P51170: Amiloride-sensitive sodium channel subunit gamma
| Protein names | - Amiloride-sensitive sodium channel subunit gamma - Epithelial Na(+) channel subunit gamma - ENaCG - Gamma-ENaC - Gamma-NaCH - Nonvoltage-gated sodium channel 1 subunit gamma - SCNEG |
|---|---|
| Gene names | SCNN1G |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | P51170 |
3
N-termini
3
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MAPGEKIKAK IKKNLPVTGP QAPTIKELMR WYCLNTNTHG CRRIVVSRGR LRRLLWIGFT
70 80 90 100 110 120
LTAVALILWQ CALLVFSFYT VSVSIKVHFR KLDFPAVTIC NINPYKYSTV RHLLADLEQE
130 140 150 160 170 180
TREALKSLYG FPESRKRREA ESWNSVSEGK QPRFSHRIPL LIFDQDEKGK ARDFFTGRKR
190 200 210 220 230 240
KVGGSIIHKA SNVMHIESKQ VVGFQLCSND TSDCATYTFS SGINAIQEWY KLHYMNIMAQ
250 260 270 280 290 300
VPLEKKINMS YSAEELLVTC FFDGVSCDAR NFTLFHHPMH GNCYTFNNRE NETILSTSMG
310 320 330 340 350 360
GSEYGLQVIL YINEEEYNPF LVSSTGAKVI IHRQDEYPFV EDVGTEIETA MVTSIGMHLT
370 380 390 400 410 420
ESFKLSEPYS QCTEDGSDVP IRNIYNAAYS LQICLHSCFQ TKMVEKCGCA QYSQPLPPAA
430 440 450 460 470 480
NYCNYQQHPN WMYCYYQLHR AFVQEELGCQ SVCKEACSFK EWTLTTSLAQ WPSVVSEKWL
490 500 510 520 530 540
LPVLTWDQGR QVNKKLNKTD LAKLLIFYKD LNQRSIMESP ANSIEMLLSN FGGQLGLWMS
550 560 570 580 590 600
CSVVCVIEII EVFFIDFFSI IARRQWQKAK EWWAWKQAPP CPEAPRSPQG QDNPALDIDD
610 620 630 640
DLPTFNSALH LPPALGTQVP GTPPPKYNTL RLERAFSNQL TDTQMLDEL
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
3 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| P51170-1-unknown | MAPGEK... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P51170-191-unknown | SNVMHI... | 191 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC8348 | |||
| P51170-194-unknown | MHIESK... | 194 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9455 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...IIHKAS | 190 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC8348 | |||
| ...KASNVM | 193 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9455 | |||
| ...MLDEL | 649 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| CELA1_HUMAN | 190 | HKAS.|.SNVM | inferred from experiment | unknown | MEROPS | Merops CELA1_HUMAN -> SCNNG_HUMAN @190 | ||
| ELNE_HUMAN | 193 | SNVM.|.MHIE | inferred from experiment | unknown | MEROPS | Kleyman TR | Passero CJ et al.:Plasmin activates epithelial Na... (S01.131) | 18981180, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|