P49641: Alpha-mannosidase 2x

General Information

Protein names	- Alpha-mannosidase 2x - 3.2.1.114 {ECO:0000250\|UniProtKB:P28494} - Alpha-mannosidase IIx - Man IIx - Mannosidase alpha class 2A member 2 - Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
Gene names	MAN2A2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49641

2 N-termini

11 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKLKKQVTVC GAAIFCVAVF SLYLMLDRVQ HDPTRHQNGG NFPRSQISVL QNRIEQLEQL
        70         80         90        100        110        120
LEENHEIISH IKDSVLELTA NAEGPPAMLP YYTVNGSWVV PPEPRPSFFS ISPQDCQFAL
       130        140        150        160        170        180
GGRGQKPELQ MLTVSEELPF DNVDGGVWRQ GFDISYDPHD WDAEDLQVFV VPHSHNDPGW
       190        200        210        220        230        240
IKTFDKYYTE QTQHILNSMV SKLQEDPRRR FLWAEVSFFA KWWDNINVQK RAAVRRLVGN
       250        260        270        280        290        300
GQLEIATGGW VMPDEANSHY FALIDQLIEG HQWLERNLGA TPRSGWAVDP FGYSSTMPYL
       310        320        330        340        350        360
LRRANLTSML IQRVHYAIKK HFAATHSLEF MWRQTWDSDS STDIFCHMMP FYSYDVPHTC
       370        380        390        400        410        420
GPDPKICCQF DFKRLPGGRI NCPWKVPPRA ITEANVAERA ALLLDQYRKK SQLFRSNVLL
       430        440        450        460        470        480
VPLGDDFRYD KPQEWDAQFF NYQRLFDFFN SRPNLHVQAQ FGTLSDYFDA LYKRTGVEPG
       490        500        510        520        530        540
ARPPGFPVLS GDFFSYADRE DHYWTGYYTS RPFYKSLDRV LEAHLRGAEV LYSLAAAHAR
       550        560        570        580        590        600
RSGLAGRYPL SDFTLLTEAR RTLGLFQHHD AITGTAKEAV VVDYGVRLLR SLVNLKQVII
       610        620        630        640        650        660
HAAHYLVLGD KETYHFDPEA PFLQVDDTRL SHDALPERTV IQLDSSPRFV VLFNPLEQER
       670        680        690        700        710        720
FSMVSLLVNS PRVRVLSEEG QPLAVQISAH WSSATEAVPD VYQVSVPVRL PALGLGVLQL
       730        740        750        760        770        780
QLGLDGHRTL PSSVRIYLHG RQLSVSRHEA FPLRVIDSGT SDFALSNRYM QVWFSGLTGL
       790        800        810        820        830        840
LKSIRRVDEE HEQQVDMQVL VYGTRTSKDK SGAYLFLPDG EAKPYVPKEP PVLRVTEGPF
       850        860        870        880        890        900
FSEVVAYYEH IHQAVRLYNL PGVEGLSLDI SSLVDIRDYV NKELALHIHT DIDSQGIFFT
       910        920        930        940        950        960
DLNGFQVQPR RYLKKLPLQA NFYPMPVMAY IQDAQKRLTL HTAQALGVSS LKDGQLEVIL
       970        980        990       1000       1010       1020
DRRLMQDDNR GLGQGLKDNK RTCNRFRLLL ERRTVGSEVQ DSHSTSYPSL LSHLTSMYLN
      1030       1040       1050       1060       1070       1080
APALALPVAR MQLPGPGLRS FHPLASSLPC DFHLLNLRTL QAEEDTLPSA ETALILHRKG
      1090       1100       1110       1120       1130       1140
FDCGLEAKNL GFNCTTSQGK VALGSLFHGL DVVFLQPTSL TLLYPLASPS NSTDVYLEPM
      1150
EIATFRLRLG

Isoforms

- Isoform 1 of Alpha-mannosidase 2x - Isoform 2 of Alpha-mannosidase 2x

Sequence View

        10         20         30         40         50         60
MKLKKQVTVC GAAIFCVAVF SLYLMLDRVQ HDPTRHQNGG NFPRSQISVL QNRIEQLEQL
        70         80         90        100        110        120
LEENHEIISH IKDSVLELTA NAEGPPAMLP YYTVNGSWVV PPEPRPSFFS ISPQDCQFAL
       130        140        150        160        170        180
GGRGQKPELQ MLTVSEELPF DNVDGGVWRQ GFDISYDPHD WDAEDLQVFV VPHSHNDPGW
       190        200        210        220        230        240
IKTFDKYYTE QTQHILNSMV SKLQEDPRRR FLWAEVSFFA KWWDNINVQK RAAVRRLVGN
       250        260        270        280        290        300
GQLEIATGGW VMPDEANSHY FALIDQLIEG HQWLERNLGA TPRSGWAVDP FGYSSTMPYL
       310        320        330        340        350        360
LRRANLTSML IQRVHYAIKK HFAATHSLEF MWRQTWDSDS STDIFCHMMP FYSYDVPHTC
       370        380        390        400        410        420
GPDPKICCQF DFKRLPGGRI NCPWKVPPRA ITEANVAERA ALLLDQYRKK SQLFRSNVLL
       430        440        450        460        470        480
VPLGDDFRYD KPQEWDAQFF NYQRLFDFFN SRPNLHVQAQ FGTLSDYFDA LYKRTGVEPG
       490        500        510        520        530        540
ARPPGFPVLS GDFFSYADRE DHYWTGYYTS RPFYKSLDRV LEAHLRGAEV LYSLAAAHAR
       550        560        570        580        590        600
RSGLAGRYPL SDFTLLTEAR RTLGLFQHHD AITGTAKEAV VVDYGVRLLR SLVNLKQVII
       610        620        630        640        650        660
HAAHYLVLGD KETYHFDPEA PFLQVDDTRL SHDALPERTV IQLDSSPRFV VLFNPLEQER
       670        680        690        700        710        720
FSMVSLLVNS PRVRVLSEEG QPLAVQISAH WSSATEAVPD VYQVSVPVRL PALGLGVLQL
       730        740        750        760        770        780
QLGLDGHRTL PSSVRIYLHG RQLSVSRHEA FPLRVIDSGT SDFALSNRYM QVWFSGLTGL
       790        800        810        820        830        840
LKSIRRVDEE HEQQVDMQVL VYGTRTSKDK SGAYLFLPDG EAKPYVPKEP PVLRVTEGPF
       850        860        870        880        890        900
FSEVVAYYEH IHQAVRLYNL PGVEGLSLDI SSLVDIRDYV NKELALHIHT DIDSQGIFFT
       910        920        930        940        950        960
DLNGFQVQPR RYLKKLPLQA NFYPMPVMAY IQDAQKRLTL HTAQALGVSS LKDGQLEVIL
       970        980        990       1000       1010       1020
DRRLMQDDNR GLGQGLKDNK RTCNRFRLLL ERRTVGSEVQ DSHSTSYPSL LSHLTSMYLN
      1030       1040       1050       1060       1070       1080
APALALPVAR MQLPGPGLRS FHPLASSLPC DFHLLNLRTL QAEEDTLPSA ETALILHRKG
      1090       1100       1110       1120       1130       1140
FDCGLEAKNL GFNCTTSQGK VALGSLFHGL DVVFLQPTSL TLLYPLASPS NSTDVYLEPM
      1150
EIATFRLRLG         10         20         30         40         50         60
MKLKKQVTVC GAAIFCVAVF SLYLMLDRVQ HDPTRHQNGG NFPRSQISVL QNRIEQLEQL
        70         80         90        100        110        120
LEENHEIISH IKDSVLELTA NAEGPPAMLP YYTVNGSWVV PPEPRPSFFS ISPQDCQFAL
       130        140        150        160        170        180
GGRGQKPELQ MLTVSEELPF DNVDGGVWRQ GFDISYDPHD WDAEDLQVFV VPHSHNDPGW
       190        200        210        220        230        240
IKTFDKYYTE QTQHILNSMV SKLQEDPRRR FLWAEVSFFA KWWDNINVQK RAAVRRLVGN
       250        260        270        280        290        300
GQLEIATGGW VMPDEANSHY FALIDQLIEG HQWLERNLGA TPRSGWAVDP FGYSSTMPYL
       310        320        330        340        350        360
LRRANLTSML IQRVHYAIKK HFAATHSLEF MWRQTWDSDS STDIFCHMMP FYSYDVPHTC
       370        380        390        400        410        420
GPDPKICCQF DFKRLPGGRI NCPWKVPPRA ITEANVAERA ALLLDQYRKK SQLFRSNVLL
       430        440        450        460        470        480
VPLGDDFRYD KPQEWDAQFF NYQRLFDFFN SRPNLHVQAQ FGTLSDYFDA LYKRTGVEPG
       490        500        510        520        530        540
ARPPGFPVLS GDFFSYADRE DHYWTGYYTS RPFYKSLDRV LEAHLRGAEV LYSLAAAHAR
       550        560        570        580        590        600
RSGLAGRYPL SDFTLLTEAR RTLGLFQHHD AITGTAKEAV VVDYGVRLLR SLVNLKQVII
       610        620        630        640        650        660
HAAHYLVLGD KETYHFDPEA PFLQVDDTRL SHDALPERTV IQLDSSPRFV VLFNPLEQER
       670        680        690        700        710        720
FSMVSLLVNS PRVRVLSEEG QPLAVQISAH WSSATEAVPD VYQVSVPVRL PALGLGVLQL
       730        740        750        760        770        780
QLGLDGHRTL PSSVRIYLHG RQLSVSRHEA FPLRVIDSGT SDFALSNRYM QVWFSGLTGL
       790        800        810        820        830        840
LKSIRRVDEE HEQQVDMQVL VYGTRTSKDK SGAYLFLPDG EAKPYVPKEP PVLRVTEGPF
       850        860        870        880        890        900
FSEVVAYYEH IHQAVRLYNL PGVEGLSLDI SSLVDIRDYV NKELALHIHT DIDSQGIFFT
       910        920        930        940        950        960
DLNGFQVQPR RYLKKLPLQA NFYPMPVMAY IQDAQKRLTL HTAQALGVSS LKDGQLEVIL
       970        980        990       1000       1010       1020
DRRLMQDDNR GLGQGLKDNK RTCNRFRLLL ERRTVGSEVQ DSHSTSYPSL LSHLTSMYLN
      1030       1040       1050       1060       1070       1080
APALALPVAR MQLPGPGLRS FHPLASSLPC DFHLLNLRTL QAEEDTLPSA ETALILHRKG
      1090       1100       1110       1120       1130       1140
FDCGLEAKNL GFNCTTSQGK VALGSLFHGL DVVFLQPTSL TLLYPLASPS NSTDVYLEPM
      1150
EIATFRLRLG

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P49641-1-unknown	MKLKKQ...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P49641-1-unknown	MKLKKQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80211
P49641-316-unknown	YAIKKH...	316	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000453140
P49641-316-unknown	YAIKKH...	316	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198947

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QISVLQ	50	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452691
...QISVLQ	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153891
...ISHIKD	72	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000453740
...ISHIKD	72	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154064
...KDSVLE	76	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000453956
...KDSVLE	76	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154091
...CQFALG	120	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000453078
...CQFALG	120	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154590
...VHYAIK	318	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452897
...SVRIYL	737	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452928
...VIDSGT	759	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452866
...EQQVDM	796	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75829
...VARMQL	1032	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000453253
...QPTSLT	1120	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000453341
...RLRLG	1150	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

TopFIND

P49641: Alpha-mannosidase 2x

General Information

2

N-termini

11

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

2 N-termini - 11 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates