P49841: Glycogen synthase kinase-3 beta

General Information

Protein names	- Glycogen synthase kinase-3 beta - GSK-3 beta - 2.7.11.26 - Serine/threonine-protein kinase GSK3B - 2.7.11.1 {ECO:0000269\|PubMed:22539723}
Gene names	GSK3B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49841

2 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK
        70         80         90        100        110        120
VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG
       130        140        150        160        170        180
EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR
       190        200        210        220        230        240
DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV
       250        260        270        280        290        300
WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP
       310        320        330        340        350        360
WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL PNGRDTPALF
       370        380        390        400        410        420
NFTTQELSSN PPLATILIPP HARIQAAAST PTNATAASDA NTGDRGQTNN AASASASNST

Isoforms

- Isoform 2 of Glycogen synthase kinase-3 beta

Sequence View

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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P49841-1-unknown	MSGRPR...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P49841-1-unknown	MSGRPR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76580
P49841-11-unknown	AESCKP...	11		unknown		Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P49841-11-unknown	AESCKP...	11	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt159693

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...ASNST	420	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...ASNST	420	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt72198
...ASNST	420		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...ASNST	420		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...ASNST	420		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...ASNST	420		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)