P48023: Tumor necrosis factor ligand superfamily member 6

General Information

Protein names	- Tumor necrosis factor ligand superfamily member 6 - Apoptosis antigen ligand - APTL - CD95 ligand - CD95-L - Fas antigen ligand - Fas ligand - FasL - CD178 - Tumor necrosis factor ligand superfamily member 6, membrane form - Tumor necrosis factor ligand superfamily member 6, soluble form - Receptor-binding FasL ectodomain - Soluble Fas ligand - sFasL - ADAM10-processed FasL form - APL - FasL intracellular domain - FasL ICD - SPPL2A-processed FasL form - SPA
Gene names	FASLG
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P48023

5 N-termini

6 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQQPFNYPYP QIYWVDSSAS SPWAPPGTVL PCPTSVPRRP GQRRPPPPPP PPPLPPPPPP
        70         80         90        100        110        120
PPLPPLPLPP LKKRGNHSTG LCLLVMFFMV LVALVGLGLG MFQLFHLQKE LAELRESTSQ
       130        140        150        160        170        180
MHTASSLEKQ IGHPSPPPEK KELRKVAHLT GKSNSRSMPL EWEDTYGIVL LSGVKYKKGG
       190        200        210        220        230        240
LVINETGLYF VYSKVYFRGQ SCNNLPLSHK VYMRNSKYPQ DLVMMEGKMM SYCTTGQMWA
       250        260        270        280
RSSYLGAVFN LTSADHLYVN VSELSLVNFE ESQTFFGLYK L

Isoforms

- Isoform 2 of Tumor necrosis factor ligand superfamily member 6

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 6 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P48023-1-unknown	MQQPFN...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P48023-1-unknown	MQQPFN...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92602
P48023-111-unknown	LAELRE...	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24773
P48023-114-unknown	LRESTS...	114	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24774
P48023-127-unknown	LEKQIG...	127	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24775
P48023-130-unknown	QIGHPS...	130	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HSTGLC	81	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HSTGLC	81	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91437
...HLQKEL	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24773
...HLQKEL	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154477
...KELAEL	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24774
...KELAEL	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154517
...HTASSL	126	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24775
...SSLEKQ	129	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GLYKL	281	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP7_HUMAN	110	QKEL.\|.LAEL	inferred from experiment	unknown	MEROPS	Matrisian LM	Vargo-Gogola T et al.:Identification of novel matrix ... (M10.008)	12464266,
MMP7_HUMAN	113	LAEL.\|.LRES	inferred from experiment	unknown	MEROPS	Matrisian LM	Vargo-Gogola T et al.:Identification of novel matrix ... (M10.008)	12464266,
MMP7_HUMAN	126	ASSL.\|.LEKQ	inferred from experiment	unknown	MEROPS	Matrisian LM	Vargo-Gogola T et al.:Identification of novel matrix ... (M10.008)	12464266,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)