P48775: Tryptophan 2,3-dioxygenase {ECO:0000255|HAMAP-Rule:MF_03020}

General Information

Protein names	- Tryptophan 2,3-dioxygenase {ECO:0000255\|HAMAP-Rule:MF_03020} - TDO {ECO:0000255\|HAMAP-Rule:MF_03020} - 1.13.11.11 {ECO:0000255\|HAMAP-Rule:MF_03020, ECO:0000269\|PubMed:25066423, ECO:0000269\|PubMed:27762317, ECO:0000269\|PubMed:28285122} - Tryptamin 2,3-dioxygenase {ECO:0000255\|HAMAP-Rule:MF_03020} - Tryptophan oxygenase {ECO:0000255\|HAMAP-Rule:MF_03020} - TO {ECO:0000255\|HAMAP-Rule:MF_03020} - TRPO {ECO:0000255\|HAMAP-Rule:MF_03020} - Tryptophan pyrrolase {ECO:0000255\|HAMAP-Rule:MF_03020} - Tryptophanase {ECO:0000255\|HAMAP-Rule:MF_03020}
Gene names	TDO2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P48775

2 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSGCPFLGNN FGYTFKKLPV EGSEEDKSQT GVNRASKGGL IYGNYLHLEK VLNAQELQSE
        70         80         90        100        110        120
TKGNKIHDEH LFIITHQAYE LWFKQILWEL DSVREIFQNG HVRDERNMLK VVSRMHRVSV
       130        140        150        160        170        180
ILKLLVQQFS ILETMTALDF NDFREYLSPA SGFQSLQFRL LENKIGVLQN MRVPYNRRHY
       190        200        210        220        230        240
RDNFKGEENE LLLKSEQEKT LLELVEAWLE RTPGLEPHGF NFWGKLEKNI TRGLEEEFIR
       250        260        270        280        290        300
IQAKEESEEK EEQVAEFQKQ KEVLLSLFDE KRHEHLLSKG ERRLSYRALQ GALMIYFYRE
       310        320        330        340        350        360
EPRFQVPFQL LTSLMDIDSL MTKWRYNHVC MVHRMLGSKA GTGGSSGYHY LRSTVSDRYK
       370        380        390        400
VFVDLFNLST YLIPRHWIPK MNPTIHKFLY TAEYCDSSYF SSDESD

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P48775-1-unknown	MSGCPF...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P48775-108-unknown	MLKVVS...	108	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000423394
P48775-108-unknown	MLKVVS...	108	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000424384
P48775-108-unknown	MLKVVS...	108	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000461534
P48775-108-unknown	MLKVVS...	108	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000461272

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GFQSLQ	156	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000424384
...GFQSLQ	156	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000461272
...LQNMRV	172	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000423394
...LQNMRV	172	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000461534
...SDESD	406	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)