P42898: Methylenetetrahydrofolate reductase {ECO:0000305}

General Information

Protein names	- Methylenetetrahydrofolate reductase {ECO:0000305} - 1.5.1.20 {ECO:0000269\|PubMed:25736335}
Gene names	MTHFR
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P42898

1 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVNEARGNSS LNPCLEGSAS SGSESSKDSS RCSTPGLDPE RHERLREKMR RRLESGDKWF
        70         80         90        100        110        120
SLEFFPPRTA EGAVNLISRF DRMAAGGPLY IDVTWHPAGD PGSDKETSSM MIASTAVNYC
       130        140        150        160        170        180
GLETILHMTC CRQRLEEITG HLHKAKQLGL KNIMALRGDP IGDQWEEEEG GFNYAVDLVK
       190        200        210        220        230        240
HIRSEFGDYF DICVAGYPKG HPEAGSFEAD LKHLKEKVSA GADFIITQLF FEADTFFRFV
       250        260        270        280        290        300
KACTDMGITC PIVPGIFPIQ GYHSLRQLVK LSKLEVPQEI KDVIEPIKDN DAAIRNYGIE
       310        320        330        340        350        360
LAVSLCQELL ASGLVPGLHF YTLNREMATT EVLKRLGMWT EDPRRPLPWA LSAHPKRREE
       370        380        390        400        410        420
DVRPIFWASR PKSYIYRTQE WDEFPNGRWG NSSSPAFGEL KDYYLFYLKS KSPKEELLKM
       430        440        450        460        470        480
WGEELTSEES VFEVFVLYLS GEPNRNGHKV TCLPWNDEPL AAETSLLKEE LLRVNRQGIL
       490        500        510        520        530        540
TINSQPNING KPSSDPIVGW GPSGGYVFQK AYLEFFTSRE TAEALLQVLK KYELRVNYHL
       550        560        570        580        590        600
VNVKGENITN APELQPNAVT WGIFPGREII QPTVVDPVSF MFWKDEAFAL WIERWGKLYE
       610        620        630        640        650
EESPSRTIIQ YIHDNYFLVN LVDNDFPLDN CLWQVVEDTL ELLNRPTQNA RETEAP

Isoforms

- Isoform 2 of Methylenetetrahydrofolate reductase

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

1 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P42898-1-unknown	MVNEAR...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P42898-1-unknown	MVNEAR...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt105247

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SSKDSS	29	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000408307
...SSKDSS	29	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000398908
...SSKDSS	29	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000400460
...SSKDSS	29	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000365669
...SSKDSS	29	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112752
...TGHLHK	143	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000405082
...TGHLHK	143	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112750
...ETEAP	656	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ETEAP	656	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77355

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)