TopFIND 4.0

P43405: Tyrosine-protein kinase SYK

General Information

Protein names
- Tyrosine-protein kinase SYK
- 2.7.10.2
- Spleen tyrosine kinase
- p72-Syk
Gene names SYK
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P43405

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MASSGMADSA NHLPFFFGNI TREEAEDYLV QGGMSDGLYL LRQSRNYLGG FALSVAHGRK 
        70         80         90        100        110        120 
AHHYTIEREL NGTYAIAGGR THASPADLCH YHSQESDGLV CLLKKPFNRP QGVQPKTGPF 
       130        140        150        160        170        180 
EDLKENLIRE YVKQTWNLQG QALEQAIISQ KPQLEKLIAT TAHEKMPWFH GKISREESEQ 
       190        200        210        220        230        240 
IVLIGSKTNG KFLIRARDNN GSYALCLLHE GKVLHYRIDK DKTGKLSIPE GKKFDTLWQL 
       250        260        270        280        290        300 
VEHYSYKADG LLRVLTVPCQ KIGTQGNVNF GGRPQLPGSH PATWSAGGII SRIKSYSFPK 
       310        320        330        340        350        360 
PGHRKSSPAQ GNRQESTVSF NPYEPELAPW AADKGPQREA LPMDTEVYES PYADPEEIRP 
       370        380        390        400        410        420 
KEVYLDRKLL TLEDKELGSG NFGTVKKGYY QMKKVVKTVA VKILKNEAND PALKDELLAE 
       430        440        450        460        470        480 
ANVMQQLDNP YIVRMIGICE AESWMLVMEM AELGPLNKYL QQNRHVKDKN IIELVHQVSM 
       490        500        510        520        530        540 
GMKYLEESNF VHRDLAARNV LLVTQHYAKI SDFGLSKALR ADENYYKAQT HGKWPVKWYA 
       550        560        570        580        590        600 
PECINYYKFS SKSDVWSFGV LMWEAFSYGQ KPYRGMKGSE VTAMLEKGER MGCPAGCPRE 
       610        620        630    
MYDLMNLCWT YDVENRPGFA AVELRLRNYY YDVVN

Isoforms

- Isoform Short of Tyrosine-protein kinase SYK

Sequence View

        10         20         30         40         50         60 
MASSGMADSA NHLPFFFGNI TREEAEDYLV QGGMSDGLYL LRQSRNYLGG FALSVAHGRK 
        70         80         90        100        110        120 
AHHYTIEREL NGTYAIAGGR THASPADLCH YHSQESDGLV CLLKKPFNRP QGVQPKTGPF 
       130        140        150        160        170        180 
EDLKENLIRE YVKQTWNLQG QALEQAIISQ KPQLEKLIAT TAHEKMPWFH GKISREESEQ 
       190        200        210        220        230        240 
IVLIGSKTNG KFLIRARDNN GSYALCLLHE GKVLHYRIDK DKTGKLSIPE GKKFDTLWQL 
       250        260        270        280        290        300 
VEHYSYKADG LLRVLTVPCQ KIGTQGNVNF GGRPQLPGSH PATWSAGGII SRIKSYSFPK 
       310        320        330        340        350        360 
PGHRKSSPAQ GNRQESTVSF NPYEPELAPW AADKGPQREA LPMDTEVYES PYADPEEIRP 
       370        380        390        400        410        420 
KEVYLDRKLL TLEDKELGSG NFGTVKKGYY QMKKVVKTVA VKILKNEAND PALKDELLAE 
       430        440        450        460        470        480 
ANVMQQLDNP YIVRMIGICE AESWMLVMEM AELGPLNKYL QQNRHVKDKN IIELVHQVSM 
       490        500        510        520        530        540 
GMKYLEESNF VHRDLAARNV LLVTQHYAKI SDFGLSKALR ADENYYKAQT HGKWPVKWYA 
       550        560        570        580        590        600 
PECINYYKFS SKSDVWSFGV LMWEAFSYGQ KPYRGMKGSE VTAMLEKGER MGCPAGCPRE 
       610        620        630    
MYDLMNLCWT YDVENRPGFA AVELRLRNYY YDVVN



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


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Lab:



Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P43405-1-unknown MASSGM... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P43405-1-unknown MASSGM... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt79273

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...YDVVN 635 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...YDVVN 635 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt74891

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)