFLVSRF SPYEWHSEEF EEGRDQTTSD QSNEFGIFNS LWFSLGAFMQ
       610        620        630        640        650        660
QGCDISPRSL SGRIVGGVWW FFTLIIISSY TANLAAFLTV ERMVSPIESA EDLAKQTEIA
       670        680        690        700        710        720
YGTLEAGSTK EFFRRSKIAV FEKMWTYMKS AEPSVFVRTT EEGMIRVRKS KGKYAYLLES
       730        740        750        760        770        780
TMNEYIEQRK PCDTMKVGGN LDSKGYGIAT PKGSALRNPV NLAVLKLNEQ GLLDKLKNKW
       790        800        810        820        830        840
WYDKGECGSG GGDSKDKTSA LSLSNVAGVF YILIGGLGLA MLVALIEFCY KSRSESKRMK
       850        860        870        880        890        900
GFCLIPQQSI NEAIRTSTLP RNSGAGASSG GSGENGRVVS HDFPKSMQSI PCMSHSSGMP

LGATGL         10         20         30         40         50         60
MQHIFAFFCT GFLGAVVGAN FPNNIQIGGL FPNQQSQEHA AFRFALSQLT EPPKLLPQID
        70         80         90        100        110        120
IVNISDSFEM TYRFCSQFSK GVYAIFGFYE RRTVNMLTSF CGALHVCFIT PSFPVDTSNQ
       130        140        150        160        170        180
FVLQLRPELQ DALISIIDHY KWQKFVYIYD ADRGLSVLQK VLDTAAEKNW QVTAVNILTT
       190        200        210        220        230        240
TEEGYRMLFQ DLEKKKERLV VVDCESERLN AILGQIIKLE KNGIGYHYIL ANLGFMDIDL
       250        260        270        280        290        300
NKFKESGANV TGFQLVNYTD TIPAKIMQQW KNSDARDHTR VDWKRPKYTS ALTYDGVKVM
       310        320        330        340        350        360
AEAFQSLRRQ RIDISRRGNA GDCLANPAVP WGQGIDIQRA LQQVRFEGLT GNVQFNEKGR
       370        380        390        400        410        420
RTNYTLHVIE MKHDGIRKIG YWNEDDKFVP AATDAQAGGD NSSVQNRTYI VTTILEDPYV
       430        440        450        460        470        480
MLKKNANQFE GNDRYEGYCV ELAAEIAKHV GYSYRLEIVS DGKYGARDPD TKAWNGMVGE
       490        500        510        520        530        540
LVYGRADVAV APLTITLVRE EVIDFSKPFM SLGISIMIKK PQKSKPGVFS FLDPLAYEIW
       550        560        570        580        590        600
MCIVFAYIGV SVVLFLVSRF SPYEWHSEEF EEGRDQTTSD QSNEFGIFNS LWFSLGAFMQ
       610        620        630        640        650        660
QGCDISPRSL SGRIVGGVWW FFTLIIISSY TANLAAFLTV ERMVSPIESA EDLAKQTEIA
       670        680        690        700        710        720
YGTLEAGSTK EFFRRSKIAV FEKMWTYMKS AEPSVFVRTT EEGMIRVRKS KGKYAYLLES
       730        740        750        760        770        780
TMNEYIEQRK PCDTMKVGGN LDSKGYGIAT PKGSALRNPV NLAVLKLNEQ GLLDKLKNKW
       790        800        810        820        830        840
WYDKGECGSG GGDSKDKTSA LSLSNVAGVF YILIGGLGLA MLVALIEFCY KSRSESKRMK
       850        860        870        880        890        900
GFCLIPQQSI NEAIRTSTLP RNSGAGASSG GSGENGRVVS HDFPKSMQSI PCMSHSSGMP

LGATGL         10         20         30         40         50         60
MQHIFAFFCT GFLGAVVGAN FPNNIQIGGL FPNQQSQEHA AFRFALSQLT EPPKLLPQID
        70         80         90        100        110        120
IVNISDSFEM TYRFCSQFSK GVYAIFGFYE RRTVNMLTSF CGALHVCFIT PSFPVDTSNQ
       130        140        150        160        170        180
FVLQLRPELQ DALISIIDHY KWQKFVYIYD ADRGLSVLQK VLDTAAEKNW QVTAVNILTT
       190        200        210        220        230        240
TEEGYRMLFQ DLEKKKERLV VVDCESERLN AILGQIIKLE KNGIGYHYIL ANLGFMDIDL
       250        260        270        280        290        300
NKFKESGANV TGFQLVNYTD TIPAKIMQQW KNSDARDHTR VDWKRPKYTS ALTYDGVKVM
       310        320        330        340        350        360
AEAFQSLRRQ RIDISRRGNA GDCLANPAVP WGQGIDIQRA LQQVRFEGLT GNVQFNEKGR
       370        380        390        400        410        420
RTNYTLHVIE MKHDGIRKIG YWNEDDKFVP AATDAQAGGD NSSVQNRTYI VTTILEDPYV
       430        440        450        460        470        480
MLKKNANQFE GNDRYEGYCV ELAAEIAKHV GYSYRLEIVS DGKYGARDPD TKAWNGMVGE
       490        500        510        520        530        540
LVYGRADVAV APLTITLVRE EVIDFSKPFM SLGISIMIKK PQKSKPGVFS FLDPLAYEIW
       550        560        570        580        590        600
MCIVFAYIGV SVVLFLVSRF SPYEWHSEEF EEGRDQTTSD QSNEFGIFNS LWFSLGAFMQ
       610        620        630        640        650        660
QGCDISPRSL SGRIVGGVWW FFTLIIISSY TANLAAFLTV ERMVSPIESA EDLAKQTEIA
       670        680        690        700        710        720
YGTLEAGSTK EFFRRSKIAV FEKMWTYMKS AEPSVFVRTT EEGMIRVRKS KGKYAYLLES
       730        740        750        760        770        780
TMNEYIEQRK PCDTMKVGGN LDSKGYGIAT PKGSALRNPV NLAVLKLNEQ GLLDKLKNKW
       790        800        810        820        830        840
WYDKGECGSG GGDSKDKTSA LSLSNVAGVF YILIGGLGLA MLVALIEFCY KSRSESKRMK
       850        860        870        880        890        900
GFCLIPQQSI NEAIRTSTLP RNSGAGASSG GSGENGRVVS HDFPKSMQSI PCMSHSSGMP

LGATGL         10         20         30         40         50         60
MQHIFAFFCT GFLGAVVGAN FPNNIQIGGL FPNQQSQEHA AFRFALSQLT EPPKLLPQID
        70         80         90        100        110        120
IVNISDSFEM TYRFCSQFSK GVYAIFGFYE RRTVNMLTSF CGALHVCFIT PSFPVDTSNQ
       130        140        150        160        170        180
FVLQLRPELQ DALISIIDHY KWQKFVYIYD ADRGLSVLQK VLDTAAEKNW QVTAVNILTT
       190        200        210        220        230        240
TEEGYRMLFQ DLEKKKERLV VVDCESERLN AILGQIIKLE KNGIGYHYIL ANLGFMDIDL
       250        260        270        280        290        300
NKFKESGANV TGFQLVNYTD TIPAKIMQQW KNSDARDHTR VDWKRPKYTS ALTYDGVKVM
       310        320        330        340        350        360
AEAFQSLRRQ RIDISRRGNA GDCLANPAVP WGQGIDIQRA LQQVRFEGLT GNVQFNEKGR
       370        380        390        400        410        420
RTNYTLHVIE MKHDGIRKIG YWNEDDKFVP AATDAQAGGD NSSVQNRTYI VTTILEDPYV
       430        440        450        460        470        480
MLKKNANQFE GNDRYEGYCV ELAAEIAKHV GYSYRLEIVS DGKYGARDPD TKAWNGMVGE
       490        500        510        520        530        540
LVYGRADVAV APLTITLVRE EVIDFSKPFM SLGISIMIKK PQKSKPGVFS FLDPLAYEIW
       550        560        570        580        590        600
MCIVFAYIGV SVVLFLVSRF SPYEWHSEEF EEGRDQTTSD QSNEFGIFNS LWFSLGAFMQ
       610        620        630        640        650        660
QGCDISPRSL SGRIVGGVWW FFTLIIISSY TANLAAFLTV ERMVSPIESA EDLAKQTEIA
       670        680        690        700        710        720
YGTLEAGSTK EFFRRSKIAV FEKMWTYMKS AEPSVFVRTT EEGMIRVRKS KGKYAYLLES
       730        740        750        760        770        780
TMNEYIEQRK PCDTMKVGGN LDSKGYGIAT PKGSALRNPV NLAVLKLNEQ GLLDKLKNKW
       790        800        810        820        830        840
WYDKGECGSG GGDSKDKTSA LSLSNVAGVF YILIGGLGLA MLVALIEFCY KSRSESKRMK
       850        860        870        880        890        900
GFCLIPQQSI NEAIRTSTLP RNSGAGASSG GSGENGRVVS HDFPKSMQSI PCMSHSSGMP

LGATGL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P42261-1-unknown	MQHIFA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76431
P42261-1-unknown	MQHIFA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76432
P42261-19-unknown	ANFPNN...	19	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P42261-19-unknown	ANFPNN...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112084
P42261-19-unknown	ANFPNN...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112085
P42261-70-unknown	MTYRFC...	70	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76433
P42261-70-unknown	MTYRFC...	70	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt104093
P42261-70-unknown	MTYRFC...	70	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt104091
P42261-70-unknown	MTYRFC...	70	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt104092
P42261-883-unknown	FPKSMQ...	883	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3065
P42261-883-unknown	FPKSMQ...	883	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156499
P42261-883-unknown	FPKSMQ...	883	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156553
P42261-883-unknown	FPKSMQ...	883	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156801
P42261-883-unknown	FPKSMQ...	883	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156839
P42261-883-unknown	FPKSMQ...	883	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156840

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VVSHDF	882	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3065
...VVSHDF	882	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139983
...VVSHDF	882	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140037
...VVSHDF	882	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140293
...VVSHDF	882	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140335
...VVSHDF	882	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140336
...GATGL	906	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GATGL	906	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72050
...GATGL	906	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72051
...GATGL	906	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72049
...GATGL	906	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72052
...GATGL	906	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72053

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP8_HUMAN	882	SHDF.\|.FPKS	inferred from experiment	unknown	MEROPS	Rogers SW	Meyer EL et al.:Nicotine preconditioning antago... (C14.009)	11751897,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)