P45379: Troponin T, cardiac muscle

General Information

Protein names	- Troponin T, cardiac muscle - TnTc - Cardiac muscle troponin T - cTnT
Gene names	TNNT2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P45379

4 N-termini

6 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Troponin T, cardiac muscle - Isoform 3 of Troponin T, cardiac muscle - Isoform 4 of Troponin T, cardiac muscle - Isoform 5 of Troponin T, cardiac muscle - Isoform 6 of Troponin T, cardiac muscle - Isoform 7 of Troponin T, cardiac muscle - Isoform 8 of Troponin T, cardiac muscle - Isoform 9 of Troponin T, cardiac muscle - Isoform 10 of Troponin T, cardiac muscle - Isoform 11 of Troponin T, cardiac muscle - Isoform 12 of Troponin T, cardiac muscle

Sequence View

        10         20         30         40         50         60
MSDIEEVVEE YEEEEQEEAA VEEEEDWRED EDEQEEAAEE DAEAEAETEE TRAEEDEEEE
        70         80         90        100        110        120
EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQALIEAHF
       130        140        150        160        170        180
ENRKKEEEEL VSLKDRIERR RAERAEQQRI RNEREKERQN RLAEERARRE EEENRRKAED
       190        200        210        220        230        240
EARKKKALSN MMHFGGYIQK QAQTERKSGK RQTEREKKKK ILAERRKVLA IDHLNEDQLR
       250        260        270        280        290
EKAKELWQSI YNLEAEKFDL QEKFKQQKYE INVLRNRIND NQKVSKTRGK AKVTGRWK         10         20         30         40         50         60
MSDIEEVVEE YEEEEQEEAA VEEEEDWRED EDEQEEAAEE DAEAEAETEE TRAEEDEEEE
        70         80         90        100        110        120
EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQALIEAHF
       130        140        150        160        170        180
ENRKKEEEEL VSLKDRIERR RAERAEQQRI RNEREKERQN RLAEERARRE EEENRRKAED
       190        200        210        220        230        240
EARKKKALSN MMHFGGYIQK QAQTERKSGK RQTEREKKKK ILAERRKVLA IDHLNEDQLR
       250        260        270        280        290
EKAKELWQSI YNLEAEKFDL QEKFKQQKYE INVLRNRIND NQKVSKTRGK AKVTGRWK         10         20         30         40         50         60
MSDIEEVVEE YEEEEQEEAA VEEEEDWRED EDEQEEAAEE DAEAEAETEE TRAEEDEEEE
        70         80         90        100        110        120
EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQALIEAHF
       130        140        150        160        170        180
ENRKKEEEEL VSLKDRIERR RAERAEQQRI RNEREKERQN RLAEERARRE EEENRRKAED
       190        200        210        220        230        240
EARKKKALSN MMHFGGYIQK QAQTERKSGK RQTEREKKKK ILAERRKVLA IDHLNEDQLR
       250        260        270        280        290
EKAKELWQSI YNLEAEKFDL QEKFKQQKYE INVLRNRIND NQKVSKTRGK AKVTGRWK         10         20         30         40         50         60
MSDIEEVVEE YEEEEQEEAA VEEEEDWRED EDEQEEAAEE DAEAEAETEE TRAEEDEEEE
        70         80         90        100        110        120
EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQALIEAHF
       130        140        150        160        170        180
ENRKKEEEEL VSLKDRIERR RAERAEQQRI RNEREKERQN RLAEERARRE EEENRRKAED
       190        200        210        220        230        240
EARKKKALSN MMHFGGYIQK QAQTERKSGK RQTEREKKKK ILAERRKVLA IDHLNEDQLR
       250        260        270        280        290
EKAKELWQSI YNLEAEKFDL QEKFKQQKYE INVLRNRIND NQKVSKTRGK AKVTGRWK         10         20         30         40         50         60
MSDIEEVVEE YEEEEQEEAA VEEEEDWRED EDEQEEAAEE DAEAEAETEE TRAEEDEEEE
        70         80         90        100        110        120
EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQALIEAHF
       130        140        150        160        170        180
ENRKKEEEEL VSLKDRIERR RAERAEQQRI RNEREKERQN RLAEERARRE EEENRRKAED
       190        200        210        220        230        240
EARKKKALSN MMHFGGYIQK QAQTERKSGK RQTEREKKKK ILAERRKVLA IDHLNEDQLR
       250        260        270        280        290
EKAKELWQSI YNLEAEKFDL QEKFKQQKYE INVLRNRIND NQKVSKTRGK AKVTGRWK         10         20         30         40         50         60
MSDIEEVVEE YEEEEQEEAA VEEEEDWRED EDEQEEAAEE DAEAEAETEE TRAEEDEEEE
        70         80         90        100        110        120
EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQALIEAHF
       130        140        150        160        170        180
ENRKKEEEEL VSLKDRIERR RAERAEQQRI RNEREKERQN RLAEERARRE EEENRRKAED
       190        200        210        220        230        240
EARKKKALSN MMHFGGYIQK QAQTERKSGK RQTEREKKKK ILAERRKVLA IDHLNEDQLR
       250        260        270        280        290
EKAKELWQSI YNLEAEKFDL QEKFKQQKYE INVLRNRIND NQKVSKTRGK AKVTGRWK         10         20         30         40         50         60
MSDIEEVVEE YEEEEQEEAA VEEEEDWRED EDEQEEAAEE DAEAEAETEE TRAEEDEEEE
        70         80         90        100        110        120
EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQALIEAHF
       130        140        150        160        170        180
ENRKKEEEEL VSLKDRIERR RAERAEQQRI RNEREKERQN RLAEERARRE EEENRRKAED
       190        200        210        220        230        240
EARKKKALSN MMHFGGYIQK QAQTERKSGK RQTEREKKKK ILAERRKVLA IDHLNEDQLR
       250        260        270        280        290
EKAKELWQSI YNLEAEKFDL QEKFKQQKYE INVLRNRIND NQKVSKTRGK AKVTGRWK         10         20         30         40         50         60
MSDIEEVVEE YEEEEQEEAA VEEEEDWRED EDEQEEAAEE DAEAEAETEE TRAEEDEEEE
        70         80         90        100        110        120
EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQALIEAHF
       130        140        150        160        170        180
ENRKKEEEEL VSLKDRIERR RAERAEQQRI RNEREKERQN RLAEERARRE EEENRRKAED
       190        200        210        220        230        240
EARKKKALSN MMHFGGYIQK QAQTERKSGK RQTEREKKKK ILAERRKVLA IDHLNEDQLR
       250        260        270        280        290
EKAKELWQSI YNLEAEKFDL QEKFKQQKYE INVLRNRIND NQKVSKTRGK AKVTGRWK         10         20         30         40         50         60
MSDIEEVVEE YEEEEQEEAA VEEEEDWRED EDEQEEAAEE DAEAEAETEE TRAEEDEEEE
        70         80         90        100        110        120
EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQALIEAHF
       130        140        150        160        170        180
ENRKKEEEEL VSLKDRIERR RAERAEQQRI RNEREKERQN RLAEERARRE EEENRRKAED
       190        200        210        220        230        240
EARKKKALSN MMHFGGYIQK QAQTERKSGK RQTEREKKKK ILAERRKVLA IDHLNEDQLR
       250        260        270        280        290
EKAKELWQSI YNLEAEKFDL QEKFKQQKYE INVLRNRIND NQKVSKTRGK AKVTGRWK         10         20         30         40         50         60
MSDIEEVVEE YEEEEQEEAA VEEEEDWRED EDEQEEAAEE DAEAEAETEE TRAEEDEEEE
        70         80         90        100        110        120
EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQALIEAHF
       130        140        150        160        170        180
ENRKKEEEEL VSLKDRIERR RAERAEQQRI RNEREKERQN RLAEERARRE EEENRRKAED
       190        200        210        220        230        240
EARKKKALSN MMHFGGYIQK QAQTERKSGK RQTEREKKKK ILAERRKVLA IDHLNEDQLR
       250        260        270        280        290
EKAKELWQSI YNLEAEKFDL QEKFKQQKYE INVLRNRIND NQKVSKTRGK AKVTGRWK         10         20         30         40         50         60
MSDIEEVVEE YEEEEQEEAA VEEEEDWRED EDEQEEAAEE DAEAEAETEE TRAEEDEEEE
        70         80         90        100        110        120
EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQALIEAHF
       130        140        150        160        170        180
ENRKKEEEEL VSLKDRIERR RAERAEQQRI RNEREKERQN RLAEERARRE EEENRRKAED
       190        200        210        220        230        240
EARKKKALSN MMHFGGYIQK QAQTERKSGK RQTEREKKKK ILAERRKVLA IDHLNEDQLR
       250        260        270        280        290
EKAKELWQSI YNLEAEKFDL QEKFKQQKYE INVLRNRIND NQKVSKTRGK AKVTGRWK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 6 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P45379-2-unknown	MSDIEE...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P45379-2-unknown	MSDIEE...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P45379-1-unknown	MSDIEE...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92638
P45379-1-unknown	MSDIEE...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92639
P45379-1-unknown	MSDIEE...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92640
P45379-1-unknown	MSDIEE...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92641
P45379-1-unknown	MSDIEE...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92642
P45379-1-unknown	MSDIEE...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92645
P45379-2-Acetylation	SDIEEV...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P45379-2-Acetylation	SDIEEV...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111109
P45379-2-Acetylation	SDIEEV...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111110
P45379-2-Acetylation	SDIEEV...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111111
P45379-2-Acetylation	SDIEEV...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111112
P45379-2-Acetylation	SDIEEV...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111113
P45379-2-Acetylation	SDIEEV...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111114
P45379-2-Acetylation	SDIEEV...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P45379-99-unknown	DIHRKR...	99		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1838
P45379-99-unknown	DIHRKR...	99		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141508
P45379-99-unknown	DIHRKR...	99		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141753
P45379-99-unknown	DIHRKR...	99		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142067
P45379-99-unknown	DIHRKR...	99		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142241
P45379-99-unknown	DIHRKR...	99		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142276
P45379-99-unknown	DIHRKR...	99		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142277
P45379-99-unknown	DIHRKR...	99		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142336

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RVDFDD	98	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1838
...RVDFDD	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124685
...RVDFDD	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124936
...RVDFDD	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125250
...RVDFDD	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125429
...RVDFDD	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125466
...RVDFDD	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125467
...RVDFDD	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125527
...RVDFDD	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154154
...RMEKDL	108	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000408731
...RMEKDL	108	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154458
...RMEKDL	108	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154459
...RMEKDL	108	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154457
...RMEKDL	108	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154461
...RMEKDL	108	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154462
...RMEKDL	108	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154463
...RMEKDL	108	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154460
...LIEAHF	119	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000395163
...LIEAHF	119	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154570
...LIEAHF	119	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154571
...LIEAHF	119	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154569
...LIEAHF	119	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154573
...LIEAHF	119	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154574
...LIEAHF	119	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154575
...LIEAHF	119	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154572
...RKAEDE	180	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000402238
...RKAEDE	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155381
...RKAEDE	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155383
...RKAEDE	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155384
...RKAEDE	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155382
...RKAEDE	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155386
...RKAEDE	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155387
...RKAEDE	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155388
...RKAEDE	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155385
...KVSKTR	287	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000414036
...TGRWK	298	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TGRWK	298	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88263
...TGRWK	298	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88261
...TGRWK	298	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88260
...TGRWK	298	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88262
...TGRWK	298	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88258
...TGRWK	298	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88256
...TGRWK	298	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88257
...TGRWK	298	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88259

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	98	DFDD.\|.DIHR	inferred from experiment	unknown	MEROPS	Hajjar RJ	Communal C et al.:Functional consequences of casp... (C14.003)	11972044,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)