P49757: Protein numb homolog

General Information

Protein names	- Protein numb homolog - h-Numb - Protein S171
Gene names	NUMB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49757

5 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Protein numb homolog - Isoform 3 of Protein numb homolog - Isoform 4 of Protein numb homolog - Isoform 5 of Protein numb homolog - Isoform 6 of Protein numb homolog - Isoform 7 of Protein numb homolog - Isoform 8 of Protein numb homolog - Isoform 9 of Protein numb homolog

Sequence View

        10         20         30         40         50         60
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD ESRGMHICED
        70         80         90        100        110        120
AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE KTKDLIVDQT IEKVSFCAPD
       130        140        150        160        170        180
RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT GERLSHAVGC AFAACLERKQ KREKECGVTA
       190        200        210        220        230        240
TFDASRTTFT REGSFRVTTA TEQAEREEIM KQMQDAKKAE TDKIVVGSSV APGNTAPSPS
       250        260        270        280        290        300
SPTSPTSDAT TSLEMNNPHA IPRRHAPIEQ LARQGSFRGF PALSQKMSPF KRQLSLRINE
       310        320        330        340        350        360
LPSTMQRKTD FPIKNAVPEV EGEAESISSL CSQITNAFST PEDPFSSAPM TKPVTVVAPQ
       370        380        390        400        410        420
SPTFQANGTD SAFHVLAKPA HTALAPVAMP VRETNPWAHA PDAANKEIAA TCSGTEWGQS
       430        440        450        460        470        480
SGAASPGLFQ AGHRRTPSEA DRWLEEVSKS VRAQQPQASA APLQPVLQPP PPTAISQPAS
       490        500        510        520        530        540
PFQGNAFLTS QPVPVGVVPA LQPAFVPAQS YPVANGMPYP APNVPVVGIT PSQMVANVFG
       550        560        570        580        590        600
TAGHPQAAHP HQSPSLVRQQ TFPHYEASSA TTSPFFKPPA QHLNGSAAFN GVDDGRLASA
       610        620        630        640        650
DRHTEVPTGT CPVDPFEAQW AALENKSKQR TNPSPTNPFS SDLQKTFEIE L         10         20         30         40         50         60
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD ESRGMHICED
        70         80         90        100        110        120
AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE KTKDLIVDQT IEKVSFCAPD
       130        140        150        160        170        180
RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT GERLSHAVGC AFAACLERKQ KREKECGVTA
       190        200        210        220        230        240
TFDASRTTFT REGSFRVTTA TEQAEREEIM KQMQDAKKAE TDKIVVGSSV APGNTAPSPS
       250        260        270        280        290        300
SPTSPTSDAT TSLEMNNPHA IPRRHAPIEQ LARQGSFRGF PALSQKMSPF KRQLSLRINE
       310        320        330        340        350        360
LPSTMQRKTD FPIKNAVPEV EGEAESISSL CSQITNAFST PEDPFSSAPM TKPVTVVAPQ
       370        380        390        400        410        420
SPTFQANGTD SAFHVLAKPA HTALAPVAMP VRETNPWAHA PDAANKEIAA TCSGTEWGQS
       430        440        450        460        470        480
SGAASPGLFQ AGHRRTPSEA DRWLEEVSKS VRAQQPQASA APLQPVLQPP PPTAISQPAS
       490        500        510        520        530        540
PFQGNAFLTS QPVPVGVVPA LQPAFVPAQS YPVANGMPYP APNVPVVGIT PSQMVANVFG
       550        560        570        580        590        600
TAGHPQAAHP HQSPSLVRQQ TFPHYEASSA TTSPFFKPPA QHLNGSAAFN GVDDGRLASA
       610        620        630        640        650
DRHTEVPTGT CPVDPFEAQW AALENKSKQR TNPSPTNPFS SDLQKTFEIE L         10         20         30         40         50         60
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD ESRGMHICED
        70         80         90        100        110        120
AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE KTKDLIVDQT IEKVSFCAPD
       130        140        150        160        170        180
RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT GERLSHAVGC AFAACLERKQ KREKECGVTA
       190        200        210        220        230        240
TFDASRTTFT REGSFRVTTA TEQAEREEIM KQMQDAKKAE TDKIVVGSSV APGNTAPSPS
       250        260        270        280        290        300
SPTSPTSDAT TSLEMNNPHA IPRRHAPIEQ LARQGSFRGF PALSQKMSPF KRQLSLRINE
       310        320        330        340        350        360
LPSTMQRKTD FPIKNAVPEV EGEAESISSL CSQITNAFST PEDPFSSAPM TKPVTVVAPQ
       370        380        390        400        410        420
SPTFQANGTD SAFHVLAKPA HTALAPVAMP VRETNPWAHA PDAANKEIAA TCSGTEWGQS
       430        440        450        460        470        480
SGAASPGLFQ AGHRRTPSEA DRWLEEVSKS VRAQQPQASA APLQPVLQPP PPTAISQPAS
       490        500        510        520        530        540
PFQGNAFLTS QPVPVGVVPA LQPAFVPAQS YPVANGMPYP APNVPVVGIT PSQMVANVFG
       550        560        570        580        590        600
TAGHPQAAHP HQSPSLVRQQ TFPHYEASSA TTSPFFKPPA QHLNGSAAFN GVDDGRLASA
       610        620        630        640        650
DRHTEVPTGT CPVDPFEAQW AALENKSKQR TNPSPTNPFS SDLQKTFEIE L         10         20         30         40         50         60
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD ESRGMHICED
        70         80         90        100        110        120
AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE KTKDLIVDQT IEKVSFCAPD
       130        140        150        160        170        180
RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT GERLSHAVGC AFAACLERKQ KREKECGVTA
       190        200        210        220        230        240
TFDASRTTFT REGSFRVTTA TEQAEREEIM KQMQDAKKAE TDKIVVGSSV APGNTAPSPS
       250        260        270        280        290        300
SPTSPTSDAT TSLEMNNPHA IPRRHAPIEQ LARQGSFRGF PALSQKMSPF KRQLSLRINE
       310        320        330        340        350        360
LPSTMQRKTD FPIKNAVPEV EGEAESISSL CSQITNAFST PEDPFSSAPM TKPVTVVAPQ
       370        380        390        400        410        420
SPTFQANGTD SAFHVLAKPA HTALAPVAMP VRETNPWAHA PDAANKEIAA TCSGTEWGQS
       430        440        450        460        470        480
SGAASPGLFQ AGHRRTPSEA DRWLEEVSKS VRAQQPQASA APLQPVLQPP PPTAISQPAS
       490        500        510        520        530        540
PFQGNAFLTS QPVPVGVVPA LQPAFVPAQS YPVANGMPYP APNVPVVGIT PSQMVANVFG
       550        560        570        580        590        600
TAGHPQAAHP HQSPSLVRQQ TFPHYEASSA TTSPFFKPPA QHLNGSAAFN GVDDGRLASA
       610        620        630        640        650
DRHTEVPTGT CPVDPFEAQW AALENKSKQR TNPSPTNPFS SDLQKTFEIE L         10         20         30         40         50         60
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD ESRGMHICED
        70         80         90        100        110        120
AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE KTKDLIVDQT IEKVSFCAPD
       130        140        150        160        170        180
RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT GERLSHAVGC AFAACLERKQ KREKECGVTA
       190        200        210        220        230        240
TFDASRTTFT REGSFRVTTA TEQAEREEIM KQMQDAKKAE TDKIVVGSSV APGNTAPSPS
       250        260        270        280        290        300
SPTSPTSDAT TSLEMNNPHA IPRRHAPIEQ LARQGSFRGF PALSQKMSPF KRQLSLRINE
       310        320        330        340        350        360
LPSTMQRKTD FPIKNAVPEV EGEAESISSL CSQITNAFST PEDPFSSAPM TKPVTVVAPQ
       370        380        390        400        410        420
SPTFQANGTD SAFHVLAKPA HTALAPVAMP VRETNPWAHA PDAANKEIAA TCSGTEWGQS
       430        440        450        460        470        480
SGAASPGLFQ AGHRRTPSEA DRWLEEVSKS VRAQQPQASA APLQPVLQPP PPTAISQPAS
       490        500        510        520        530        540
PFQGNAFLTS QPVPVGVVPA LQPAFVPAQS YPVANGMPYP APNVPVVGIT PSQMVANVFG
       550        560        570        580        590        600
TAGHPQAAHP HQSPSLVRQQ TFPHYEASSA TTSPFFKPPA QHLNGSAAFN GVDDGRLASA
       610        620        630        640        650
DRHTEVPTGT CPVDPFEAQW AALENKSKQR TNPSPTNPFS SDLQKTFEIE L         10         20         30         40         50         60
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD ESRGMHICED
        70         80         90        100        110        120
AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE KTKDLIVDQT IEKVSFCAPD
       130        140        150        160        170        180
RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT GERLSHAVGC AFAACLERKQ KREKECGVTA
       190        200        210        220        230        240
TFDASRTTFT REGSFRVTTA TEQAEREEIM KQMQDAKKAE TDKIVVGSSV APGNTAPSPS
       250        260        270        280        290        300
SPTSPTSDAT TSLEMNNPHA IPRRHAPIEQ LARQGSFRGF PALSQKMSPF KRQLSLRINE
       310        320        330        340        350        360
LPSTMQRKTD FPIKNAVPEV EGEAESISSL CSQITNAFST PEDPFSSAPM TKPVTVVAPQ
       370        380        390        400        410        420
SPTFQANGTD SAFHVLAKPA HTALAPVAMP VRETNPWAHA PDAANKEIAA TCSGTEWGQS
       430        440        450        460        470        480
SGAASPGLFQ AGHRRTPSEA DRWLEEVSKS VRAQQPQASA APLQPVLQPP PPTAISQPAS
       490        500        510        520        530        540
PFQGNAFLTS QPVPVGVVPA LQPAFVPAQS YPVANGMPYP APNVPVVGIT PSQMVANVFG
       550        560        570        580        590        600
TAGHPQAAHP HQSPSLVRQQ TFPHYEASSA TTSPFFKPPA QHLNGSAAFN GVDDGRLASA
       610        620        630        640        650
DRHTEVPTGT CPVDPFEAQW AALENKSKQR TNPSPTNPFS SDLQKTFEIE L         10         20         30         40         50         60
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD ESRGMHICED
        70         80         90        100        110        120
AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE KTKDLIVDQT IEKVSFCAPD
       130        140        150        160        170        180
RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT GERLSHAVGC AFAACLERKQ KREKECGVTA
       190        200        210        220        230        240
TFDASRTTFT REGSFRVTTA TEQAEREEIM KQMQDAKKAE TDKIVVGSSV APGNTAPSPS
       250        260        270        280        290        300
SPTSPTSDAT TSLEMNNPHA IPRRHAPIEQ LARQGSFRGF PALSQKMSPF KRQLSLRINE
       310        320        330        340        350        360
LPSTMQRKTD FPIKNAVPEV EGEAESISSL CSQITNAFST PEDPFSSAPM TKPVTVVAPQ
       370        380        390        400        410        420
SPTFQANGTD SAFHVLAKPA HTALAPVAMP VRETNPWAHA PDAANKEIAA TCSGTEWGQS
       430        440        450        460        470        480
SGAASPGLFQ AGHRRTPSEA DRWLEEVSKS VRAQQPQASA APLQPVLQPP PPTAISQPAS
       490        500        510        520        530        540
PFQGNAFLTS QPVPVGVVPA LQPAFVPAQS YPVANGMPYP APNVPVVGIT PSQMVANVFG
       550        560        570        580        590        600
TAGHPQAAHP HQSPSLVRQQ TFPHYEASSA TTSPFFKPPA QHLNGSAAFN GVDDGRLASA
       610        620        630        640        650
DRHTEVPTGT CPVDPFEAQW AALENKSKQR TNPSPTNPFS SDLQKTFEIE L         10         20         30         40         50         60
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD ESRGMHICED
        70         80         90        100        110        120
AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE KTKDLIVDQT IEKVSFCAPD
       130        140        150        160        170        180
RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT GERLSHAVGC AFAACLERKQ KREKECGVTA
       190        200        210        220        230        240
TFDASRTTFT REGSFRVTTA TEQAEREEIM KQMQDAKKAE TDKIVVGSSV APGNTAPSPS
       250        260        270        280        290        300
SPTSPTSDAT TSLEMNNPHA IPRRHAPIEQ LARQGSFRGF PALSQKMSPF KRQLSLRINE
       310        320        330        340        350        360
LPSTMQRKTD FPIKNAVPEV EGEAESISSL CSQITNAFST PEDPFSSAPM TKPVTVVAPQ
       370        380        390        400        410        420
SPTFQANGTD SAFHVLAKPA HTALAPVAMP VRETNPWAHA PDAANKEIAA TCSGTEWGQS
       430        440        450        460        470        480
SGAASPGLFQ AGHRRTPSEA DRWLEEVSKS VRAQQPQASA APLQPVLQPP PPTAISQPAS
       490        500        510        520        530        540
PFQGNAFLTS QPVPVGVVPA LQPAFVPAQS YPVANGMPYP APNVPVVGIT PSQMVANVFG
       550        560        570        580        590        600
TAGHPQAAHP HQSPSLVRQQ TFPHYEASSA TTSPFFKPPA QHLNGSAAFN GVDDGRLASA
       610        620        630        640        650
DRHTEVPTGT CPVDPFEAQW AALENKSKQR TNPSPTNPFS SDLQKTFEIE L

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P49757-1-unknown	MNKLRQ...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49757-1-unknown	MNKLRQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83534
P49757-1-unknown	MNKLRQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83535
P49757-1-unknown	MNKLRQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83536
P49757-1-unknown	MNKLRQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83537
P49757-1-unknown	MNKLRQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83538
P49757-1-unknown	MNKLRQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83539
P49757-1-unknown	MNKLRQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83540
P49757-145-unknown	MAVKDT...	145	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451513
P49757-145-unknown	MAVKDT...	145	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197584
P49757-145-unknown	MAVKDT...	145	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197586
P49757-145-unknown	MAVKDT...	145	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197588
P49757-145-unknown	MAVKDT...	145	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197589
P49757-145-unknown	MAVKDT...	145	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197585
P49757-145-unknown	MAVKDT...	145	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197587
P49757-145-unknown	MAVKDT...	145	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197590
P49757-255-unknown	MNNPHA...	255	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83541
P49757-255-unknown	MNNPHA...	255	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100752
P49757-255-unknown	MNNPHA...	255	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100753
P49757-255-unknown	MNNPHA...	255	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100754
P49757-540-	GTAGHP...	540		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P49757-540-	GTAGHP...	540		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49757-540-unknown	GTAGHP...	540	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167789
P49757-540-unknown	GTAGHP...	540	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167790
P49757-540-unknown	GTAGHP...	540	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167791
P49757-540-unknown	GTAGHP...	540	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167792
P49757-540-unknown	GTAGHP...	540	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167793
P49757-540-unknown	GTAGHP...	540	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167794
P49757-540-unknown	GTAGHP...	540	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167796
P49757-540-unknown	GTAGHP...	540	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167795

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KRLKAE	67	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000451959
...KRLKAE	67	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153996
...KRLKAE	67	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153997
...KRLKAE	67	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153998
...KRLKAE	67	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153999
...KRLKAE	67	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154000
...KRLKAE	67	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154001
...KRLKAE	67	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154002
...EMNNPH	258	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452357
...EMNNPH	258	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000451374
...MNNPHA	259	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000451326
...FEIEL	651	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...FEIEL	651	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79159
...FEIEL	651	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79158
...FEIEL	651	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79157
...FEIEL	651	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79156
...FEIEL	651	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79155
...FEIEL	651	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79154
...FEIEL	651	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79152
...FEIEL	651	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79153

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)