TopFIND 4.0

P49761: Dual specificity protein kinase CLK3

General Information

Protein names
- Dual specificity protein kinase CLK3
- 2.7.12.1
- CDC-like kinase 3
Gene names CLK3
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P49761

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MPVLSARRRE LADHAGSGRR SGPSPTARSG PHLSALRAQP ARAAHLSGRG TYVRRDTAGG 
        70         80         90        100        110        120 
GPGQARPLGP PGTSLLGRGA RRSGEGWCPG AFESGARAAR PPSRVEPRLA TAASREGAGL 
       130        140        150        160        170        180 
PRAEVAAGSG RGARSGEWGL AAAGAWETMH HCKRYRSPEP DPYLSYRWKR RRSYSREHEG 
       190        200        210        220        230        240 
RLRYPSRREP PPRRSRSRSH DRLPYQRRYR ERRDSDTYRC EERSPSFGED YYGPSRSRHR 
       250        260        270        280        290        300 
RRSRERGPYR TRKHAHHCHK RRTRSCSSAS SRSQQSSKRS SRSVEDDKEG HLVCRIGDWL 
       310        320        330        340        350        360 
QERYEIVGNL GEGTFGKVVE CLDHARGKSQ VALKIIRNVG KYREAARLEI NVLKKIKEKD 
       370        380        390        400        410        420 
KENKFLCVLM SDWFNFHGHM CIAFELLGKN TFEFLKENNF QPYPLPHVRH MAYQLCHALR 
       430        440        450        460        470        480 
FLHENQLTHT DLKPENILFV NSEFETLYNE HKSCEEKSVK NTSIRVADFG SATFDHEHHT 
       490        500        510        520        530        540 
TIVATRHYRP PEVILELGWA QPCDVWSIGC ILFEYYRGFT LFQTHENREH LVMMEKILGP 
       550        560        570        580        590        600 
IPSHMIHRTR KQKYFYKGGL VWDENSSDGR YVKENCKPLK SYMLQDSLEH VQLFDLMRRM 
       610        620        630    
LEFDPAQRIT LAEALLHPFF AGLTPEERSF HTSRNPSR

Isoforms

- Isoform 1 of Dual specificity protein kinase CLK3 - Isoform 2 of Dual specificity protein kinase CLK3 - Isoform 3 of Dual specificity protein kinase CLK3

Sequence View

        10         20         30         40         50         60 
MPVLSARRRE LADHAGSGRR SGPSPTARSG PHLSALRAQP ARAAHLSGRG TYVRRDTAGG 
        70         80         90        100        110        120 
GPGQARPLGP PGTSLLGRGA RRSGEGWCPG AFESGARAAR PPSRVEPRLA TAASREGAGL 
       130        140        150        160        170        180 
PRAEVAAGSG RGARSGEWGL AAAGAWETMH HCKRYRSPEP DPYLSYRWKR RRSYSREHEG 
       190        200        210        220        230        240 
RLRYPSRREP PPRRSRSRSH DRLPYQRRYR ERRDSDTYRC EERSPSFGED YYGPSRSRHR 
       250        260        270        280        290        300 
RRSRERGPYR TRKHAHHCHK RRTRSCSSAS SRSQQSSKRS SRSVEDDKEG HLVCRIGDWL 
       310        320        330        340        350        360 
QERYEIVGNL GEGTFGKVVE CLDHARGKSQ VALKIIRNVG KYREAARLEI NVLKKIKEKD 
       370        380        390        400        410        420 
KENKFLCVLM SDWFNFHGHM CIAFELLGKN TFEFLKENNF QPYPLPHVRH MAYQLCHALR 
       430        440        450        460        470        480 
FLHENQLTHT DLKPENILFV NSEFETLYNE HKSCEEKSVK NTSIRVADFG SATFDHEHHT 
       490        500        510        520        530        540 
TIVATRHYRP PEVILELGWA QPCDVWSIGC ILFEYYRGFT LFQTHENREH LVMMEKILGP 
       550        560        570        580        590        600 
IPSHMIHRTR KQKYFYKGGL VWDENSSDGR YVKENCKPLK SYMLQDSLEH VQLFDLMRRM 
       610        620        630    
LEFDPAQRIT LAEALLHPFF AGLTPEERSF HTSRNPSR         10         20         30         40         50         60 
MPVLSARRRE LADHAGSGRR SGPSPTARSG PHLSALRAQP ARAAHLSGRG TYVRRDTAGG 
        70         80         90        100        110        120 
GPGQARPLGP PGTSLLGRGA RRSGEGWCPG AFESGARAAR PPSRVEPRLA TAASREGAGL 
       130        140        150        160        170        180 
PRAEVAAGSG RGARSGEWGL AAAGAWETMH HCKRYRSPEP DPYLSYRWKR RRSYSREHEG 
       190        200        210        220        230        240 
RLRYPSRREP PPRRSRSRSH DRLPYQRRYR ERRDSDTYRC EERSPSFGED YYGPSRSRHR 
       250        260        270        280        290        300 
RRSRERGPYR TRKHAHHCHK RRTRSCSSAS SRSQQSSKRS SRSVEDDKEG HLVCRIGDWL 
       310        320        330        340        350        360 
QERYEIVGNL GEGTFGKVVE CLDHARGKSQ VALKIIRNVG KYREAARLEI NVLKKIKEKD 
       370        380        390        400        410        420 
KENKFLCVLM SDWFNFHGHM CIAFELLGKN TFEFLKENNF QPYPLPHVRH MAYQLCHALR 
       430        440        450        460        470        480 
FLHENQLTHT DLKPENILFV NSEFETLYNE HKSCEEKSVK NTSIRVADFG SATFDHEHHT 
       490        500        510        520        530        540 
TIVATRHYRP PEVILELGWA QPCDVWSIGC ILFEYYRGFT LFQTHENREH LVMMEKILGP 
       550        560        570        580        590        600 
IPSHMIHRTR KQKYFYKGGL VWDENSSDGR YVKENCKPLK SYMLQDSLEH VQLFDLMRRM 
       610        620        630    
LEFDPAQRIT LAEALLHPFF AGLTPEERSF HTSRNPSR         10         20         30         40         50         60 
MPVLSARRRE LADHAGSGRR SGPSPTARSG PHLSALRAQP ARAAHLSGRG TYVRRDTAGG 
        70         80         90        100        110        120 
GPGQARPLGP PGTSLLGRGA RRSGEGWCPG AFESGARAAR PPSRVEPRLA TAASREGAGL 
       130        140        150        160        170        180 
PRAEVAAGSG RGARSGEWGL AAAGAWETMH HCKRYRSPEP DPYLSYRWKR RRSYSREHEG 
       190        200        210        220        230        240 
RLRYPSRREP PPRRSRSRSH DRLPYQRRYR ERRDSDTYRC EERSPSFGED YYGPSRSRHR 
       250        260        270        280        290        300 
RRSRERGPYR TRKHAHHCHK RRTRSCSSAS SRSQQSSKRS SRSVEDDKEG HLVCRIGDWL 
       310        320        330        340        350        360 
QERYEIVGNL GEGTFGKVVE CLDHARGKSQ VALKIIRNVG KYREAARLEI NVLKKIKEKD 
       370        380        390        400        410        420 
KENKFLCVLM SDWFNFHGHM CIAFELLGKN TFEFLKENNF QPYPLPHVRH MAYQLCHALR 
       430        440        450        460        470        480 
FLHENQLTHT DLKPENILFV NSEFETLYNE HKSCEEKSVK NTSIRVADFG SATFDHEHHT 
       490        500        510        520        530        540 
TIVATRHYRP PEVILELGWA QPCDVWSIGC ILFEYYRGFT LFQTHENREH LVMMEKILGP 
       550        560        570        580        590        600 
IPSHMIHRTR KQKYFYKGGL VWDENSSDGR YVKENCKPLK SYMLQDSLEH VQLFDLMRRM 
       610        620        630    
LEFDPAQRIT LAEALLHPFF AGLTPEERSF HTSRNPSR



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Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P49761-1-unknown MPVLSA... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P49761-149-unknown MHHCKR... 149 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt70979
    P49761-149-unknown MHHCKR... 149 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt70980
    P49761-149-unknown MHHCKR... 149 inferred from electronic annotation unknown TISdb inferred from TISdb

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...RNPSR 638 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...RNPSR 638 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt66598

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)