P43322: Pro-neuregulin-1, membrane-bound isoform

General Information

Protein names	- Pro-neuregulin-1, membrane-bound isoform - Pro-NRG1 - Neuregulin-1 - Acetylcholine receptor-inducing activity - ARIA - Glial growth factor - Heregulin - HRG - Neu differentiation factor - Sensory and motor neuron-derived factor
Gene names	Nrg1
Organism	Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID	P43322

2 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Alpha2A of Pro-neuregulin-1, membrane-bound isoform - Isoform Alpha2B of Pro-neuregulin-1, membrane-bound isoform - Isoform Alpha2C of Pro-neuregulin-1, membrane-bound isoform - Isoform Beta1 of Pro-neuregulin-1, membrane-bound isoform - Isoform Beta2 of Pro-neuregulin-1, membrane-bound isoform - Isoform BetA2A of Pro-neuregulin-1, membrane-bound isoform - Isoform Beta3 of Pro-neuregulin-1, membrane-bound isoform

Sequence View

        10         20         30         40         50         60
MSERKEGRGK GKGKKKDRGS RGKPGPAEGD PSPALPPRLK EMKSQESAAG SKLVLRCETS
        70         80         90        100        110        120
SEYSSLRFKW FKNGNELNRK NKPENIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN
       130        140        150        160        170        180
DSASANITIV ESNEFITGMP ASTETAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLI
       190        200        210        220        230        240
KCAEKEKTFC VNGGECFTVK DLSNPSRYLC KCPNEFTGDR CQNYVMASFY MTSRRKRQET
       250        260        270        280        290        300
EKPLERKLDH SLVKESKAEE LYQKRVLTIT GICIALLVVG IMCVVAYCKT KKQRQKLHDR
       310        320        330        340        350        360
LRQSLRSERS NLVNIANGPH HPNPPPENVQ LVNQYVSKNV ISSEHIVERE VETSFSTSHY
       370        380        390        400        410        420
TSTAHHSTTV TQTPSHSWSN GHTESVISES NSVIMMSSVE NSRHSSPAGG PRGRLHGLGG
       430        440        450        460        470        480
PRDNSFLRHA RETPDSYRDS PHSERYVSAM TTPARMSPVD FHTPSSPKSP PSEMSPPVSS
       490        500        510        520        530        540
MTVSMPSVAV SPFVEEERPL LLVTPPRLRE KKYDHHPQQL NSFHHNPAHQ STSLPPSPLR
       550        560        570        580        590        600
IVEDEEYETT QEYESVQEPV KKVTNSRRAK RTKPNGHIAN RLEMDSNTSS VSSNSESETE
       610        620        630        640        650        660
DERVGEDTPF LGIQNPLAAS LEVAPAFRLA ESRTNPAGRF STQEELQARL SSVIANQDPI

AV         10         20         30         40         50         60
MSERKEGRGK GKGKKKDRGS RGKPGPAEGD PSPALPPRLK EMKSQESAAG SKLVLRCETS
        70         80         90        100        110        120
SEYSSLRFKW FKNGNELNRK NKPENIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN
       130        140        150        160        170        180
DSASANITIV ESNEFITGMP ASTETAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLI
       190        200        210        220        230        240
KCAEKEKTFC VNGGECFTVK DLSNPSRYLC KCPNEFTGDR CQNYVMASFY MTSRRKRQET
       250        260        270        280        290        300
EKPLERKLDH SLVKESKAEE LYQKRVLTIT GICIALLVVG IMCVVAYCKT KKQRQKLHDR
       310        320        330        340        350        360
LRQSLRSERS NLVNIANGPH HPNPPPENVQ LVNQYVSKNV ISSEHIVERE VETSFSTSHY
       370        380        390        400        410        420
TSTAHHSTTV TQTPSHSWSN GHTESVISES NSVIMMSSVE NSRHSSPAGG PRGRLHGLGG
       430        440        450        460        470        480
PRDNSFLRHA RETPDSYRDS PHSERYVSAM TTPARMSPVD FHTPSSPKSP PSEMSPPVSS
       490        500        510        520        530        540
MTVSMPSVAV SPFVEEERPL LLVTPPRLRE KKYDHHPQQL NSFHHNPAHQ STSLPPSPLR
       550        560        570        580        590        600
IVEDEEYETT QEYESVQEPV KKVTNSRRAK RTKPNGHIAN RLEMDSNTSS VSSNSESETE
       610        620        630        640        650        660
DERVGEDTPF LGIQNPLAAS LEVAPAFRLA ESRTNPAGRF STQEELQARL SSVIANQDPI

AV         10         20         30         40         50         60
MSERKEGRGK GKGKKKDRGS RGKPGPAEGD PSPALPPRLK EMKSQESAAG SKLVLRCETS
        70         80         90        100        110        120
SEYSSLRFKW FKNGNELNRK NKPENIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN
       130        140        150        160        170        180
DSASANITIV ESNEFITGMP ASTETAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLI
       190        200        210        220        230        240
KCAEKEKTFC VNGGECFTVK DLSNPSRYLC KCPNEFTGDR CQNYVMASFY MTSRRKRQET
       250        260        270        280        290        300
EKPLERKLDH SLVKESKAEE LYQKRVLTIT GICIALLVVG IMCVVAYCKT KKQRQKLHDR
       310        320        330        340        350        360
LRQSLRSERS NLVNIANGPH HPNPPPENVQ LVNQYVSKNV ISSEHIVERE VETSFSTSHY
       370        380        390        400        410        420
TSTAHHSTTV TQTPSHSWSN GHTESVISES NSVIMMSSVE NSRHSSPAGG PRGRLHGLGG
       430        440        450        460        470        480
PRDNSFLRHA RETPDSYRDS PHSERYVSAM TTPARMSPVD FHTPSSPKSP PSEMSPPVSS
       490        500        510        520        530        540
MTVSMPSVAV SPFVEEERPL LLVTPPRLRE KKYDHHPQQL NSFHHNPAHQ STSLPPSPLR
       550        560        570        580        590        600
IVEDEEYETT QEYESVQEPV KKVTNSRRAK RTKPNGHIAN RLEMDSNTSS VSSNSESETE
       610        620        630        640        650        660
DERVGEDTPF LGIQNPLAAS LEVAPAFRLA ESRTNPAGRF STQEELQARL SSVIANQDPI

AV         10         20         30         40         50         60
MSERKEGRGK GKGKKKDRGS RGKPGPAEGD PSPALPPRLK EMKSQESAAG SKLVLRCETS
        70         80         90        100        110        120
SEYSSLRFKW FKNGNELNRK NKPENIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN
       130        140        150        160        170        180
DSASANITIV ESNEFITGMP ASTETAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLI
       190        200        210        220        230        240
KCAEKEKTFC VNGGECFTVK DLSNPSRYLC KCPNEFTGDR CQNYVMASFY MTSRRKRQET
       250        260        270        280        290        300
EKPLERKLDH SLVKESKAEE LYQKRVLTIT GICIALLVVG IMCVVAYCKT KKQRQKLHDR
       310        320        330        340        350        360
LRQSLRSERS NLVNIANGPH HPNPPPENVQ LVNQYVSKNV ISSEHIVERE VETSFSTSHY
       370        380        390        400        410        420
TSTAHHSTTV TQTPSHSWSN GHTESVISES NSVIMMSSVE NSRHSSPAGG PRGRLHGLGG
       430        440        450        460        470        480
PRDNSFLRHA RETPDSYRDS PHSERYVSAM TTPARMSPVD FHTPSSPKSP PSEMSPPVSS
       490        500        510        520        530        540
MTVSMPSVAV SPFVEEERPL LLVTPPRLRE KKYDHHPQQL NSFHHNPAHQ STSLPPSPLR
       550        560        570        580        590        600
IVEDEEYETT QEYESVQEPV KKVTNSRRAK RTKPNGHIAN RLEMDSNTSS VSSNSESETE
       610        620        630        640        650        660
DERVGEDTPF LGIQNPLAAS LEVAPAFRLA ESRTNPAGRF STQEELQARL SSVIANQDPI

AV         10         20         30         40         50         60
MSERKEGRGK GKGKKKDRGS RGKPGPAEGD PSPALPPRLK EMKSQESAAG SKLVLRCETS
        70         80         90        100        110        120
SEYSSLRFKW FKNGNELNRK NKPENIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN
       130        140        150        160        170        180
DSASANITIV ESNEFITGMP ASTETAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLI
       190        200        210        220        230        240
KCAEKEKTFC VNGGECFTVK DLSNPSRYLC KCPNEFTGDR CQNYVMASFY MTSRRKRQET
       250        260        270        280        290        300
EKPLERKLDH SLVKESKAEE LYQKRVLTIT GICIALLVVG IMCVVAYCKT KKQRQKLHDR
       310        320        330        340        350        360
LRQSLRSERS NLVNIANGPH HPNPPPENVQ LVNQYVSKNV ISSEHIVERE VETSFSTSHY
       370        380        390        400        410        420
TSTAHHSTTV TQTPSHSWSN GHTESVISES NSVIMMSSVE NSRHSSPAGG PRGRLHGLGG
       430        440        450        460        470        480
PRDNSFLRHA RETPDSYRDS PHSERYVSAM TTPARMSPVD FHTPSSPKSP PSEMSPPVSS
       490        500        510        520        530        540
MTVSMPSVAV SPFVEEERPL LLVTPPRLRE KKYDHHPQQL NSFHHNPAHQ STSLPPSPLR
       550        560        570        580        590        600
IVEDEEYETT QEYESVQEPV KKVTNSRRAK RTKPNGHIAN RLEMDSNTSS VSSNSESETE
       610        620        630        640        650        660
DERVGEDTPF LGIQNPLAAS LEVAPAFRLA ESRTNPAGRF STQEELQARL SSVIANQDPI

AV         10         20         30         40         50         60
MSERKEGRGK GKGKKKDRGS RGKPGPAEGD PSPALPPRLK EMKSQESAAG SKLVLRCETS
        70         80         90        100        110        120
SEYSSLRFKW FKNGNELNRK NKPENIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN
       130        140        150        160        170        180
DSASANITIV ESNEFITGMP ASTETAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLI
       190        200        210        220        230        240
KCAEKEKTFC VNGGECFTVK DLSNPSRYLC KCPNEFTGDR CQNYVMASFY MTSRRKRQET
       250        260        270        280        290        300
EKPLERKLDH SLVKESKAEE LYQKRVLTIT GICIALLVVG IMCVVAYCKT KKQRQKLHDR
       310        320        330        340        350        360
LRQSLRSERS NLVNIANGPH HPNPPPENVQ LVNQYVSKNV ISSEHIVERE VETSFSTSHY
       370        380        390        400        410        420
TSTAHHSTTV TQTPSHSWSN GHTESVISES NSVIMMSSVE NSRHSSPAGG PRGRLHGLGG
       430        440        450        460        470        480
PRDNSFLRHA RETPDSYRDS PHSERYVSAM TTPARMSPVD FHTPSSPKSP PSEMSPPVSS
       490        500        510        520        530        540
MTVSMPSVAV SPFVEEERPL LLVTPPRLRE KKYDHHPQQL NSFHHNPAHQ STSLPPSPLR
       550        560        570        580        590        600
IVEDEEYETT QEYESVQEPV KKVTNSRRAK RTKPNGHIAN RLEMDSNTSS VSSNSESETE
       610        620        630        640        650        660
DERVGEDTPF LGIQNPLAAS LEVAPAFRLA ESRTNPAGRF STQEELQARL SSVIANQDPI

AV         10         20         30         40         50         60
MSERKEGRGK GKGKKKDRGS RGKPGPAEGD PSPALPPRLK EMKSQESAAG SKLVLRCETS
        70         80         90        100        110        120
SEYSSLRFKW FKNGNELNRK NKPENIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN
       130        140        150        160        170        180
DSASANITIV ESNEFITGMP ASTETAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLI
       190        200        210        220        230        240
KCAEKEKTFC VNGGECFTVK DLSNPSRYLC KCPNEFTGDR CQNYVMASFY MTSRRKRQET
       250        260        270        280        290        300
EKPLERKLDH SLVKESKAEE LYQKRVLTIT GICIALLVVG IMCVVAYCKT KKQRQKLHDR
       310        320        330        340        350        360
LRQSLRSERS NLVNIANGPH HPNPPPENVQ LVNQYVSKNV ISSEHIVERE VETSFSTSHY
       370        380        390        400        410        420
TSTAHHSTTV TQTPSHSWSN GHTESVISES NSVIMMSSVE NSRHSSPAGG PRGRLHGLGG
       430        440        450        460        470        480
PRDNSFLRHA RETPDSYRDS PHSERYVSAM TTPARMSPVD FHTPSSPKSP PSEMSPPVSS
       490        500        510        520        530        540
MTVSMPSVAV SPFVEEERPL LLVTPPRLRE KKYDHHPQQL NSFHHNPAHQ STSLPPSPLR
       550        560        570        580        590        600
IVEDEEYETT QEYESVQEPV KKVTNSRRAK RTKPNGHIAN RLEMDSNTSS VSSNSESETE
       610        620        630        640        650        660
DERVGEDTPF LGIQNPLAAS LEVAPAFRLA ESRTNPAGRF STQEELQARL SSVIANQDPI

AV

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P43322-1-unknown	MSERKE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt193104
P43322-1-unknown	MSERKE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt193105
P43322-1-unknown	MSERKE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt193106
P43322-1-unknown	MSERKE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt193107
P43322-1-unknown	MSERKE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt193108
P43322-1-unknown	MSERKE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt193109
P43322-1-unknown	MSERKE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt193110
P43322-14-unknown	KKKDRG...	14	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P43322-14-unknown	KKKDRG...	14	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt194997
P43322-14-unknown	KKKDRG...	14	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt194998
P43322-14-unknown	KKKDRG...	14	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt194999
P43322-14-unknown	KKKDRG...	14	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195000
P43322-14-unknown	KKKDRG...	14	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195001
P43322-14-unknown	KKKDRG...	14	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195002
P43322-14-unknown	KKKDRG...	14	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195003

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ELYQKR	264	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DPIAV	662	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DPIAV	662	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153054
...DPIAV	662	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153055
...DPIAV	662	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153050
...DPIAV	662	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153053

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)