P45983: Mitogen-activated protein kinase 8

General Information

Protein names	- Mitogen-activated protein kinase 8 - MAP kinase 8 - MAPK 8 - 2.7.11.24 {ECO:0000269\|PubMed:10747973, ECO:0000269\|PubMed:10856240, ECO:0000269\|PubMed:11062067, ECO:0000269\|PubMed:16581800, ECO:0000269\|PubMed:17296730, ECO:0000269\|PubMed:17875713, ECO:0000269\|PubMed:8654373} - JNK-46 - Stress-activated protein kinase 1c - SAPK1c - Stress-activated protein kinase JNK1 - c-Jun N-terminal kinase 1
Gene names	MAPK8
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P45983

1 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 1 of Mitogen-activated protein kinase 8 - Isoform 3 of Mitogen-activated protein kinase 8 - Isoform 4 of Mitogen-activated protein kinase 8 - Isoform 5 of Mitogen-activated protein kinase 8

Sequence View

        10         20         30         40         50         60
MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP
        70         80         90        100        110        120
FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ
       130        140        150        160        170        180
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF
       190        200        210        220        230        240
MMTPYVVTRY YRAPEVILGM GYKENVDLWS VGCIMGEMVC HKILFPGRDY IDQWNKVIEQ
       250        260        270        280        290        300
LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK
       310        320        330        340        350        360
MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV
       370        380        390        400        410        420
MDLEERTKNG VIRGQPSPLG AAVINGSQHP SSSSSVNDVS SMSTDPTLAS DTDSSLEAAA

GPLGCCR         10         20         30         40         50         60
MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP
        70         80         90        100        110        120
FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ
       130        140        150        160        170        180
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF
       190        200        210        220        230        240
MMTPYVVTRY YRAPEVILGM GYKENVDLWS VGCIMGEMVC HKILFPGRDY IDQWNKVIEQ
       250        260        270        280        290        300
LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK
       310        320        330        340        350        360
MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV
       370        380        390        400        410        420
MDLEERTKNG VIRGQPSPLG AAVINGSQHP SSSSSVNDVS SMSTDPTLAS DTDSSLEAAA

GPLGCCR         10         20         30         40         50         60
MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP
        70         80         90        100        110        120
FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ
       130        140        150        160        170        180
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF
       190        200        210        220        230        240
MMTPYVVTRY YRAPEVILGM GYKENVDLWS VGCIMGEMVC HKILFPGRDY IDQWNKVIEQ
       250        260        270        280        290        300
LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK
       310        320        330        340        350        360
MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV
       370        380        390        400        410        420
MDLEERTKNG VIRGQPSPLG AAVINGSQHP SSSSSVNDVS SMSTDPTLAS DTDSSLEAAA

GPLGCCR         10         20         30         40         50         60
MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP
        70         80         90        100        110        120
FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ
       130        140        150        160        170        180
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF
       190        200        210        220        230        240
MMTPYVVTRY YRAPEVILGM GYKENVDLWS VGCIMGEMVC HKILFPGRDY IDQWNKVIEQ
       250        260        270        280        290        300
LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK
       310        320        330        340        350        360
MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV
       370        380        390        400        410        420
MDLEERTKNG VIRGQPSPLG AAVINGSQHP SSSSSVNDVS SMSTDPTLAS DTDSSLEAAA

GPLGCCR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

1 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P45983-1-unknown	MSRSKR...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P45983-1-unknown	MSRSKR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81200
P45983-1-unknown	MSRSKR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81201
P45983-1-unknown	MSRSKR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81202
P45983-1-unknown	MSRSKR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81203

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GIKHLH	142	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000387936
...GIKHLH	142	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000397729
...GIKHLH	142	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154892
...GIKHLH	142	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154893
...GIKHLH	142	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154894
...GIKHLH	142	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154895
...AGTSFM	180	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000393223
...AGTSFM	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155392
...AGTSFM	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155393
...AGTSFM	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155390
...AGTSFM	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155391
...LGCCR	427	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LGCCR	427	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76820

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)