TopFIND 4.0

P50545: Tyrosine-protein kinase HCK

General Information

Protein names
- Tyrosine-protein kinase HCK
- 2.7.10.2
- Hematopoietic cell kinase
- Hemopoietic cell kinase
- p56-HCK
- p56Hck
- p59Hck
Gene names Hck
Organism Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID P50545

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGGRSSCEDP GCPRGEGRVP RMGCVKSRFL REGSKASKIE PNANQKGPVY VPDPTSPKKL 
        70         80         90        100        110        120 
GPNSINSLPP GVVEGSEDTI VVALYDYEAI HREDLSFQKG DQMVVLEESG EWWKARSLAT 
       130        140        150        160        170        180 
KKEGYIPSNY VARVNSLETE EWFFKGISRK DAERHLLAPG NMLGSFMIRD SETTKGSYSL 
       190        200        210        220        230        240 
SVRDFDPQHG DTVKHYKIRT LDSGGFYISP RSTFSSLQEL VVHYKKGKDG LCQKLSVPCV 
       250        260        270        280        290        300 
SPKPQKPWEK DAWEIPRESL QMEKKLGAGQ FGEVWMATYN KHTKVAVKTM KPGSMSVEAF 
       310        320        330        340        350        360 
LAEANLMKTL QHDKLVKLHA VVSQEPIFIV TEFMAKGSLL DFLKSEEGSK QPLPKLIDFS 
       370        380        390        400        410        420 
AQISEGMAFI EQRNYIHRDL RAANILVSAS LVCKIADFGL ARIIEDNEYT AREGAKFPIK 
       430        440        450        460        470        480 
WTAPEAINFG SFTIKSDVWS FGILLMEIVT YGRIPYPGMS NPEVIRALEH GYRMPRPDNC 
       490        500        510        520    
PEELYSIMIR CWKNRPEERP TFEYIQSVLD DFYTATESQY QQQP

Isoforms

- Isoform 2 of Tyrosine-protein kinase HCK - Isoform 2 of Tyrosine-protein kinase HCK

Sequence View

        10         20         30         40         50         60 
MGGRSSCEDP GCPRGEGRVP RMGCVKSRFL REGSKASKIE PNANQKGPVY VPDPTSPKKL 
        70         80         90        100        110        120 
GPNSINSLPP GVVEGSEDTI VVALYDYEAI HREDLSFQKG DQMVVLEESG EWWKARSLAT 
       130        140        150        160        170        180 
KKEGYIPSNY VARVNSLETE EWFFKGISRK DAERHLLAPG NMLGSFMIRD SETTKGSYSL 
       190        200        210        220        230        240 
SVRDFDPQHG DTVKHYKIRT LDSGGFYISP RSTFSSLQEL VVHYKKGKDG LCQKLSVPCV 
       250        260        270        280        290        300 
SPKPQKPWEK DAWEIPRESL QMEKKLGAGQ FGEVWMATYN KHTKVAVKTM KPGSMSVEAF 
       310        320        330        340        350        360 
LAEANLMKTL QHDKLVKLHA VVSQEPIFIV TEFMAKGSLL DFLKSEEGSK QPLPKLIDFS 
       370        380        390        400        410        420 
AQISEGMAFI EQRNYIHRDL RAANILVSAS LVCKIADFGL ARIIEDNEYT AREGAKFPIK 
       430        440        450        460        470        480 
WTAPEAINFG SFTIKSDVWS FGILLMEIVT YGRIPYPGMS NPEVIRALEH GYRMPRPDNC 
       490        500        510        520    
PEELYSIMIR CWKNRPEERP TFEYIQSVLD DFYTATESQY QQQP         10         20         30         40         50         60 
MGGRSSCEDP GCPRGEGRVP RMGCVKSRFL REGSKASKIE PNANQKGPVY VPDPTSPKKL 
        70         80         90        100        110        120 
GPNSINSLPP GVVEGSEDTI VVALYDYEAI HREDLSFQKG DQMVVLEESG EWWKARSLAT 
       130        140        150        160        170        180 
KKEGYIPSNY VARVNSLETE EWFFKGISRK DAERHLLAPG NMLGSFMIRD SETTKGSYSL 
       190        200        210        220        230        240 
SVRDFDPQHG DTVKHYKIRT LDSGGFYISP RSTFSSLQEL VVHYKKGKDG LCQKLSVPCV 
       250        260        270        280        290        300 
SPKPQKPWEK DAWEIPRESL QMEKKLGAGQ FGEVWMATYN KHTKVAVKTM KPGSMSVEAF 
       310        320        330        340        350        360 
LAEANLMKTL QHDKLVKLHA VVSQEPIFIV TEFMAKGSLL DFLKSEEGSK QPLPKLIDFS 
       370        380        390        400        410        420 
AQISEGMAFI EQRNYIHRDL RAANILVSAS LVCKIADFGL ARIIEDNEYT AREGAKFPIK 
       430        440        450        460        470        480 
WTAPEAINFG SFTIKSDVWS FGILLMEIVT YGRIPYPGMS NPEVIRALEH GYRMPRPDNC 
       490        500        510        520    
PEELYSIMIR CWKNRPEERP TFEYIQSVLD DFYTATESQY QQQP



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P50545-2-unknown GGRSSC... 2 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...YQQQP 524 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...YQQQP 524 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt152690

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)