P49895: Type I iodothyronine deiodinase

General Information

Protein names	- Type I iodothyronine deiodinase - 1.21.99.4 - 5DI - DIOI - Type 1 DI - Type-I 5'-deiodinase
Gene names	DIO1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49895

1 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Type I iodothyronine deiodinase - Isoform 3 of Type I iodothyronine deiodinase - Isoform 4 of Type I iodothyronine deiodinase - Isoform 5 of Type I iodothyronine deiodinase - Isoform 6 of Type I iodothyronine deiodinase - Isoform 7 of Type I iodothyronine deiodinase - Isoform 8 of Type I iodothyronine deiodinase - Isoform 9 of Type I iodothyronine deiodinase

Sequence View

        10         20         30         40         50         60
MGLPQPGLWL KRLWVLLEVA VHVVVGKVLL ILFPDRVKRN ILAMGEKTGM TRNPHFSHDN
        70         80         90        100        110        120
WIPTFFSTQY FWFVLKVRWQ RLEDTTELGG LAPNCPVVRL SGQRCNIWEF MQGNRPLVLN
       130        140        150        160        170        180
FGSCTUPSFM FKFDQFKRLI EDFSSIADFL VIYIEEAHAS DGWAFKNNMD IRNHQNLQDR
       190        200        210        220        230        240
LQAAHLLLAR SPQCPVVVDT MQNQSSQLYA ALPERLYIIQ EGRILYKGKS GPWNYNPEEV

RAVLEKLHS         10         20         30         40         50         60
MGLPQPGLWL KRLWVLLEVA VHVVVGKVLL ILFPDRVKRN ILAMGEKTGM TRNPHFSHDN
        70         80         90        100        110        120
WIPTFFSTQY FWFVLKVRWQ RLEDTTELGG LAPNCPVVRL SGQRCNIWEF MQGNRPLVLN
       130        140        150        160        170        180
FGSCTUPSFM FKFDQFKRLI EDFSSIADFL VIYIEEAHAS DGWAFKNNMD IRNHQNLQDR
       190        200        210        220        230        240
LQAAHLLLAR SPQCPVVVDT MQNQSSQLYA ALPERLYIIQ EGRILYKGKS GPWNYNPEEV

RAVLEKLHS         10         20         30         40         50         60
MGLPQPGLWL KRLWVLLEVA VHVVVGKVLL ILFPDRVKRN ILAMGEKTGM TRNPHFSHDN
        70         80         90        100        110        120
WIPTFFSTQY FWFVLKVRWQ RLEDTTELGG LAPNCPVVRL SGQRCNIWEF MQGNRPLVLN
       130        140        150        160        170        180
FGSCTUPSFM FKFDQFKRLI EDFSSIADFL VIYIEEAHAS DGWAFKNNMD IRNHQNLQDR
       190        200        210        220        230        240
LQAAHLLLAR SPQCPVVVDT MQNQSSQLYA ALPERLYIIQ EGRILYKGKS GPWNYNPEEV

RAVLEKLHS         10         20         30         40         50         60
MGLPQPGLWL KRLWVLLEVA VHVVVGKVLL ILFPDRVKRN ILAMGEKTGM TRNPHFSHDN
        70         80         90        100        110        120
WIPTFFSTQY FWFVLKVRWQ RLEDTTELGG LAPNCPVVRL SGQRCNIWEF MQGNRPLVLN
       130        140        150        160        170        180
FGSCTUPSFM FKFDQFKRLI EDFSSIADFL VIYIEEAHAS DGWAFKNNMD IRNHQNLQDR
       190        200        210        220        230        240
LQAAHLLLAR SPQCPVVVDT MQNQSSQLYA ALPERLYIIQ EGRILYKGKS GPWNYNPEEV

RAVLEKLHS         10         20         30         40         50         60
MGLPQPGLWL KRLWVLLEVA VHVVVGKVLL ILFPDRVKRN ILAMGEKTGM TRNPHFSHDN
        70         80         90        100        110        120
WIPTFFSTQY FWFVLKVRWQ RLEDTTELGG LAPNCPVVRL SGQRCNIWEF MQGNRPLVLN
       130        140        150        160        170        180
FGSCTUPSFM FKFDQFKRLI EDFSSIADFL VIYIEEAHAS DGWAFKNNMD IRNHQNLQDR
       190        200        210        220        230        240
LQAAHLLLAR SPQCPVVVDT MQNQSSQLYA ALPERLYIIQ EGRILYKGKS GPWNYNPEEV

RAVLEKLHS         10         20         30         40         50         60
MGLPQPGLWL KRLWVLLEVA VHVVVGKVLL ILFPDRVKRN ILAMGEKTGM TRNPHFSHDN
        70         80         90        100        110        120
WIPTFFSTQY FWFVLKVRWQ RLEDTTELGG LAPNCPVVRL SGQRCNIWEF MQGNRPLVLN
       130        140        150        160        170        180
FGSCTUPSFM FKFDQFKRLI EDFSSIADFL VIYIEEAHAS DGWAFKNNMD IRNHQNLQDR
       190        200        210        220        230        240
LQAAHLLLAR SPQCPVVVDT MQNQSSQLYA ALPERLYIIQ EGRILYKGKS GPWNYNPEEV

RAVLEKLHS         10         20         30         40         50         60
MGLPQPGLWL KRLWVLLEVA VHVVVGKVLL ILFPDRVKRN ILAMGEKTGM TRNPHFSHDN
        70         80         90        100        110        120
WIPTFFSTQY FWFVLKVRWQ RLEDTTELGG LAPNCPVVRL SGQRCNIWEF MQGNRPLVLN
       130        140        150        160        170        180
FGSCTUPSFM FKFDQFKRLI EDFSSIADFL VIYIEEAHAS DGWAFKNNMD IRNHQNLQDR
       190        200        210        220        230        240
LQAAHLLLAR SPQCPVVVDT MQNQSSQLYA ALPERLYIIQ EGRILYKGKS GPWNYNPEEV

RAVLEKLHS         10         20         30         40         50         60
MGLPQPGLWL KRLWVLLEVA VHVVVGKVLL ILFPDRVKRN ILAMGEKTGM TRNPHFSHDN
        70         80         90        100        110        120
WIPTFFSTQY FWFVLKVRWQ RLEDTTELGG LAPNCPVVRL SGQRCNIWEF MQGNRPLVLN
       130        140        150        160        170        180
FGSCTUPSFM FKFDQFKRLI EDFSSIADFL VIYIEEAHAS DGWAFKNNMD IRNHQNLQDR
       190        200        210        220        230        240
LQAAHLLLAR SPQCPVVVDT MQNQSSQLYA ALPERLYIIQ EGRILYKGKS GPWNYNPEEV

RAVLEKLHS

Protein Neighborhood

Domains & Features

1 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P49895-1-unknown	MGLPQP...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P49895-1-unknown	MGLPQP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77978
P49895-1-unknown	MGLPQP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77979
P49895-1-unknown	MGLPQP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77980
P49895-1-unknown	MGLPQP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77981
P49895-1-unknown	MGLPQP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77982
P49895-1-unknown	MGLPQP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77983
P49895-1-unknown	MGLPQP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77984
P49895-1-unknown	MGLPQP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77985

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EFMQGN	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73601
...EFMQGN	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91539
...EKLHS	249	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EKLHS	249	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73596
...EKLHS	249	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73598

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

TopFIND

P49895: Type I iodothyronine deiodinase

General Information

1

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

1 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates