P50613: Cyclin-dependent kinase 7

General Information

Protein names	- Cyclin-dependent kinase 7 - 2.7.11.22 - 2.7.11.23 - 39 kDa protein kinase - p39 Mo15 - CDK-activating kinase 1 - Cell division protein kinase 7 - Serine/threonine-protein kinase 1 - TFIIH basal transcription factor complex kinase subunit
Gene names	CDK7
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P50613

3 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MALDVKSRAK RYEKLDFLGE GQFATVYKAR DKNTNQIVAI KKIKLGHRSE AKDGINRTAL
        70         80         90        100        110        120
REIKLLQELS HPNIIGLLDA FGHKSNISLV FDFMETDLEV IIKDNSLVLT PSHIKAYMLM
       130        140        150        160        170        180
TLQGLEYLHQ HWILHRDLKP NNLLLDENGV LKLADFGLAK SFGSPNRAYT HQVVTRWYRA
       190        200        210        220        230        240
PELLFGARMY GVGVDMWAVG CILAELLLRV PFLPGDSDLD QLTRIFETLG TPTEEQWPDM
       250        260        270        280        290        300
CSLPDYVTFK SFPGIPLHHI FSAAGDDLLD LIQGLFLFNP CARITATQAL KMKYFSNRPG
       310        320        330        340
PTPGCQLPRP NCPVETLKEQ SNPALAIKRK RTEALEQGGL PKKLIF

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P50613-2-unknown	MALDVK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P50613-2-Acetylation	ALDVKS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P50613-2-Acetylation	ALDVKS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P50613-2-Acetylation	ALDVKS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P50613-94-unknown	METDLE...	94		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000425043
P50613-94-unknown	METDLE...	94		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000422121
P50613-94-unknown	METDLE...	94		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000460832
P50613-94-unknown	METDLE...	94		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000461193

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...PDMCSL	242	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000425043
...PDMCSL	242	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000460832
...KKLIF	346		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KKLIF	346	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KKLIF	346		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)