TopFIND 4.0

P42679: Megakaryocyte-associated tyrosine-protein kinase

General Information

Protein names
- Megakaryocyte-associated tyrosine-protein kinase
- 2.7.10.2
- CSK homologous kinase
- CHK
- Hematopoietic consensus tyrosine-lacking kinase
- Protein kinase HYL
- Tyrosine-protein kinase CTK
Gene names MATK
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P42679

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAGRGSLVSW RAFHGCDSAE ELPRVSPRFL RAWHPPPVSA RMPTRRWAPG TQCITKCEHT 
        70         80         90        100        110        120 
RPKPGELAFR KGDVVTILEA CENKSWYRVK HHTSGQEGLL AAGALREREA LSADPKLSLM 
       130        140        150        160        170        180 
PWFHGKISGQ EAVQQLQPPE DGLFLVRESA RHPGDYVLCV SFGRDVIHYR VLHRDGHLTI 
       190        200        210        220        230        240 
DEAVFFCNLM DMVEHYSKDK GAICTKLVRP KRKHGTKSAE EELARAGWLL NLQHLTLGAQ 
       250        260        270        280        290        300 
IGEGEFGAVL QGEYLGQKVA VKNIKCDVTA QAFLDETAVM TKMQHENLVR LLGVILHQGL 
       310        320        330        340        350        360 
YIVMEHVSKG NLVNFLRTRG RALVNTAQLL QFSLHVAEGM EYLESKKLVH RDLAARNILV 
       370        380        390        400        410        420 
SEDLVAKVSD FGLAKAERKG LDSSRLPVKW TAPEALKHGK FTSKSDVWSF GVLLWEVFSY 
       430        440        450        460        470        480 
GRAPYPKMSL KEVSEAVEKG YRMEPPEGCP GPVHVLMSSC WEAEPARRPP FRKLAEKLAR 
       490        500    
ELRSAGAPAS VSGQDADGST SPRSQEP

Isoforms

- Isoform 2 of Megakaryocyte-associated tyrosine-protein kinase - Isoform 3 of Megakaryocyte-associated tyrosine-protein kinase

Sequence View

        10         20         30         40         50         60 
MAGRGSLVSW RAFHGCDSAE ELPRVSPRFL RAWHPPPVSA RMPTRRWAPG TQCITKCEHT 
        70         80         90        100        110        120 
RPKPGELAFR KGDVVTILEA CENKSWYRVK HHTSGQEGLL AAGALREREA LSADPKLSLM 
       130        140        150        160        170        180 
PWFHGKISGQ EAVQQLQPPE DGLFLVRESA RHPGDYVLCV SFGRDVIHYR VLHRDGHLTI 
       190        200        210        220        230        240 
DEAVFFCNLM DMVEHYSKDK GAICTKLVRP KRKHGTKSAE EELARAGWLL NLQHLTLGAQ 
       250        260        270        280        290        300 
IGEGEFGAVL QGEYLGQKVA VKNIKCDVTA QAFLDETAVM TKMQHENLVR LLGVILHQGL 
       310        320        330        340        350        360 
YIVMEHVSKG NLVNFLRTRG RALVNTAQLL QFSLHVAEGM EYLESKKLVH RDLAARNILV 
       370        380        390        400        410        420 
SEDLVAKVSD FGLAKAERKG LDSSRLPVKW TAPEALKHGK FTSKSDVWSF GVLLWEVFSY 
       430        440        450        460        470        480 
GRAPYPKMSL KEVSEAVEKG YRMEPPEGCP GPVHVLMSSC WEAEPARRPP FRKLAEKLAR 
       490        500    
ELRSAGAPAS VSGQDADGST SPRSQEP         10         20         30         40         50         60 
MAGRGSLVSW RAFHGCDSAE ELPRVSPRFL RAWHPPPVSA RMPTRRWAPG TQCITKCEHT 
        70         80         90        100        110        120 
RPKPGELAFR KGDVVTILEA CENKSWYRVK HHTSGQEGLL AAGALREREA LSADPKLSLM 
       130        140        150        160        170        180 
PWFHGKISGQ EAVQQLQPPE DGLFLVRESA RHPGDYVLCV SFGRDVIHYR VLHRDGHLTI 
       190        200        210        220        230        240 
DEAVFFCNLM DMVEHYSKDK GAICTKLVRP KRKHGTKSAE EELARAGWLL NLQHLTLGAQ 
       250        260        270        280        290        300 
IGEGEFGAVL QGEYLGQKVA VKNIKCDVTA QAFLDETAVM TKMQHENLVR LLGVILHQGL 
       310        320        330        340        350        360 
YIVMEHVSKG NLVNFLRTRG RALVNTAQLL QFSLHVAEGM EYLESKKLVH RDLAARNILV 
       370        380        390        400        410        420 
SEDLVAKVSD FGLAKAERKG LDSSRLPVKW TAPEALKHGK FTSKSDVWSF GVLLWEVFSY 
       430        440        450        460        470        480 
GRAPYPKMSL KEVSEAVEKG YRMEPPEGCP GPVHVLMSSC WEAEPARRPP FRKLAEKLAR 
       490        500    
ELRSAGAPAS VSGQDADGST SPRSQEP



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Evidence Codes:


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Biological System:


Protease Assignment Confidence:


Evidence Names:


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Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P42679-1-unknown MAGRGS... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P42679-42-unknown MPTRRW... 42 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt80475
    P42679-42-unknown MPTRRW... 42 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt101059

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)