P49816: Tuberin
| Protein names | - Tuberin - Tuberous sclerosis 2 protein homolog |
|---|---|
| Gene names | Tsc2 |
| Organism | Rattus norvegicus |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | P49816 |
1
N-termini
1
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MAKPTSKDSG LKEKFKILLG LGTSRPNPRC AEGKQTEFII TAEILRELSG ECGLNNRIRM
70 80 90 100 110 120
IGQICDVAKT KKLEEHAVEA LWKAVSDLLQ PERPPEARHA VLALLKAIVQ GQGDRLGVLR
130 140 150 160 170 180
ALFFKVIKDY PSNEDLHERL EVFKALTDNG RHITYLEEEL AEFVLQWMDV GLSSEFLLVL
190 200 210 220 230 240
VNLVKFNSCY LDEYIAPMVH MICLLCIRTV SSVDIEVSLQ VLDAVVCYNC LPAESLPLFI
250 260 270 280 290 300
ITLCRTVNVK ELCEPCWKLM RNLLGTHLGH SAIYNMCRIM ENRSYMEDAP LLRGAVFFVG
310 320 330 340 350 360
MALWGAHRLY SLKNSPTSVL PSFYEAMTCP NEVVSYEIVL SITRLIKKYR KELQAVTWDI
370 380 390 400 410 420
LLDIIERLLQ QLQNLDSPEL RTIVHDLLTT VEELCDQNEF HGSQERYYEL VESYADQRPE
430 440 450 460 470 480
SSLLNLITYR AQSIHPAKDG WIQNLQLLME RFFRNECRSA VRIKVLDVLS FVLLINRQFY
490 500 510 520 530 540
EEELINSVVI SQLSHIPEDK DHQVRKLATQ LLVDLAEGCH THHFNSLLDI IEKVMARSLS
550 560 570 580 590 600
PPLELEERDL AVYSASLEDV KTAVLGLLVI LQTKLYTLPA SHATRVYETL ISHIQLHYKH
610 620 630 640 650 660
GYSLPIASSI RLQAFDFLLL LRADSLHRLG LPNKDGVVRF SPYCLCDCAE LDRASEKKAS
670 680 690 700 710 720
GPLSPPTGPP SPVPTGPAVR LGHLPYSLLF RVLLQCLKQE TDWKVLKLVL SKLPESLRYK
730 740 750 760 770 780
VLIFTSPCSV DQLSSALCSM LSAPKTLERL RGTPEGFSRT DLHLAVVPVL TALISYHNYL
790 800 810 820 830 840
DKTRQREMVY CLEQGLIYRC ASQCVVALAI CSVEMPDIII KALPVLVVKL THISATASMA
850 860 870 880 890 900
IPLLEFLSTL ARLPHLYRNF AAEQYASVFA ISLPYTNPSK FNQYIVCLAH HVIAMWFIRC
910 920 930 940 950 960
RLPFRKDFVP YITKGLRSNV LLSFDDTPEK DKFRARSTSL NERPKSLRIA RAPKQGLNNS
970 980 990 1000 1010 1020
PPVKEFKESC AAEAFRCRSI SVSEHVVRSR IQTSLTSASL GSADENSMAQ ADDNLKNLHL
1030 1040 1050 1060 1070 1080
ELTETCLDMM ARYVFSNFTA VPKRSPVGEF LLAGGRTKTW LVGNKLVTVT TSVGTGTRSL
1090 1100 1110 1120 1130 1140
LGLDSGDLQG GSASSSDPGT HVRQTKEAPA KLESQAGQQV SRGARDRVRS MSGGHGLRVG
1150 1160 1170 1180 1190 1200
VLDTSAPYTP GGPASLGAQA APAARPEKPC AGAQLPAAEK ANLAAYVPLL TQGWAEILVR
1210 1220 1230 1240 1250 1260
RPTGNTSWLM SLENPLSPFS SDINNMPLQE LSNALMAAER FKEHRDTALY KSLSVPAAGT
1270 1280 1290 1300 1310 1320
AKPPTLPRSN TVASFSSLYQ PSCQGQLHRS VSWADSAVVL EEGSPGEAHV PVEPPELEDF
1330 1340 1350 1360 1370 1380
EAALGTDRHC QRPDAYSRSS SASSQEEKSH LEELAAGGIP IERAISSEGA RPTVDLSFQP
1390 1400 1410 1420 1430 1440
SQPLSKSSSS PELQTLQDIL GDLGDKTDIG RLSPEAKVRS QSGILDGEAA TWSAPGEESR
1450 1460 1470 1480 1490 1500
ITVPPEGPLP SSSPRSPSGL RPRGYTISDS APSRRGKRVE RDNFKSRTAA SSAEKVPGIN
1510 1520 1530 1540 1550 1560
PSFVFLQLYH SPFCGDESNK PILLPNESFE RSVQLLDQIP SYDTHKIAVL YVGEGQSSSE
1570 1580 1590 1600 1610 1620
LAILSNEHGS YRYTEFLTGL GRLIELKDCQ PDKVYLGGLD VCGEDGQFTY CWHDDIMQAV
1630 1640 1650 1660 1670 1680
FHIATLMPTK DVDKHRCDKK RHLGNDFVSI IYNDSGEDFK LGTIKGQFNF VHVIITPLDY
1690 1700 1710 1720 1730 1740
KCNLLTLQCR KDMEGLVDTS VAKIVSDRNL SFVARQMALH ANMASQVHHR RSNPTDIYPS
1750 1760 1770 1780 1790 1800
KWIARLRHIK RLRQRIREEV HYSNPSLPLM HPPAHTKVPA QAPTEATPTY ETGQRKRLIS
SVDDFTEFV
Isoforms
- Isoform 2 of Tuberin - Isoform 3 of Tuberin - Isoform 4 of TuberinSequence View
10 20 30 40 50 60
MAKPTSKDSG LKEKFKILLG LGTSRPNPRC AEGKQTEFII TAEILRELSG ECGLNNRIRM
70 80 90 100 110 120
IGQICDVAKT KKLEEHAVEA LWKAVSDLLQ PERPPEARHA VLALLKAIVQ GQGDRLGVLR
130 140 150 160 170 180
ALFFKVIKDY PSNEDLHERL EVFKALTDNG RHITYLEEEL AEFVLQWMDV GLSSEFLLVL
190 200 210 220 230 240
VNLVKFNSCY LDEYIAPMVH MICLLCIRTV SSVDIEVSLQ VLDAVVCYNC LPAESLPLFI
250 260 270 280 290 300
ITLCRTVNVK ELCEPCWKLM RNLLGTHLGH SAIYNMCRIM ENRSYMEDAP LLRGAVFFVG
310 320 330 340 350 360
MALWGAHRLY SLKNSPTSVL PSFYEAMTCP NEVVSYEIVL SITRLIKKYR KELQAVTWDI
370 380 390 400 410 420
LLDIIERLLQ QLQNLDSPEL RTIVHDLLTT VEELCDQNEF HGSQERYYEL VESYADQRPE
430 440 450 460 470 480
SSLLNLITYR AQSIHPAKDG WIQNLQLLME RFFRNECRSA VRIKVLDVLS FVLLINRQFY
490 500 510 520 530 540
EEELINSVVI SQLSHIPEDK DHQVRKLATQ LLVDLAEGCH THHFNSLLDI IEKVMARSLS
550 560 570 580 590 600
PPLELEERDL AVYSASLEDV KTAVLGLLVI LQTKLYTLPA SHATRVYETL ISHIQLHYKH
610 620 630 640 650 660
GYSLPIASSI RLQAFDFLLL LRADSLHRLG LPNKDGVVRF SPYCLCDCAE LDRASEKKAS
670 680 690 700 710 720
GPLSPPTGPP SPVPTGPAVR LGHLPYSLLF RVLLQCLKQE TDWKVLKLVL SKLPESLRYK
730 740 750 760 770 780
VLIFTSPCSV DQLSSALCSM LSAPKTLERL RGTPEGFSRT DLHLAVVPVL TALISYHNYL
790 800 810 820 830 840
DKTRQREMVY CLEQGLIYRC ASQCVVALAI CSVEMPDIII KALPVLVVKL THISATASMA
850 860 870 880 890 900
IPLLEFLSTL ARLPHLYRNF AAEQYASVFA ISLPYTNPSK FNQYIVCLAH HVIAMWFIRC
910 920 930 940 950 960
RLPFRKDFVP YITKGLRSNV LLSFDDTPEK DKFRARSTSL NERPKSLRIA RAPKQGLNNS
970 980 990 1000 1010 1020
PPVKEFKESC AAEAFRCRSI SVSEHVVRSR IQTSLTSASL GSADENSMAQ ADDNLKNLHL
1030 1040 1050 1060 1070 1080
ELTETCLDMM ARYVFSNFTA VPKRSPVGEF LLAGGRTKTW LVGNKLVTVT TSVGTGTRSL
1090 1100 1110 1120 1130 1140
LGLDSGDLQG GSASSSDPGT HVRQTKEAPA KLESQAGQQV SRGARDRVRS MSGGHGLRVG
1150 1160 1170 1180 1190 1200
VLDTSAPYTP GGPASLGAQA APAARPEKPC AGAQLPAAEK ANLAAYVPLL TQGWAEILVR
1210 1220 1230 1240 1250 1260
RPTGNTSWLM SLENPLSPFS SDINNMPLQE LSNALMAAER FKEHRDTALY KSLSVPAAGT
1270 1280 1290 1300 1310 1320
AKPPTLPRSN TVASFSSLYQ PSCQGQLHRS VSWADSAVVL EEGSPGEAHV PVEPPELEDF
1330 1340 1350 1360 1370 1380
EAALGTDRHC QRPDAYSRSS SASSQEEKSH LEELAAGGIP IERAISSEGA RPTVDLSFQP
1390 1400 1410 1420 1430 1440
SQPLSKSSSS PELQTLQDIL GDLGDKTDIG RLSPEAKVRS QSGILDGEAA TWSAPGEESR
1450 1460 1470 1480 1490 1500
ITVPPEGPLP SSSPRSPSGL RPRGYTISDS APSRRGKRVE RDNFKSRTAA SSAEKVPGIN
1510 1520 1530 1540 1550 1560
PSFVFLQLYH SPFCGDESNK PILLPNESFE RSVQLLDQIP SYDTHKIAVL YVGEGQSSSE
1570 1580 1590 1600 1610 1620
LAILSNEHGS YRYTEFLTGL GRLIELKDCQ PDKVYLGGLD VCGEDGQFTY CWHDDIMQAV
1630 1640 1650 1660 1670 1680
FHIATLMPTK DVDKHRCDKK RHLGNDFVSI IYNDSGEDFK LGTIKGQFNF VHVIITPLDY
1690 1700 1710 1720 1730 1740
KCNLLTLQCR KDMEGLVDTS VAKIVSDRNL SFVARQMALH ANMASQVHHR RSNPTDIYPS
1750 1760 1770 1780 1790 1800
KWIARLRHIK RLRQRIREEV HYSNPSLPLM HPPAHTKVPA QAPTEATPTY ETGQRKRLIS
SVDDFTEFV
10 20 30 40 50 60
MAKPTSKDSG LKEKFKILLG LGTSRPNPRC AEGKQTEFII TAEILRELSG ECGLNNRIRM
70 80 90 100 110 120
IGQICDVAKT KKLEEHAVEA LWKAVSDLLQ PERPPEARHA VLALLKAIVQ GQGDRLGVLR
130 140 150 160 170 180
ALFFKVIKDY PSNEDLHERL EVFKALTDNG RHITYLEEEL AEFVLQWMDV GLSSEFLLVL
190 200 210 220 230 240
VNLVKFNSCY LDEYIAPMVH MICLLCIRTV SSVDIEVSLQ VLDAVVCYNC LPAESLPLFI
250 260 270 280 290 300
ITLCRTVNVK ELCEPCWKLM RNLLGTHLGH SAIYNMCRIM ENRSYMEDAP LLRGAVFFVG
310 320 330 340 350 360
MALWGAHRLY SLKNSPTSVL PSFYEAMTCP NEVVSYEIVL SITRLIKKYR KELQAVTWDI
370 380 390 400 410 420
LLDIIERLLQ QLQNLDSPEL RTIVHDLLTT VEELCDQNEF HGSQERYYEL VESYADQRPE
430 440 450 460 470 480
SSLLNLITYR AQSIHPAKDG WIQNLQLLME RFFRNECRSA VRIKVLDVLS FVLLINRQFY
490 500 510 520 530 540
EEELINSVVI SQLSHIPEDK DHQVRKLATQ LLVDLAEGCH THHFNSLLDI IEKVMARSLS
550 560 570 580 590 600
PPLELEERDL AVYSASLEDV KTAVLGLLVI LQTKLYTLPA SHATRVYETL ISHIQLHYKH
610 620 630 640 650 660
GYSLPIASSI RLQAFDFLLL LRADSLHRLG LPNKDGVVRF SPYCLCDCAE LDRASEKKAS
670 680 690 700 710 720
GPLSPPTGPP SPVPTGPAVR LGHLPYSLLF RVLLQCLKQE TDWKVLKLVL SKLPESLRYK
730 740 750 760 770 780
VLIFTSPCSV DQLSSALCSM LSAPKTLERL RGTPEGFSRT DLHLAVVPVL TALISYHNYL
790 800 810 820 830 840
DKTRQREMVY CLEQGLIYRC ASQCVVALAI CSVEMPDIII KALPVLVVKL THISATASMA
850 860 870 880 890 900
IPLLEFLSTL ARLPHLYRNF AAEQYASVFA ISLPYTNPSK FNQYIVCLAH HVIAMWFIRC
910 920 930 940 950 960
RLPFRKDFVP YITKGLRSNV LLSFDDTPEK DKFRARSTSL NERPKSLRIA RAPKQGLNNS
970 980 990 1000 1010 1020
PPVKEFKESC AAEAFRCRSI SVSEHVVRSR IQTSLTSASL GSADENSMAQ ADDNLKNLHL
1030 1040 1050 1060 1070 1080
ELTETCLDMM ARYVFSNFTA VPKRSPVGEF LLAGGRTKTW LVGNKLVTVT TSVGTGTRSL
1090 1100 1110 1120 1130 1140
LGLDSGDLQG GSASSSDPGT HVRQTKEAPA KLESQAGQQV SRGARDRVRS MSGGHGLRVG
1150 1160 1170 1180 1190 1200
VLDTSAPYTP GGPASLGAQA APAARPEKPC AGAQLPAAEK ANLAAYVPLL TQGWAEILVR
1210 1220 1230 1240 1250 1260
RPTGNTSWLM SLENPLSPFS SDINNMPLQE LSNALMAAER FKEHRDTALY KSLSVPAAGT
1270 1280 1290 1300 1310 1320
AKPPTLPRSN TVASFSSLYQ PSCQGQLHRS VSWADSAVVL EEGSPGEAHV PVEPPELEDF
1330 1340 1350 1360 1370 1380
EAALGTDRHC QRPDAYSRSS SASSQEEKSH LEELAAGGIP IERAISSEGA RPTVDLSFQP
1390 1400 1410 1420 1430 1440
SQPLSKSSSS PELQTLQDIL GDLGDKTDIG RLSPEAKVRS QSGILDGEAA TWSAPGEESR
1450 1460 1470 1480 1490 1500
ITVPPEGPLP SSSPRSPSGL RPRGYTISDS APSRRGKRVE RDNFKSRTAA SSAEKVPGIN
1510 1520 1530 1540 1550 1560
PSFVFLQLYH SPFCGDESNK PILLPNESFE RSVQLLDQIP SYDTHKIAVL YVGEGQSSSE
1570 1580 1590 1600 1610 1620
LAILSNEHGS YRYTEFLTGL GRLIELKDCQ PDKVYLGGLD VCGEDGQFTY CWHDDIMQAV
1630 1640 1650 1660 1670 1680
FHIATLMPTK DVDKHRCDKK RHLGNDFVSI IYNDSGEDFK LGTIKGQFNF VHVIITPLDY
1690 1700 1710 1720 1730 1740
KCNLLTLQCR KDMEGLVDTS VAKIVSDRNL SFVARQMALH ANMASQVHHR RSNPTDIYPS
1750 1760 1770 1780 1790 1800
KWIARLRHIK RLRQRIREEV HYSNPSLPLM HPPAHTKVPA QAPTEATPTY ETGQRKRLIS
SVDDFTEFV
10 20 30 40 50 60
MAKPTSKDSG LKEKFKILLG LGTSRPNPRC AEGKQTEFII TAEILRELSG ECGLNNRIRM
70 80 90 100 110 120
IGQICDVAKT KKLEEHAVEA LWKAVSDLLQ PERPPEARHA VLALLKAIVQ GQGDRLGVLR
130 140 150 160 170 180
ALFFKVIKDY PSNEDLHERL EVFKALTDNG RHITYLEEEL AEFVLQWMDV GLSSEFLLVL
190 200 210 220 230 240
VNLVKFNSCY LDEYIAPMVH MICLLCIRTV SSVDIEVSLQ VLDAVVCYNC LPAESLPLFI
250 260 270 280 290 300
ITLCRTVNVK ELCEPCWKLM RNLLGTHLGH SAIYNMCRIM ENRSYMEDAP LLRGAVFFVG
310 320 330 340 350 360
MALWGAHRLY SLKNSPTSVL PSFYEAMTCP NEVVSYEIVL SITRLIKKYR KELQAVTWDI
370 380 390 400 410 420
LLDIIERLLQ QLQNLDSPEL RTIVHDLLTT VEELCDQNEF HGSQERYYEL VESYADQRPE
430 440 450 460 470 480
SSLLNLITYR AQSIHPAKDG WIQNLQLLME RFFRNECRSA VRIKVLDVLS FVLLINRQFY
490 500 510 520 530 540
EEELINSVVI SQLSHIPEDK DHQVRKLATQ LLVDLAEGCH THHFNSLLDI IEKVMARSLS
550 560 570 580 590 600
PPLELEERDL AVYSASLEDV KTAVLGLLVI LQTKLYTLPA SHATRVYETL ISHIQLHYKH
610 620 630 640 650 660
GYSLPIASSI RLQAFDFLLL LRADSLHRLG LPNKDGVVRF SPYCLCDCAE LDRASEKKAS
670 680 690 700 710 720
GPLSPPTGPP SPVPTGPAVR LGHLPYSLLF RVLLQCLKQE TDWKVLKLVL SKLPESLRYK
730 740 750 760 770 780
VLIFTSPCSV DQLSSALCSM LSAPKTLERL RGTPEGFSRT DLHLAVVPVL TALISYHNYL
790 800 810 820 830 840
DKTRQREMVY CLEQGLIYRC ASQCVVALAI CSVEMPDIII KALPVLVVKL THISATASMA
850 860 870 880 890 900
IPLLEFLSTL ARLPHLYRNF AAEQYASVFA ISLPYTNPSK FNQYIVCLAH HVIAMWFIRC
910 920 930 940 950 960
RLPFRKDFVP YITKGLRSNV LLSFDDTPEK DKFRARSTSL NERPKSLRIA RAPKQGLNNS
970 980 990 1000 1010 1020
PPVKEFKESC AAEAFRCRSI SVSEHVVRSR IQTSLTSASL GSADENSMAQ ADDNLKNLHL
1030 1040 1050 1060 1070 1080
ELTETCLDMM ARYVFSNFTA VPKRSPVGEF LLAGGRTKTW LVGNKLVTVT TSVGTGTRSL
1090 1100 1110 1120 1130 1140
LGLDSGDLQG GSASSSDPGT HVRQTKEAPA KLESQAGQQV SRGARDRVRS MSGGHGLRVG
1150 1160 1170 1180 1190 1200
VLDTSAPYTP GGPASLGAQA APAARPEKPC AGAQLPAAEK ANLAAYVPLL TQGWAEILVR
1210 1220 1230 1240 1250 1260
RPTGNTSWLM SLENPLSPFS SDINNMPLQE LSNALMAAER FKEHRDTALY KSLSVPAAGT
1270 1280 1290 1300 1310 1320
AKPPTLPRSN TVASFSSLYQ PSCQGQLHRS VSWADSAVVL EEGSPGEAHV PVEPPELEDF
1330 1340 1350 1360 1370 1380
EAALGTDRHC QRPDAYSRSS SASSQEEKSH LEELAAGGIP IERAISSEGA RPTVDLSFQP
1390 1400 1410 1420 1430 1440
SQPLSKSSSS PELQTLQDIL GDLGDKTDIG RLSPEAKVRS QSGILDGEAA TWSAPGEESR
1450 1460 1470 1480 1490 1500
ITVPPEGPLP SSSPRSPSGL RPRGYTISDS APSRRGKRVE RDNFKSRTAA SSAEKVPGIN
1510 1520 1530 1540 1550 1560
PSFVFLQLYH SPFCGDESNK PILLPNESFE RSVQLLDQIP SYDTHKIAVL YVGEGQSSSE
1570 1580 1590 1600 1610 1620
LAILSNEHGS YRYTEFLTGL GRLIELKDCQ PDKVYLGGLD VCGEDGQFTY CWHDDIMQAV
1630 1640 1650 1660 1670 1680
FHIATLMPTK DVDKHRCDKK RHLGNDFVSI IYNDSGEDFK LGTIKGQFNF VHVIITPLDY
1690 1700 1710 1720 1730 1740
KCNLLTLQCR KDMEGLVDTS VAKIVSDRNL SFVARQMALH ANMASQVHHR RSNPTDIYPS
1750 1760 1770 1780 1790 1800
KWIARLRHIK RLRQRIREEV HYSNPSLPLM HPPAHTKVPA QAPTEATPTY ETGQRKRLIS
SVDDFTEFV
Protein Neighborhood
Domains & Features
1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| P49816-1-unknown | MAKPTS... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P49816-1-unknown | MAKPTS... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt193663 | |||
| P49816-1-unknown | MAKPTS... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt193664 | |||
| P49816-1-unknown | MAKPTS... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt193665 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...FTEFV | 1809 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...FTEFV | 1809 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt153611 | |||
| ...FTEFV | 1809 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt153609 | |||
| ...FTEFV | 1809 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt153610 |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|