TopFIND 4.0

P46737: Lys-63-specific deubiquitinase BRCC36

General Information

Protein names
- Lys-63-specific deubiquitinase BRCC36
- 3.4.19.- {ECO:0000250|UniProtKB:P46736}
- BRCA1-A complex subunit BRCC36
- BRCA1/BRCA2-containing complex subunit 3
- BRCA1/BRCA2-containing complex subunit 36
- BRISC complex subunit BRCC36
Gene names Brcc3
Organism Mus musculus
Protease Family
Protease ID M67.004
Chromosome location
UniProt ID P46737

3

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAVQVVQAVQ AVHLESDAFL VCLNHALSTE KEEVMGLCIG ELNDDIRSDS KFTYTGTEMR 
        70         80         90        100        110        120 
TVQEKMDTIR IVHIHSVIIL RRSDKRKDRV EISPEQLSAA STEAERLAEL TGRPMRVVGW 
       130        140        150        160        170        180 
YHSHPHITVW PSHVDVRTQA MYQMMDQGFV GLIFSCFIED KNTKTGRVLY TCFQSIQAQK 
       190        200        210        220        230        240 
SSEYERIEIP IHIVPHITIG KVCLESAVEL PKILCQEEQD AYRRIHSLTH LDSVTKIHNG 
       250        260        270        280        290    
SVFTKNLCSQ MSAVSGPLLQ WLEDRLEQNQ QHLQELQQEK EELMEELSSL E

Isoforms

- Isoform 2 of Lys-63-specific deubiquitinase BRCC36

Sequence View

        10         20         30         40         50         60 
MAVQVVQAVQ AVHLESDAFL VCLNHALSTE KEEVMGLCIG ELNDDIRSDS KFTYTGTEMR 
        70         80         90        100        110        120 
TVQEKMDTIR IVHIHSVIIL RRSDKRKDRV EISPEQLSAA STEAERLAEL TGRPMRVVGW 
       130        140        150        160        170        180 
YHSHPHITVW PSHVDVRTQA MYQMMDQGFV GLIFSCFIED KNTKTGRVLY TCFQSIQAQK 
       190        200        210        220        230        240 
SSEYERIEIP IHIVPHITIG KVCLESAVEL PKILCQEEQD AYRRIHSLTH LDSVTKIHNG 
       250        260        270        280        290    
SVFTKNLCSQ MSAVSGPLLQ WLEDRLEQNQ QHLQELQQEK EELMEELSSL E



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Protease Assignment Confidence:


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Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LSSLE 291 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...LSSLE 291 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt64219

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)