P50747: Biotin--protein ligase

General Information

Protein names	- Biotin--protein ligase - 6.3.4.- - Biotin apo-protein ligase - Biotin--methylmalonyl-CoA-carboxytransferase] ligase - 6.3.4.9 - Biotin--propionyl-CoA-carboxylase ATP-hydrolyzing]] ligase - 6.3.4.10 - Holocarboxylase synthetase - HCS - Biotin--methylcrotonoyl-CoA-carboxylase] ligase - 6.3.4.11 - Biotin--acetyl-CoA-carboxylase] ligase - 6.3.4.15
Gene names	HLCS
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P50747

1 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEDRLHMDNG LVPQKIVSVH LQDSTLKEVK DQVSNKQAQI LEPKPEPSLE IKPEQDGMEH
        70         80         90        100        110        120
VGRDDPKALG EEPKQRRGSA SGSEPAGDSD RGGGPVEHYH LHLSSCHECL ELENSTIESV
       130        140        150        160        170        180
KFASAENIPD LPYDYSSSLE SVADETSPER EGRRVNLTGK APNILLYVGS DSQEALGRFH
       190        200        210        220        230        240
EVRSVLADCV DIDSYILYHL LEDSALRDPW TDNCLLLVIA TRESIPEDLY QKFMAYLSQG
       250        260        270        280        290        300
GKVLGLSSSF TFGGFQVTSK GALHKTVQNL VFSKADQSEV KLSVLSSGCR YQEGPVRLSP
       310        320        330        340        350        360
GRLQGHLENE DKDRMIVHVP FGTRGGEAVL CQVHLELPPS SNIVQTPEDF NLLKSSNFRR
       370        380        390        400        410        420
YEVLREILTT LGLSCDMKQV PALTPLYLLS AAEEIRDPLM QWLGKHVDSE GEIKSGQLSL
       430        440        450        460        470        480
RFVSSYVSEV EITPSCIPVV TNMEAFSSEH FNLEIYRQNL QTKQLGKVIL FAEVTPTTMR
       490        500        510        520        530        540
LLDGLMFQTP QEMGLIVIAA RQTEGKGRGG NVWLSPVGCA LSTLLISIPL RSQLGQRIPF
       550        560        570        580        590        600
VQHLMSVAVV EAVRSIPEYQ DINLRVKWPN DIYYSDLMKI GGVLVNSTLM GETFYILIGC
       610        620        630        640        650        660
GFNVTNSNPT ICINDLITEY NKQHKAELKP LRADYLIARV VTVLEKLIKE FQDKGPNSVL
       670        680        690        700        710        720
PLYYRYWVHS GQQVHLGSAE GPKVSIVGLD DSGFLQVHQE GGEVVTVHPD GNSFDMLRNL

ILPKRR

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

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Evidence Names:

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Protein Neighborhood

Domains & Features

1 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P50747-1-unknown	MEDRLH...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PKQRRG	77	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396443
...GSEPAG	86	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396370
...DSDRGG	92	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000392923
...LPKRR	726	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)