P49961: Ectonucleoside triphosphate diphosphohydrolase 1

General Information

Protein names	- Ectonucleoside triphosphate diphosphohydrolase 1 - NTPDase 1 - 3.6.1.5 - Ecto-ATP diphosphohydrolase 1 - Ecto-ATPDase 1 - Ecto-ATPase 1 - Ecto-apyrase - Lymphoid cell activation antigen - CD39
Gene names	ENTPD1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49961

3 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Ectonucleoside triphosphate diphosphohydrolase 1 - Isoform 3 of Ectonucleoside triphosphate diphosphohydrolase 1 - Isoform 4 of Ectonucleoside triphosphate diphosphohydrolase 1 - Isoform 5 of Ectonucleoside triphosphate diphosphohydrolase 1 - Isoform 6 of Ectonucleoside triphosphate diphosphohydrolase 1

Sequence View

        10         20         30         40         50         60
MEDTKESNVK TFCSKNILAI LGFSSIIAVI ALLAVGLTQN KALPENVKYG IVLDAGSSHT
        70         80         90        100        110        120
SLYIYKWPAE KENDTGVVHQ VEECRVKGPG ISKFVQKVNE IGIYLTDCME RAREVIPRSQ
       130        140        150        160        170        180
HQETPVYLGA TAGMRLLRME SEELADRVLD VVERSLSNYP FDFQGARIIT GQEEGAYGWI
       190        200        210        220        230        240
TINYLLGKFS QKTRWFSIVP YETNNQETFG ALDLGGASTQ VTFVPQNQTI ESPDNALQFR
       250        260        270        280        290        300
LYGKDYNVYT HSFLCYGKDQ ALWQKLAKDI QVASNEILRD PCFHPGYKKV VNVSDLYKTP
       310        320        330        340        350        360
CTKRFEMTLP FQQFEIQGIG NYQQCHQSIL ELFNTSYCPY SQCAFNGIFL PPLQGDFGAF
       370        380        390        400        410        420
SAFYFVMKFL NLTSEKVSQE KVTEMMKKFC AQPWEEIKTS YAGVKEKYLS EYCFSGTYIL
       430        440        450        460        470        480
SLLLQGYHFT ADSWEHIHFI GKIQGSDAGW TLGYMLNLTN MIPAEQPLST PLSHSTYVFL
       490        500        510
MVLFSLVLFT VAIIGLLIFH KPSYFWKDMV         10         20         30         40         50         60
MEDTKESNVK TFCSKNILAI LGFSSIIAVI ALLAVGLTQN KALPENVKYG IVLDAGSSHT
        70         80         90        100        110        120
SLYIYKWPAE KENDTGVVHQ VEECRVKGPG ISKFVQKVNE IGIYLTDCME RAREVIPRSQ
       130        140        150        160        170        180
HQETPVYLGA TAGMRLLRME SEELADRVLD VVERSLSNYP FDFQGARIIT GQEEGAYGWI
       190        200        210        220        230        240
TINYLLGKFS QKTRWFSIVP YETNNQETFG ALDLGGASTQ VTFVPQNQTI ESPDNALQFR
       250        260        270        280        290        300
LYGKDYNVYT HSFLCYGKDQ ALWQKLAKDI QVASNEILRD PCFHPGYKKV VNVSDLYKTP
       310        320        330        340        350        360
CTKRFEMTLP FQQFEIQGIG NYQQCHQSIL ELFNTSYCPY SQCAFNGIFL PPLQGDFGAF
       370        380        390        400        410        420
SAFYFVMKFL NLTSEKVSQE KVTEMMKKFC AQPWEEIKTS YAGVKEKYLS EYCFSGTYIL
       430        440        450        460        470        480
SLLLQGYHFT ADSWEHIHFI GKIQGSDAGW TLGYMLNLTN MIPAEQPLST PLSHSTYVFL
       490        500        510
MVLFSLVLFT VAIIGLLIFH KPSYFWKDMV         10         20         30         40         50         60
MEDTKESNVK TFCSKNILAI LGFSSIIAVI ALLAVGLTQN KALPENVKYG IVLDAGSSHT
        70         80         90        100        110        120
SLYIYKWPAE KENDTGVVHQ VEECRVKGPG ISKFVQKVNE IGIYLTDCME RAREVIPRSQ
       130        140        150        160        170        180
HQETPVYLGA TAGMRLLRME SEELADRVLD VVERSLSNYP FDFQGARIIT GQEEGAYGWI
       190        200        210        220        230        240
TINYLLGKFS QKTRWFSIVP YETNNQETFG ALDLGGASTQ VTFVPQNQTI ESPDNALQFR
       250        260        270        280        290        300
LYGKDYNVYT HSFLCYGKDQ ALWQKLAKDI QVASNEILRD PCFHPGYKKV VNVSDLYKTP
       310        320        330        340        350        360
CTKRFEMTLP FQQFEIQGIG NYQQCHQSIL ELFNTSYCPY SQCAFNGIFL PPLQGDFGAF
       370        380        390        400        410        420
SAFYFVMKFL NLTSEKVSQE KVTEMMKKFC AQPWEEIKTS YAGVKEKYLS EYCFSGTYIL
       430        440        450        460        470        480
SLLLQGYHFT ADSWEHIHFI GKIQGSDAGW TLGYMLNLTN MIPAEQPLST PLSHSTYVFL
       490        500        510
MVLFSLVLFT VAIIGLLIFH KPSYFWKDMV         10         20         30         40         50         60
MEDTKESNVK TFCSKNILAI LGFSSIIAVI ALLAVGLTQN KALPENVKYG IVLDAGSSHT
        70         80         90        100        110        120
SLYIYKWPAE KENDTGVVHQ VEECRVKGPG ISKFVQKVNE IGIYLTDCME RAREVIPRSQ
       130        140        150        160        170        180
HQETPVYLGA TAGMRLLRME SEELADRVLD VVERSLSNYP FDFQGARIIT GQEEGAYGWI
       190        200        210        220        230        240
TINYLLGKFS QKTRWFSIVP YETNNQETFG ALDLGGASTQ VTFVPQNQTI ESPDNALQFR
       250        260        270        280        290        300
LYGKDYNVYT HSFLCYGKDQ ALWQKLAKDI QVASNEILRD PCFHPGYKKV VNVSDLYKTP
       310        320        330        340        350        360
CTKRFEMTLP FQQFEIQGIG NYQQCHQSIL ELFNTSYCPY SQCAFNGIFL PPLQGDFGAF
       370        380        390        400        410        420
SAFYFVMKFL NLTSEKVSQE KVTEMMKKFC AQPWEEIKTS YAGVKEKYLS EYCFSGTYIL
       430        440        450        460        470        480
SLLLQGYHFT ADSWEHIHFI GKIQGSDAGW TLGYMLNLTN MIPAEQPLST PLSHSTYVFL
       490        500        510
MVLFSLVLFT VAIIGLLIFH KPSYFWKDMV         10         20         30         40         50         60
MEDTKESNVK TFCSKNILAI LGFSSIIAVI ALLAVGLTQN KALPENVKYG IVLDAGSSHT
        70         80         90        100        110        120
SLYIYKWPAE KENDTGVVHQ VEECRVKGPG ISKFVQKVNE IGIYLTDCME RAREVIPRSQ
       130        140        150        160        170        180
HQETPVYLGA TAGMRLLRME SEELADRVLD VVERSLSNYP FDFQGARIIT GQEEGAYGWI
       190        200        210        220        230        240
TINYLLGKFS QKTRWFSIVP YETNNQETFG ALDLGGASTQ VTFVPQNQTI ESPDNALQFR
       250        260        270        280        290        300
LYGKDYNVYT HSFLCYGKDQ ALWQKLAKDI QVASNEILRD PCFHPGYKKV VNVSDLYKTP
       310        320        330        340        350        360
CTKRFEMTLP FQQFEIQGIG NYQQCHQSIL ELFNTSYCPY SQCAFNGIFL PPLQGDFGAF
       370        380        390        400        410        420
SAFYFVMKFL NLTSEKVSQE KVTEMMKKFC AQPWEEIKTS YAGVKEKYLS EYCFSGTYIL
       430        440        450        460        470        480
SLLLQGYHFT ADSWEHIHFI GKIQGSDAGW TLGYMLNLTN MIPAEQPLST PLSHSTYVFL
       490        500        510
MVLFSLVLFT VAIIGLLIFH KPSYFWKDMV

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P49961-1-unknown	MEDTKE...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P49961-109-unknown	MERARE...	109	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73972
P49961-109-unknown	MERARE...	109	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109423
P49961-109-unknown	MERARE...	109	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109424
P49961-109-unknown	MERARE...	109	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109422
P49961-109-unknown	MERARE...	109	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P49961-109-unknown	MERARE...	109	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P49961-139-unknown	MESEEL...	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73971
P49961-139-unknown	MESEEL...	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109371
P49961-139-unknown	MESEEL...	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109372
P49961-139-unknown	MESEEL...	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109373
P49961-139-unknown	MESEEL...	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109370

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...WKDMV	510	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...WKDMV	510	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69589
...WKDMV	510	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69590
...WKDMV	510	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69587
...WKDMV	510	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69591

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)