P43146: Netrin receptor DCC

General Information

Protein names	- Netrin receptor DCC - Colorectal cancer suppressor - Immunoglobulin superfamily DCC subclass member 1 - Tumor suppressor protein DCC
Gene names	DCC
Organism	Homo sapiens
Protease Family
Protease ID	I43.001
Chromosome location
UniProt ID	P43146

5 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MENSLRCVWV PKLAFVLFGA SLFSAHLQVT GFQIKAFTAL RFLSEPSDAV TMRGGNVLLD
        70         80         90        100        110        120
CSAESDRGVP VIKWKKDGIH LALGMDERKQ QLSNGSLLIQ NILHSRHHKP DEGLYQCEAS
       130        140        150        160        170        180
LGDSGSIISR TAKVAVAGPL RFLSQTESVT AFMGDTVLLK CEVIGEPMPT IHWQKNQQDL
       190        200        210        220        230        240
TPIPGDSRVV VLPSGALQIS RLQPGDIGIY RCSARNPASS RTGNEAEVRI LSDPGLHRQL
       250        260        270        280        290        300
YFLQRPSNVV AIEGKDAVLE CCVSGYPPPS FTWLRGEEVI QLRSKKYSLL GGSNLLISNV
       310        320        330        340        350        360
TDDDSGMYTC VVTYKNENIS ASAELTVLVP PWFLNHPSNL YAYESMDIEF ECTVSGKPVP
       370        380        390        400        410        420
TVNWMKNGDV VIPSDYFQIV GGSNLRILGV VKSDEGFYQC VAENEAGNAQ TSAQLIVPKP
       430        440        450        460        470        480
AIPSSSVLPS APRDVVPVLV SSRFVRLSWR PPAEAKGNIQ TFTVFFSREG DNRERALNTT
       490        500        510        520        530        540
QPGSLQLTVG NLKPEAMYTF RVVAYNEWGP GESSQPIKVA TQPELQVPGP VENLQAVSTS
       550        560        570        580        590        600
PTSILITWEP PAYANGPVQG YRLFCTEVST GKEQNIEVDG LSYKLEGLKK FTEYSLRFLA
       610        620        630        640        650        660
YNRYGPGVST DDITVVTLSD VPSAPPQNVS LEVVNSRSIK VSWLPPPSGT QNGFITGYKI
       670        680        690        700        710        720
RHRKTTRRGE METLEPNNLW YLFTGLEKGS QYSFQVSAMT VNGTGPPSNW YTAETPENDL
       730        740        750        760        770        780
DESQVPDQPS SLHVRPQTNC IIMSWTPPLN PNIVVRGYII GYGVGSPYAE TVRVDSKQRY
       790        800        810        820        830        840
YSIERLESSS HYVISLKAFN NAGEGVPLYE SATTRSITDP TDPVDYYPLL DDFPTSVPDL
       850        860        870        880        890        900
STPMLPPVGV QAVALTHDAV RVSWADNSVP KNQKTSEVRL YTVRWRTSFS ASAKYKSEDT
       910        920        930        940        950        960
TSLSYTATGL KPNTMYEFSV MVTKNRRSST WSMTAHATTY EAAPTSAPKD LTVITREGKP
       970        980        990       1000       1010       1020
RAVIVSWQPP LEANGKITAY ILFYTLDKNI PIDDWIMETI SGDRLTHQIM DLNLDTMYYF
      1030       1040       1050       1060       1070       1080
RIQARNSKGV GPLSDPILFR TLKVEHPDKM ANDQGRHGDG GYWPVDTNLI DRSTLNEPPI
      1090       1100       1110       1120       1130       1140
GQMHPPHGSV TPQKNSNLLV IIVVTVGVIT VLVVVIVAVI CTRRSSAQQR KKRATHSAGK
      1150       1160       1170       1180       1190       1200
RKGSQKDLRP PDLWIHHEEM EMKNIEKPSG TDPAGRDSPI QSCQDLTPVS HSQSETQLGS
      1210       1220       1230       1240       1250       1260
KSTSHSGQDT EEAGSSMSTL ERSLAARRAP RAKLMIPMDA QSNNPAVVSA IPVPTLESAQ
      1270       1280       1290       1300       1310       1320
YPGILPSPTC GYPHPQFTLR PVPFPTLSVD RGFGAGRSQS VSEGPTTQQP PMLPPSQPEH
      1330       1340       1350       1360       1370       1380
SSSEEAPSRT IPTACVRPTH PLRSFANPLL PPPMSAIEPK VPYTPLLSQP GPTLPKTHVK
      1390       1400       1410       1420       1430       1440
TASLGLAGKA RSPLLPVSVP TAPEVSEESH KPTEDSANVY EQDDLSEQMA SLEGLMKQLN

AITGSAF

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P43146-26-unknown	HLQVTG...	26	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P43146-67-unknown	RGVPVI...	67	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463131
P43146-153-unknown	MGDTVL...	153	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000397322
P43146-346-unknown	MDIEFE...	346	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000464582
P43146-346-unknown	MDIEFE...	346	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463766
P43146-1291-unknown	RGFGAG...	1291	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1836

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RFVRLS	447	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463766
...TLSVDR	1290	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1836
...TGSAF	1447	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	1290	SVDR.\|.RGFG	inferred from experiment	unknown	MEROPS	Bredesen DE	Mehlen P et al.:The DCC gene product induces ap... (C14.003)	9796814,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)