P51114: Fragile X mental retardation syndrome-related protein 1

General Information

Protein names	- Fragile X mental retardation syndrome-related protein 1 - hFXR1p
Gene names	FXR1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P51114

4 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Fragile X mental retardation syndrome-related protein 1 - Isoform 3 of Fragile X mental retardation syndrome-related protein 1

Sequence View

        10         20         30         40         50         60
MAELTVEVRG SNGAFYKGFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP PPPDIKKEIS
        70         80         90        100        110        120
EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD ATYNEIVTFE RLRPVNQNKT
       130        140        150        160        170        180
VKKNTFFKCT VDVPEDLREA CANENAHKDF KKAVGACRIF YHPETTQLMI LSASEATVKR
       190        200        210        220        230        240
VNILSDMHLR SIRTKLMLMS RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN
       250        260        270        280        290        300
IQQARKVPGV TAIELDEDTG TFRIYGESAD AVKKARGFLE FVEDFIQVPR NLVGKVIGKN
       310        320        330        340        350        360
GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL LEYHIAYLKE
       370        380        390        400        410        420
VEQLRMERLQ IDEQLRQIGS RSYSGRGRGR RGPNYTSGYG TNSELSNPSE TESERKDELS
       430        440        450        460        470        480
DWSLAGEDDR DSRHQRDSRR RPGGRGRSVS GGRGRGGPRG GKSSISSVLK DPDSNPYSLL
       490        500        510        520        530        540
DNTESDQTAD TDASESHHST NRRRRSRRRR TDEDAVLMDG MTESDTASVN ENGLVTVADY
       550        560        570        580        590        600
ISRAESQSRQ RNLPRETLAK NKKEMAKDVI EEHGPSEKAI NGPTSASGDD ISKLQRTPGE
       610        620
EKINTLKEEN TQEAAVLNGV S         10         20         30         40         50         60
MAELTVEVRG SNGAFYKGFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP PPPDIKKEIS
        70         80         90        100        110        120
EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD ATYNEIVTFE RLRPVNQNKT
       130        140        150        160        170        180
VKKNTFFKCT VDVPEDLREA CANENAHKDF KKAVGACRIF YHPETTQLMI LSASEATVKR
       190        200        210        220        230        240
VNILSDMHLR SIRTKLMLMS RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN
       250        260        270        280        290        300
IQQARKVPGV TAIELDEDTG TFRIYGESAD AVKKARGFLE FVEDFIQVPR NLVGKVIGKN
       310        320        330        340        350        360
GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL LEYHIAYLKE
       370        380        390        400        410        420
VEQLRMERLQ IDEQLRQIGS RSYSGRGRGR RGPNYTSGYG TNSELSNPSE TESERKDELS
       430        440        450        460        470        480
DWSLAGEDDR DSRHQRDSRR RPGGRGRSVS GGRGRGGPRG GKSSISSVLK DPDSNPYSLL
       490        500        510        520        530        540
DNTESDQTAD TDASESHHST NRRRRSRRRR TDEDAVLMDG MTESDTASVN ENGLVTVADY
       550        560        570        580        590        600
ISRAESQSRQ RNLPRETLAK NKKEMAKDVI EEHGPSEKAI NGPTSASGDD ISKLQRTPGE
       610        620
EKINTLKEEN TQEAAVLNGV S

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P51114-2-unknown	MAELTV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P51114-1-unknown	MAELTV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75587
P51114-2-Acetylation	AELTVE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P51114-2-Acetylation	AELTVE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P51114-2-Acetylation	AELTVE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P51114-2-Acetylation	AELTVE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110038
P51114-86-unknown	MMKGEF...	86		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75588
P51114-86-unknown	MMKGEF...	86		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt99676

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...LNGVS	621	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...LNGVS	621	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt71206

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)