P48760: Folylpolyglutamate synthase, mitochondrial

General Information

Protein names	- Folylpolyglutamate synthase, mitochondrial - 6.3.2.17 - Folylpoly-gamma-glutamate synthetase - FPGS - Tetrahydrofolylpolyglutamate synthase - Tetrahydrofolate synthase
Gene names	Fpgs
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P48760

3 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Folylpolyglutamate synthase, mitochondrial - Isoform 3 of Folylpolyglutamate synthase, mitochondrial - Isoform 4 of Folylpolyglutamate synthase, mitochondrial - Isoform 5 of Folylpolyglutamate synthase, mitochondrial

Sequence View

        10         20         30         40         50         60
MSWARSRLCS TLSLAAVSAR GATTEGAARR GMSAWPAPQE PGMEYQDAVR TLNTLQTNAS
        70         80         90        100        110        120
YLEQVKRQRS DPQAQLEAME MYLARSGLQV EDLNRLNIIH VTGTKGKGST CAFTERILRN
       130        140        150        160        170        180
YGLKTGFFSS PHMVQVRERI RINGKPISPE LFTKHFWCLY NQLEEFKDDS HVSMPSYFRF
       190        200        210        220        230        240
LTLMAFHVFL QEKVDLAVVE VGIGGAFDCT NIIRKPVVCG VSSLGIDHTS LLGDTVEKIA
       250        260        270        280        290        300
WQKGGIFKPG VPAFTVVQPE GPLAVLRDRA QQIGCPLYLC PPLEALEEVG LPLSLGLEGA
       310        320        330        340        350        360
HQRSNAALAL QLAHCWLERQ DHQDIQELKV SRPSIRWQLP LAPVFRPTPH MRRGLRDTVW
       370        380        390        400        410        420
PGRTQILQRG PLTWYLDGAH TTSSVQACVH WYRQSLERSK RTDGGSEVHI LLFNSTGDRD
       430        440        450        460        470        480
SAALLKLLQP CQFDYAVFCP NVTEVSSIGN ADQQNFTVTL DQVLLRCLQH QQHWNGLAEK
       490        500        510        520        530        540
QASSNLWSSC GPDPAGPGSL LLAPHPPQPT RTSSLVFSCI SHALLWISQG RDPIFQPQSL
       550        560        570        580
PRNLLNHPTA NSGASILREA AAIHVLVTGS LHLVGGVLKL LDPSMSQ         10         20         30         40         50         60
MSWARSRLCS TLSLAAVSAR GATTEGAARR GMSAWPAPQE PGMEYQDAVR TLNTLQTNAS
        70         80         90        100        110        120
YLEQVKRQRS DPQAQLEAME MYLARSGLQV EDLNRLNIIH VTGTKGKGST CAFTERILRN
       130        140        150        160        170        180
YGLKTGFFSS PHMVQVRERI RINGKPISPE LFTKHFWCLY NQLEEFKDDS HVSMPSYFRF
       190        200        210        220        230        240
LTLMAFHVFL QEKVDLAVVE VGIGGAFDCT NIIRKPVVCG VSSLGIDHTS LLGDTVEKIA
       250        260        270        280        290        300
WQKGGIFKPG VPAFTVVQPE GPLAVLRDRA QQIGCPLYLC PPLEALEEVG LPLSLGLEGA
       310        320        330        340        350        360
HQRSNAALAL QLAHCWLERQ DHQDIQELKV SRPSIRWQLP LAPVFRPTPH MRRGLRDTVW
       370        380        390        400        410        420
PGRTQILQRG PLTWYLDGAH TTSSVQACVH WYRQSLERSK RTDGGSEVHI LLFNSTGDRD
       430        440        450        460        470        480
SAALLKLLQP CQFDYAVFCP NVTEVSSIGN ADQQNFTVTL DQVLLRCLQH QQHWNGLAEK
       490        500        510        520        530        540
QASSNLWSSC GPDPAGPGSL LLAPHPPQPT RTSSLVFSCI SHALLWISQG RDPIFQPQSL
       550        560        570        580
PRNLLNHPTA NSGASILREA AAIHVLVTGS LHLVGGVLKL LDPSMSQ         10         20         30         40         50         60
MSWARSRLCS TLSLAAVSAR GATTEGAARR GMSAWPAPQE PGMEYQDAVR TLNTLQTNAS
        70         80         90        100        110        120
YLEQVKRQRS DPQAQLEAME MYLARSGLQV EDLNRLNIIH VTGTKGKGST CAFTERILRN
       130        140        150        160        170        180
YGLKTGFFSS PHMVQVRERI RINGKPISPE LFTKHFWCLY NQLEEFKDDS HVSMPSYFRF
       190        200        210        220        230        240
LTLMAFHVFL QEKVDLAVVE VGIGGAFDCT NIIRKPVVCG VSSLGIDHTS LLGDTVEKIA
       250        260        270        280        290        300
WQKGGIFKPG VPAFTVVQPE GPLAVLRDRA QQIGCPLYLC PPLEALEEVG LPLSLGLEGA
       310        320        330        340        350        360
HQRSNAALAL QLAHCWLERQ DHQDIQELKV SRPSIRWQLP LAPVFRPTPH MRRGLRDTVW
       370        380        390        400        410        420
PGRTQILQRG PLTWYLDGAH TTSSVQACVH WYRQSLERSK RTDGGSEVHI LLFNSTGDRD
       430        440        450        460        470        480
SAALLKLLQP CQFDYAVFCP NVTEVSSIGN ADQQNFTVTL DQVLLRCLQH QQHWNGLAEK
       490        500        510        520        530        540
QASSNLWSSC GPDPAGPGSL LLAPHPPQPT RTSSLVFSCI SHALLWISQG RDPIFQPQSL
       550        560        570        580
PRNLLNHPTA NSGASILREA AAIHVLVTGS LHLVGGVLKL LDPSMSQ         10         20         30         40         50         60
MSWARSRLCS TLSLAAVSAR GATTEGAARR GMSAWPAPQE PGMEYQDAVR TLNTLQTNAS
        70         80         90        100        110        120
YLEQVKRQRS DPQAQLEAME MYLARSGLQV EDLNRLNIIH VTGTKGKGST CAFTERILRN
       130        140        150        160        170        180
YGLKTGFFSS PHMVQVRERI RINGKPISPE LFTKHFWCLY NQLEEFKDDS HVSMPSYFRF
       190        200        210        220        230        240
LTLMAFHVFL QEKVDLAVVE VGIGGAFDCT NIIRKPVVCG VSSLGIDHTS LLGDTVEKIA
       250        260        270        280        290        300
WQKGGIFKPG VPAFTVVQPE GPLAVLRDRA QQIGCPLYLC PPLEALEEVG LPLSLGLEGA
       310        320        330        340        350        360
HQRSNAALAL QLAHCWLERQ DHQDIQELKV SRPSIRWQLP LAPVFRPTPH MRRGLRDTVW
       370        380        390        400        410        420
PGRTQILQRG PLTWYLDGAH TTSSVQACVH WYRQSLERSK RTDGGSEVHI LLFNSTGDRD
       430        440        450        460        470        480
SAALLKLLQP CQFDYAVFCP NVTEVSSIGN ADQQNFTVTL DQVLLRCLQH QQHWNGLAEK
       490        500        510        520        530        540
QASSNLWSSC GPDPAGPGSL LLAPHPPQPT RTSSLVFSCI SHALLWISQG RDPIFQPQSL
       550        560        570        580
PRNLLNHPTA NSGASILREA AAIHVLVTGS LHLVGGVLKL LDPSMSQ

Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P48760-14-unknown	LAAVSA...	14		inferred from electronic annotation	unknown	TISdb	inferred from TISdb
P48760-43-Acetylation	MEYQDA...	43	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P48760-43-Acetylation	MEYQDA...	43	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115499
P48760-43-Acetylation	MEYQDA...	43	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115498
P48760-43-unknown	MEYQDA...	43		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75360
P48760-43-unknown	MEYQDA...	43		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101328

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PSMSQ	587	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PSMSQ	587	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70978
...PSMSQ	587	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70981
...PSMSQ	587	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70980
...PSMSQ	587	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70979

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

TopFIND

P48760: Folylpolyglutamate synthase, mitochondrial

General Information

3

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates