TopFIND 4.0

P42771: Cyclin-dependent kinase inhibitor 2A {ECO:0000312|HGNC:HGNC:1787}

General Information

Protein names
- Cyclin-dependent kinase inhibitor 2A {ECO:0000312|HGNC:HGNC:1787}
- Cyclin-dependent kinase 4 inhibitor A
- CDK4I
- Multiple tumor suppressor 1
- MTS-1
- p16-INK4a
- p16-INK4
- p16INK4A
Gene names CDKN2A
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P42771

4

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MEPAAGSSME PSADWLATAA ARGRVEEVRA LLEAGALPNA PNSYGRRPIQ VMMMGSARVA 
        70         80         90        100        110        120 
ELLLLHGAEP NCADPATLTR PVHDAAREGF LDTLVVLHRA GARLDVRDAW GRLPVDLAEE 
       130        140        150    
LGHRDVARYL RAAAGGTRGS NHARIDAAEG PSDIPD

Isoforms

- Isoform 2 of Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 - Isoform 3 of Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 - Isoform 5 of Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 - Isoform 2 of Cyclin-dependent kinase inhibitor 2A - Isoform 3 of Cyclin-dependent kinase inhibitor 2A - Isoform 5 of Cyclin-dependent kinase inhibitor 2A

Sequence View

        10         20         30         40         50         60 
MEPAAGSSME PSADWLATAA ARGRVEEVRA LLEAGALPNA PNSYGRRPIQ VMMMGSARVA 
        70         80         90        100        110        120 
ELLLLHGAEP NCADPATLTR PVHDAAREGF LDTLVVLHRA GARLDVRDAW GRLPVDLAEE 
       130        140        150    
LGHRDVARYL RAAAGGTRGS NHARIDAAEG PSDIPD         10         20         30         40         50         60 
MEPAAGSSME PSADWLATAA ARGRVEEVRA LLEAGALPNA PNSYGRRPIQ VMMMGSARVA 
        70         80         90        100        110        120 
ELLLLHGAEP NCADPATLTR PVHDAAREGF LDTLVVLHRA GARLDVRDAW GRLPVDLAEE 
       130        140        150    
LGHRDVARYL RAAAGGTRGS NHARIDAAEG PSDIPD         10         20         30         40         50         60 
MEPAAGSSME PSADWLATAA ARGRVEEVRA LLEAGALPNA PNSYGRRPIQ VMMMGSARVA 
        70         80         90        100        110        120 
ELLLLHGAEP NCADPATLTR PVHDAAREGF LDTLVVLHRA GARLDVRDAW GRLPVDLAEE 
       130        140        150    
LGHRDVARYL RAAAGGTRGS NHARIDAAEG PSDIPD         10         20         30         40         50         60 
MEPAAGSSME PSADWLATAA ARGRVEEVRA LLEAGALPNA PNSYGRRPIQ VMMMGSARVA 
        70         80         90        100        110        120 
ELLLLHGAEP NCADPATLTR PVHDAAREGF LDTLVVLHRA GARLDVRDAW GRLPVDLAEE 
       130        140        150    
LGHRDVARYL RAAAGGTRGS NHARIDAAEG PSDIPD         10         20         30         40         50         60 
MEPAAGSSME PSADWLATAA ARGRVEEVRA LLEAGALPNA PNSYGRRPIQ VMMMGSARVA 
        70         80         90        100        110        120 
ELLLLHGAEP NCADPATLTR PVHDAAREGF LDTLVVLHRA GARLDVRDAW GRLPVDLAEE 
       130        140        150    
LGHRDVARYL RAAAGGTRGS NHARIDAAEG PSDIPD         10         20         30         40         50         60 
MEPAAGSSME PSADWLATAA ARGRVEEVRA LLEAGALPNA PNSYGRRPIQ VMMMGSARVA 
        70         80         90        100        110        120 
ELLLLHGAEP NCADPATLTR PVHDAAREGF LDTLVVLHRA GARLDVRDAW GRLPVDLAEE 
       130        140        150    
LGHRDVARYL RAAAGGTRGS NHARIDAAEG PSDIPD



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...SDIPD 156 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...SDIPD 156 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt65542

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)