TopFIND 4.0

P49354: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

General Information

Protein names
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
- 2.5.1.58 {ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8419339, ECO:0000269|PubMed:8494894}
- 2.5.1.59 {ECO:0000269|PubMed:16893176}
- CAAX farnesyltransferase subunit alpha
- FTase-alpha
- Ras proteins prenyltransferase subunit alpha
- Type I protein geranyl-geranyltransferase subunit alpha
- GGTase-I-alpha
Gene names FNTA
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P49354

4

N-termini

2

C-termini

1

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAATEGVGEA AQGGEPGQPA QPPPQPHPPP PQQQHKEEMA AEAGEAVASP MDDGFVSLDS 
        70         80         90        100        110        120 
PSYVLYRDRA EWADIDPVPQ NDGPNPVVQI IYSDKFRDVY DYFRAVLQRD ERSERAFKLT 
       130        140        150        160        170        180 
RDAIELNAAN YTVWHFRRVL LKSLQKDLHE EMNYITAIIE EQPKNYQVWH HRRVLVEWLR 
       190        200        210        220        230        240 
DPSQELEFIA DILNQDAKNY HAWQHRQWVI QEFKLWDNEL QYVDQLLKED VRNNSVWNQR 
       250        260        270        280        290        300 
YFVISNTTGY NDRAVLEREV QYTLEMIKLV PHNESAWNYL KGILQDRGLS KYPNLLNQLL 
       310        320        330        340        350        360 
DLQPSHSSPY LIAFLVDIYE DMLENQCDNK EDILNKALEL CEILAKEKDT IRKEYWRYIG 
       370    
RSLQSKHSTE NDSPTNVQQ

Isoforms

- Isoform 2 of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

Sequence View

        10         20         30         40         50         60 
MAATEGVGEA AQGGEPGQPA QPPPQPHPPP PQQQHKEEMA AEAGEAVASP MDDGFVSLDS 
        70         80         90        100        110        120 
PSYVLYRDRA EWADIDPVPQ NDGPNPVVQI IYSDKFRDVY DYFRAVLQRD ERSERAFKLT 
       130        140        150        160        170        180 
RDAIELNAAN YTVWHFRRVL LKSLQKDLHE EMNYITAIIE EQPKNYQVWH HRRVLVEWLR 
       190        200        210        220        230        240 
DPSQELEFIA DILNQDAKNY HAWQHRQWVI QEFKLWDNEL QYVDQLLKED VRNNSVWNQR 
       250        260        270        280        290        300 
YFVISNTTGY NDRAVLEREV QYTLEMIKLV PHNESAWNYL KGILQDRGLS KYPNLLNQLL 
       310        320        330        340        350        360 
DLQPSHSSPY LIAFLVDIYE DMLENQCDNK EDILNKALEL CEILAKEKDT IRKEYWRYIG 
       370    
RSLQSKHSTE NDSPTNVQQ



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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)