TopFIND 4.0

P49759: Dual specificity protein kinase CLK1

General Information

Protein names
- Dual specificity protein kinase CLK1
- 2.7.12.1
- CDC-like kinase 1
Gene names CLK1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P49759

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MRHSKRTYCP DWDDKDWDYG KWRSSSSHKR RKRSHSSAQE NKRCKYNHSK MCDSHYLESR 
        70         80         90        100        110        120 
SINEKDYHSR RYIDEYRNDY TQGCEPGHRQ RDHESRYQNH SSKSSGRSGR SSYKSKHRIH 
       130        140        150        160        170        180 
HSTSHRRSHG KSHRRKRTRS VEDDEEGHLI CQSGDVLSAR YEIVDTLGEG AFGKVVECID 
       190        200        210        220        230        240 
HKAGGRHVAV KIVKNVDRYC EAARSEIQVL EHLNTTDPNS TFRCVQMLEW FEHHGHICIV 
       250        260        270        280        290        300 
FELLGLSTYD FIKENGFLPF RLDHIRKMAY QICKSVNFLH SNKLTHTDLK PENILFVQSD 
       310        320        330        340        350        360 
YTEAYNPKIK RDERTLINPD IKVVDFGSAT YDDEHHSTLV STRHYRAPEV ILALGWSQPC 
       370        380        390        400        410        420 
DVWSIGCILI EYYLGFTVFP THDSKEHLAM MERILGPLPK HMIQKTRKRK YFHHDRLDWD 
       430        440        450        460        470        480 
EHSSAGRYVS RRCKPLKEFM LSQDVEHERL FDLIQKMLEY DPAKRITLRE ALKHPFFDLL 
   
KKSI

Isoforms

- Isoform 2 of Dual specificity protein kinase CLK1 - Isoform 3 of Dual specificity protein kinase CLK1

Sequence View

        10         20         30         40         50         60 
MRHSKRTYCP DWDDKDWDYG KWRSSSSHKR RKRSHSSAQE NKRCKYNHSK MCDSHYLESR 
        70         80         90        100        110        120 
SINEKDYHSR RYIDEYRNDY TQGCEPGHRQ RDHESRYQNH SSKSSGRSGR SSYKSKHRIH 
       130        140        150        160        170        180 
HSTSHRRSHG KSHRRKRTRS VEDDEEGHLI CQSGDVLSAR YEIVDTLGEG AFGKVVECID 
       190        200        210        220        230        240 
HKAGGRHVAV KIVKNVDRYC EAARSEIQVL EHLNTTDPNS TFRCVQMLEW FEHHGHICIV 
       250        260        270        280        290        300 
FELLGLSTYD FIKENGFLPF RLDHIRKMAY QICKSVNFLH SNKLTHTDLK PENILFVQSD 
       310        320        330        340        350        360 
YTEAYNPKIK RDERTLINPD IKVVDFGSAT YDDEHHSTLV STRHYRAPEV ILALGWSQPC 
       370        380        390        400        410        420 
DVWSIGCILI EYYLGFTVFP THDSKEHLAM MERILGPLPK HMIQKTRKRK YFHHDRLDWD 
       430        440        450        460        470        480 
EHSSAGRYVS RRCKPLKEFM LSQDVEHERL FDLIQKMLEY DPAKRITLRE ALKHPFFDLL 
   
KKSI         10         20         30         40         50         60 
MRHSKRTYCP DWDDKDWDYG KWRSSSSHKR RKRSHSSAQE NKRCKYNHSK MCDSHYLESR 
        70         80         90        100        110        120 
SINEKDYHSR RYIDEYRNDY TQGCEPGHRQ RDHESRYQNH SSKSSGRSGR SSYKSKHRIH 
       130        140        150        160        170        180 
HSTSHRRSHG KSHRRKRTRS VEDDEEGHLI CQSGDVLSAR YEIVDTLGEG AFGKVVECID 
       190        200        210        220        230        240 
HKAGGRHVAV KIVKNVDRYC EAARSEIQVL EHLNTTDPNS TFRCVQMLEW FEHHGHICIV 
       250        260        270        280        290        300 
FELLGLSTYD FIKENGFLPF RLDHIRKMAY QICKSVNFLH SNKLTHTDLK PENILFVQSD 
       310        320        330        340        350        360 
YTEAYNPKIK RDERTLINPD IKVVDFGSAT YDDEHHSTLV STRHYRAPEV ILALGWSQPC 
       370        380        390        400        410        420 
DVWSIGCILI EYYLGFTVFP THDSKEHLAM MERILGPLPK HMIQKTRKRK YFHHDRLDWD 
       430        440        450        460        470        480 
EHSSAGRYVS RRCKPLKEFM LSQDVEHERL FDLIQKMLEY DPAKRITLRE ALKHPFFDLL 
   
KKSI



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P49759-1-unknown MRHSKR... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P49759-1-unknown MRHSKR... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt70973
    P49759-1-unknown MRHSKR... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt99250

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LKKSI 484 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...LKKSI 484 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt66592

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)