TopFIND 4.0

P50135: Histamine N-methyltransferase

General Information

Protein names
- Histamine N-methyltransferase
- HMT
- 2.1.1.8 {ECO:0000269|PubMed:26206890}
Gene names HNMT
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P50135

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MASSMRSLFS DHGKYVESFR RFLNHSTEHQ CMQEFMDKKL PGIIGRIGDT KSEIKILSIG 
        70         80         90        100        110        120 
GGAGEIDLQI LSKVQAQYPG VCINNEVVEP SAEQIAKYKE LVAKTSNLEN VKFAWHKETS 
       130        140        150        160        170        180 
SEYQSRMLEK KELQKWDFIH MIQMLYYVKD IPATLKFFHS LLGTNAKMLI IVVSGSSGWD 
       190        200        210        220        230        240 
KLWKKYGSRF PQDDLCQYIT SDDLTQMLDN LGLKYECYDL LSTMDISDCF IDGNENGDLL 
       250        260        270        280        290    
WDFLTETCNF NATAPPDLRA ELGKDLQEPE FSAKKEGKVL FNNTLSFIVI EA

Isoforms

- Isoform 2 of Histamine N-methyltransferase - Isoform 3 of Histamine N-methyltransferase

Sequence View

        10         20         30         40         50         60 
MASSMRSLFS DHGKYVESFR RFLNHSTEHQ CMQEFMDKKL PGIIGRIGDT KSEIKILSIG 
        70         80         90        100        110        120 
GGAGEIDLQI LSKVQAQYPG VCINNEVVEP SAEQIAKYKE LVAKTSNLEN VKFAWHKETS 
       130        140        150        160        170        180 
SEYQSRMLEK KELQKWDFIH MIQMLYYVKD IPATLKFFHS LLGTNAKMLI IVVSGSSGWD 
       190        200        210        220        230        240 
KLWKKYGSRF PQDDLCQYIT SDDLTQMLDN LGLKYECYDL LSTMDISDCF IDGNENGDLL 
       250        260        270        280        290    
WDFLTETCNF NATAPPDLRA ELGKDLQEPE FSAKKEGKVL FNNTLSFIVI EA         10         20         30         40         50         60 
MASSMRSLFS DHGKYVESFR RFLNHSTEHQ CMQEFMDKKL PGIIGRIGDT KSEIKILSIG 
        70         80         90        100        110        120 
GGAGEIDLQI LSKVQAQYPG VCINNEVVEP SAEQIAKYKE LVAKTSNLEN VKFAWHKETS 
       130        140        150        160        170        180 
SEYQSRMLEK KELQKWDFIH MIQMLYYVKD IPATLKFFHS LLGTNAKMLI IVVSGSSGWD 
       190        200        210        220        230        240 
KLWKKYGSRF PQDDLCQYIT SDDLTQMLDN LGLKYECYDL LSTMDISDCF IDGNENGDLL 
       250        260        270        280        290    
WDFLTETCNF NATAPPDLRA ELGKDLQEPE FSAKKEGKVL FNNTLSFIVI EA



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P50135-1-unknown MASSMR... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P50135-1-unknown MASSMR... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt77140
    P50135-1-unknown MASSMR... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt77141

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...IVIEA 292 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)