P46681: D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2 {ECO:0000305}
| Protein names | - D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2 {ECO:0000305} - D-2HG--pyruvate transhydrogenase DLD2 {ECO:0000303|PubMed:26774271} - 1.1.99.40 {ECO:0000269|PubMed:26774271} - Actin-interacting protein 2 - D-lactate dehydrogenase cytochrome] 2, mitochondrial - 1.1.2.4 - D-lactate ferricytochrome C oxidoreductase - D-LCR |
|---|---|
| Gene names | DLD2 |
| Organism | Saccharomyces cerevisiae |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | P46681 |
3
N-termini
3
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MLRNILVRST GSNFKFAGRY MKSSALLGYY RRVNYYSTKI QTRLTSENYP DVHRDPRFKK
70 80 90 100 110 120
LTSDDLNYFK SILSEQEILR ASESEDLSFY NEDWMRKYKG QSKLVLRPKS VEKVSLILNY
130 140 150 160 170 180
CNDEKIAVVP QGGNTGLVGG SVPIFDELIL SLANLNKIRD FDPVSGILKC DAGVILENAN
190 200 210 220 230 240
NYVMEQNYMF PLDLGAKGSC HVGGVVATNA GGLRLLRYGS LHGSVLGLEV VMPNGQIVNS
250 260 270 280 290 300
MHSMRKDNTG YDLKQLFIGS EGTIGIITGV SILTVPKPKA FNVSYLSVES FEDVQKVFVR
310 320 330 340 350 360
ARQELSEILS AFEFMDAKSQ VLAKSQLKDA AFPLEDEHPF YILIETSGSN KDHDDSKLET
370 380 390 400 410 420
FLENVMEEGI VTDGVVAQDE TELQNLWKWR EMIPEASQAN GGVYKYDVSL PLKDLYSLVE
430 440 450 460 470 480
ATNARLSEAE LVGDSPKPVV GAIGYGHVGD GNLHLNVAVR EYNKNIEKTL EPFVYEFVSS
490 500 510 520 530
KHGSVSAEHG LGFQKKNYIG YSKSPEEVKM MKDLKVHYDP NGILNPYKYI
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
3 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| P46681-0-unknown | IMLRNI... | 0 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P46681-36-unknown | YSTKIQ... | 36 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32141 | |||
| P46681-36-unknown | YSTKIQ... | 36 | unknown | Voegtle FN. et al.: Global Analysis of the Mitochondrial N-Proteome... | 19837041 | ||||
| P46681-37-unknown | STKIQT... | 37 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32008 | |||
| P46681-37-unknown | STKIQT... | 37 | unknown | Voegtle FN. et al.: Global Analysis of the Mitochondrial N-Proteome... | 19837041 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...RRVNYY | 35 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32141 | |||
| ...RVNYYS | 36 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32008 | |||
| ...PYKYI | 530 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| MPPB_YEAST | 35 | VNYY.|.YSTK | inferred from experiment | unknown | MEROPS | Meisinger C | Vogtle FN et al.:Global analysis of the mitochon... (M24.026) | 19837041, |
| ICP55_YEAST | 36 | NYYS.|.STKI | inferred from experiment | unknown | MEROPS | Meisinger C | Vogtle FN et al.:Global analysis of the mitochon... (M24.026) | 19837041, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|