P51125: Calpastatin

General Information

Protein names	- Calpastatin - Calpain inhibitor
Gene names	Cast
Organism	Mus musculus
Protease Family
Protease ID	I27.001
Chromosome location
UniProt ID	P51125

6 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Calpastatin - Isoform 3 of Calpastatin - Isoform 4 of Calpastatin - Isoform 5 of Calpastatin - Isoform 6 of Calpastatin - Isoform 7 of Calpastatin

Sequence View

        10         20         30         40         50         60
MSQPGPKPAA SPRPSRGAAA RHTQEHVNEK NIGSSSKPGE KKGSDEKKAA SLGSSQPSRP
        70         80         90        100        110        120
HVGEAATATK VTASSAATSK SPSMSTTETK AIPVNKQLEG PDQKRPREQA VKTESKKPQS
       130        140        150        160        170        180
SEQPVVHEKK SKGGPKEGSE PKNLPKHTSS TGSKHAHKEK ALSRSNEQMV SEKPSESKTK
       190        200        210        220        230        240
FQDVPSAGGE SVAGGGTVAT ALDKVVGKKK EQKPFTPASP VQSTPSKPSD KSGMDAALDD
       250        260        270        280        290        300
LIDTLGGHED TNRDDPPYTG PVVLDPMYST YLEALGIKEG TIPPEYRKLL EKNEGITQPL
       310        320        330        340        350        360
PDSPKPMGTD QAIDALSSDF TCSSPTGKQS EKEKSTGEIF KAQSAGVTRS SVPPKEKKRK
       370        380        390        400        410        420
VEEEVINDQA LQALSDSLGT RQPDPPSHVS QAEQVKEAKA KEERQEKCGE DEDTVPAEYR
       430        440        450        460        470        480
LKPAKDKDGK PLLPEPEETS KSLSESELIG ELSADFDRST YQDKPSTPAE KKSNDTSQTP
       490        500        510        520        530        540
PGETVPRASM CSIRSAPPKL ASLKGVVPED AVETLAGSLG TREADPEHEK TVEDKVKEKA
       550        560        570        580        590        600
KEEEHEKLGE KEETVPPDYR LEEVKDKDGK PLLPKESQEQ LAPLSDDFLL DALSQDFSSP
       610        620        630        640        650        660
ANISSLEFED AKLSAAISEV VSQTPAPSTH AAAPLPGTEQ KDKELDDALD ELSDSLGQRP
       670        680        690        700        710        720
PDPDENKPLD DKVKEKIKPE HSEKLGERDD TIPPEYRHLL DNDGKDKPEK PPTKKTEKPD
       730        740        750        760        770        780
QDRDPIDALS EDLDSCPSTT ETSKNTAKGK SKKTSSSKAS KDGEKTKDSS KKTEEVSKPK

AKEDARHS         10         20         30         40         50         60
MSQPGPKPAA SPRPSRGAAA RHTQEHVNEK NIGSSSKPGE KKGSDEKKAA SLGSSQPSRP
        70         80         90        100        110        120
HVGEAATATK VTASSAATSK SPSMSTTETK AIPVNKQLEG PDQKRPREQA VKTESKKPQS
       130        140        150        160        170        180
SEQPVVHEKK SKGGPKEGSE PKNLPKHTSS TGSKHAHKEK ALSRSNEQMV SEKPSESKTK
       190        200        210        220        230        240
FQDVPSAGGE SVAGGGTVAT ALDKVVGKKK EQKPFTPASP VQSTPSKPSD KSGMDAALDD
       250        260        270        280        290        300
LIDTLGGHED TNRDDPPYTG PVVLDPMYST YLEALGIKEG TIPPEYRKLL EKNEGITQPL
       310        320        330        340        350        360
PDSPKPMGTD QAIDALSSDF TCSSPTGKQS EKEKSTGEIF KAQSAGVTRS SVPPKEKKRK
       370        380        390        400        410        420
VEEEVINDQA LQALSDSLGT RQPDPPSHVS QAEQVKEAKA KEERQEKCGE DEDTVPAEYR
       430        440        450        460        470        480
LKPAKDKDGK PLLPEPEETS KSLSESELIG ELSADFDRST YQDKPSTPAE KKSNDTSQTP
       490        500        510        520        530        540
PGETVPRASM CSIRSAPPKL ASLKGVVPED AVETLAGSLG TREADPEHEK TVEDKVKEKA
       550        560        570        580        590        600
KEEEHEKLGE KEETVPPDYR LEEVKDKDGK PLLPKESQEQ LAPLSDDFLL DALSQDFSSP
       610        620        630        640        650        660
ANISSLEFED AKLSAAISEV VSQTPAPSTH AAAPLPGTEQ KDKELDDALD ELSDSLGQRP
       670        680        690        700        710        720
PDPDENKPLD DKVKEKIKPE HSEKLGERDD TIPPEYRHLL DNDGKDKPEK PPTKKTEKPD
       730        740        750        760        770        780
QDRDPIDALS EDLDSCPSTT ETSKNTAKGK SKKTSSSKAS KDGEKTKDSS KKTEEVSKPK

AKEDARHS         10         20         30         40         50         60
MSQPGPKPAA SPRPSRGAAA RHTQEHVNEK NIGSSSKPGE KKGSDEKKAA SLGSSQPSRP
        70         80         90        100        110        120
HVGEAATATK VTASSAATSK SPSMSTTETK AIPVNKQLEG PDQKRPREQA VKTESKKPQS
       130        140        150        160        170        180
SEQPVVHEKK SKGGPKEGSE PKNLPKHTSS TGSKHAHKEK ALSRSNEQMV SEKPSESKTK
       190        200        210        220        230        240
FQDVPSAGGE SVAGGGTVAT ALDKVVGKKK EQKPFTPASP VQSTPSKPSD KSGMDAALDD
       250        260        270        280        290        300
LIDTLGGHED TNRDDPPYTG PVVLDPMYST YLEALGIKEG TIPPEYRKLL EKNEGITQPL
       310        320        330        340        350        360
PDSPKPMGTD QAIDALSSDF TCSSPTGKQS EKEKSTGEIF KAQSAGVTRS SVPPKEKKRK
       370        380        390        400        410        420
VEEEVINDQA LQALSDSLGT RQPDPPSHVS QAEQVKEAKA KEERQEKCGE DEDTVPAEYR
       430        440        450        460        470        480
LKPAKDKDGK PLLPEPEETS KSLSESELIG ELSADFDRST YQDKPSTPAE KKSNDTSQTP
       490        500        510        520        530        540
PGETVPRASM CSIRSAPPKL ASLKGVVPED AVETLAGSLG TREADPEHEK TVEDKVKEKA
       550        560        570        580        590        600
KEEEHEKLGE KEETVPPDYR LEEVKDKDGK PLLPKESQEQ LAPLSDDFLL DALSQDFSSP
       610        620        630        640        650        660
ANISSLEFED AKLSAAISEV VSQTPAPSTH AAAPLPGTEQ KDKELDDALD ELSDSLGQRP
       670        680        690        700        710        720
PDPDENKPLD DKVKEKIKPE HSEKLGERDD TIPPEYRHLL DNDGKDKPEK PPTKKTEKPD
       730        740        750        760        770        780
QDRDPIDALS EDLDSCPSTT ETSKNTAKGK SKKTSSSKAS KDGEKTKDSS KKTEEVSKPK

AKEDARHS         10         20         30         40         50         60
MSQPGPKPAA SPRPSRGAAA RHTQEHVNEK NIGSSSKPGE KKGSDEKKAA SLGSSQPSRP
        70         80         90        100        110        120
HVGEAATATK VTASSAATSK SPSMSTTETK AIPVNKQLEG PDQKRPREQA VKTESKKPQS
       130        140        150        160        170        180
SEQPVVHEKK SKGGPKEGSE PKNLPKHTSS TGSKHAHKEK ALSRSNEQMV SEKPSESKTK
       190        200        210        220        230        240
FQDVPSAGGE SVAGGGTVAT ALDKVVGKKK EQKPFTPASP VQSTPSKPSD KSGMDAALDD
       250        260        270        280        290        300
LIDTLGGHED TNRDDPPYTG PVVLDPMYST YLEALGIKEG TIPPEYRKLL EKNEGITQPL
       310        320        330        340        350        360
PDSPKPMGTD QAIDALSSDF TCSSPTGKQS EKEKSTGEIF KAQSAGVTRS SVPPKEKKRK
       370        380        390        400        410        420
VEEEVINDQA LQALSDSLGT RQPDPPSHVS QAEQVKEAKA KEERQEKCGE DEDTVPAEYR
       430        440        450        460        470        480
LKPAKDKDGK PLLPEPEETS KSLSESELIG ELSADFDRST YQDKPSTPAE KKSNDTSQTP
       490        500        510        520        530        540
PGETVPRASM CSIRSAPPKL ASLKGVVPED AVETLAGSLG TREADPEHEK TVEDKVKEKA
       550        560        570        580        590        600
KEEEHEKLGE KEETVPPDYR LEEVKDKDGK PLLPKESQEQ LAPLSDDFLL DALSQDFSSP
       610        620        630        640        650        660
ANISSLEFED AKLSAAISEV VSQTPAPSTH AAAPLPGTEQ KDKELDDALD ELSDSLGQRP
       670        680        690        700        710        720
PDPDENKPLD DKVKEKIKPE HSEKLGERDD TIPPEYRHLL DNDGKDKPEK PPTKKTEKPD
       730        740        750        760        770        780
QDRDPIDALS EDLDSCPSTT ETSKNTAKGK SKKTSSSKAS KDGEKTKDSS KKTEEVSKPK

AKEDARHS         10         20         30         40         50         60
MSQPGPKPAA SPRPSRGAAA RHTQEHVNEK NIGSSSKPGE KKGSDEKKAA SLGSSQPSRP
        70         80         90        100        110        120
HVGEAATATK VTASSAATSK SPSMSTTETK AIPVNKQLEG PDQKRPREQA VKTESKKPQS
       130        140        150        160        170        180
SEQPVVHEKK SKGGPKEGSE PKNLPKHTSS TGSKHAHKEK ALSRSNEQMV SEKPSESKTK
       190        200        210        220        230        240
FQDVPSAGGE SVAGGGTVAT ALDKVVGKKK EQKPFTPASP VQSTPSKPSD KSGMDAALDD
       250        260        270        280        290        300
LIDTLGGHED TNRDDPPYTG PVVLDPMYST YLEALGIKEG TIPPEYRKLL EKNEGITQPL
       310        320        330        340        350        360
PDSPKPMGTD QAIDALSSDF TCSSPTGKQS EKEKSTGEIF KAQSAGVTRS SVPPKEKKRK
       370        380        390        400        410        420
VEEEVINDQA LQALSDSLGT RQPDPPSHVS QAEQVKEAKA KEERQEKCGE DEDTVPAEYR
       430        440        450        460        470        480
LKPAKDKDGK PLLPEPEETS KSLSESELIG ELSADFDRST YQDKPSTPAE KKSNDTSQTP
       490        500        510        520        530        540
PGETVPRASM CSIRSAPPKL ASLKGVVPED AVETLAGSLG TREADPEHEK TVEDKVKEKA
       550        560        570        580        590        600
KEEEHEKLGE KEETVPPDYR LEEVKDKDGK PLLPKESQEQ LAPLSDDFLL DALSQDFSSP
       610        620        630        640        650        660
ANISSLEFED AKLSAAISEV VSQTPAPSTH AAAPLPGTEQ KDKELDDALD ELSDSLGQRP
       670        680        690        700        710        720
PDPDENKPLD DKVKEKIKPE HSEKLGERDD TIPPEYRHLL DNDGKDKPEK PPTKKTEKPD
       730        740        750        760        770        780
QDRDPIDALS EDLDSCPSTT ETSKNTAKGK SKKTSSSKAS KDGEKTKDSS KKTEEVSKPK

AKEDARHS         10         20         30         40         50         60
MSQPGPKPAA SPRPSRGAAA RHTQEHVNEK NIGSSSKPGE KKGSDEKKAA SLGSSQPSRP
        70         80         90        100        110        120
HVGEAATATK VTASSAATSK SPSMSTTETK AIPVNKQLEG PDQKRPREQA VKTESKKPQS
       130        140        150        160        170        180
SEQPVVHEKK SKGGPKEGSE PKNLPKHTSS TGSKHAHKEK ALSRSNEQMV SEKPSESKTK
       190        200        210        220        230        240
FQDVPSAGGE SVAGGGTVAT ALDKVVGKKK EQKPFTPASP VQSTPSKPSD KSGMDAALDD
       250        260        270        280        290        300
LIDTLGGHED TNRDDPPYTG PVVLDPMYST YLEALGIKEG TIPPEYRKLL EKNEGITQPL
       310        320        330        340        350        360
PDSPKPMGTD QAIDALSSDF TCSSPTGKQS EKEKSTGEIF KAQSAGVTRS SVPPKEKKRK
       370        380        390        400        410        420
VEEEVINDQA LQALSDSLGT RQPDPPSHVS QAEQVKEAKA KEERQEKCGE DEDTVPAEYR
       430        440        450        460        470        480
LKPAKDKDGK PLLPEPEETS KSLSESELIG ELSADFDRST YQDKPSTPAE KKSNDTSQTP
       490        500        510        520        530        540
PGETVPRASM CSIRSAPPKL ASLKGVVPED AVETLAGSLG TREADPEHEK TVEDKVKEKA
       550        560        570        580        590        600
KEEEHEKLGE KEETVPPDYR LEEVKDKDGK PLLPKESQEQ LAPLSDDFLL DALSQDFSSP
       610        620        630        640        650        660
ANISSLEFED AKLSAAISEV VSQTPAPSTH AAAPLPGTEQ KDKELDDALD ELSDSLGQRP
       670        680        690        700        710        720
PDPDENKPLD DKVKEKIKPE HSEKLGERDD TIPPEYRHLL DNDGKDKPEK PPTKKTEKPD
       730        740        750        760        770        780
QDRDPIDALS EDLDSCPSTT ETSKNTAKGK SKKTSSSKAS KDGEKTKDSS KKTEEVSKPK

AKEDARHS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P51125-1-unknown	MSQPGP...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P51125-1-unknown	MSQPGP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77476
P51125-1-unknown	MSQPGP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77477
P51125-71-unknown	VTASSA...	71	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
P51125-71-unknown	VTASSA...	71	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196500
P51125-71-unknown	VTASSA...	71	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196501
P51125-71-unknown	VTASSA...	71	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196502
P51125-84-unknown	MSTTET...	84	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77481
P51125-84-unknown	MSTTET...	84	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt105300
P51125-365-unknown	VINDQA...	365	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30031
P51125-365-unknown	VINDQA...	365	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149394
P51125-365-unknown	VINDQA...	365	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150265
P51125-365-unknown	VINDQA...	365	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150866
P51125-365-unknown	VINDQA...	365	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150933
P51125-449-unknown	IGELSA...	449	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30036
P51125-449-unknown	IGELSA...	449	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141932
P51125-449-unknown	IGELSA...	449	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142746
P51125-449-unknown	IGELSA...	449	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151325
P51125-449-unknown	IGELSA...	449	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152013
P51125-449-unknown	IGELSA...	449	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152471
P51125-449-unknown	IGELSA...	449	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152542
P51125-512-unknown	VETLAG...	512	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30043
P51125-512-unknown	VETLAG...	512	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144946
P51125-512-unknown	VETLAG...	512	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145530
P51125-512-unknown	VETLAG...	512	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152456
P51125-512-unknown	VETLAG...	512	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152964
P51125-512-unknown	VETLAG...	512	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153336
P51125-512-unknown	VETLAG...	512	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153383

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KVEEEV	364	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30031
...KVEEEV	364	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132779
...KVEEEV	364	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133658
...KVEEEV	364	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134268
...KVEEEV	364	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134335
...SESELI	448	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30036
...SESELI	448	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125112
...SESELI	448	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125950
...SESELI	448	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134727
...SESELI	448	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135422
...SESELI	448	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135882
...SESELI	448	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135954
...VPEDAV	511	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30043
...VPEDAV	511	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128222
...VPEDAV	511	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128828
...VPEDAV	511	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135867
...VPEDAV	511	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136390
...VPEDAV	511	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136760
...VPEDAV	511	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136808
...DARHS	788	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DARHS	788	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73097
...DARHS	788	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73096
...DARHS	788	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73099
...DARHS	788	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73095
...DARHS	788	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73094
...DARHS	788	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73098

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Evidence name
CATE_MOUSE	364	EEEV.\|.VIND	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> ICAL_MOUSE @364
CATE_MOUSE	448	SELI.\|.IGEL	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> ICAL_MOUSE @448
CATE_MOUSE	511	EDAV.\|.VETL	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> ICAL_MOUSE @511

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)