TopFIND 4.0

P51172: Amiloride-sensitive sodium channel subunit delta

General Information

Protein names
- Amiloride-sensitive sodium channel subunit delta
- Delta-NaCH
- Epithelial Na(+) channel subunit delta
- Delta-ENaC
- ENaCD
- Nonvoltage-gated sodium channel 1 subunit delta
- SCNED
Gene names SCNN1D
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P51172

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MRAVLSQKTT PLPRYLWPGH LSGPRRLTWS WCSDHRTPTC RELGSPHPTP CTGPARGWPR 
        70         80         90        100        110        120 
RGGGPCGFTS AGHVLCGYPL CLLSGPIQGC GTGLGDSSMA FLSRTSPVAA ASFQSRQEAR 
       130        140        150        160        170        180 
GSILLQSCQL PPQWLSTEAW TGEWKQPHGG ALTSRSPGPV APQRPCHLKG WQHRPTQHNA 
       190        200        210        220        230        240 
ACKQGQAAAQ TPPRPGPPSA PPPPPKEGHQ EGLVELPASF RELLTFFCTN ATIHGAIRLV 
       250        260        270        280        290        300 
CSRGNRLKTT SWGLLSLGAL VALCWQLGLL FERHWHRPVL MAVSVHSERK LLPLVTLCDG 
       310        320        330        340        350        360 
NPRRPSPVLR HLELLDEFAR ENIDSLYNVN LSKGRAALSA TVPRHEPPFH LDREIRLQRL 
       370        380        390        400        410        420 
SHSGSRVRVG FRLCNSTGGD CFYRGYTSGV AAVQDWYHFH YVDILALLPA AWEDSHGSQD 
       430        440        450        460        470        480 
GHFVLSCSYD GLDCQARQFR TFHHPTYGSC YTVDGVWTAQ RPGITHGVGL VLRVEQQPHL 
       490        500        510        520        530        540 
PLLSTLAGIR VMVHGRNHTP FLGHHSFSVR PGTEATISIR EDEVHRLGSP YGHCTAGGEG 
       550        560        570        580        590        600 
VEVELLHNTS YTRQACLVSC FQQLMVETCS CGYYLHPLPA GAEYCSSARH PAWGHCFYRL 
       610        620        630        640        650        660 
YQDLETHRLP CTSRCPRPCR ESAFKLSTGT SRWPSAKSAG WTLATLGEQG LPHQSHRQRS 
       670        680        690        700        710        720 
SLAKINIVYQ ELNYRSVEEA PVYSVPQLLS AMGSLCSLWF GASVLSLLEL LELLLDASAL 
       730        740        750        760        770        780 
TLVLGGRRLR RAWFSWPRAS PASGASSIKP EASQMPPPAG GTSDDPEPSG PHLPRVMLPG 
       790        800    
VLAGVSAEES WAGPQPLETL DT

Isoforms

- Isoform 2 of Amiloride-sensitive sodium channel subunit delta - Isoform 1 of Amiloride-sensitive sodium channel subunit delta

Sequence View

        10         20         30         40         50         60 
MRAVLSQKTT PLPRYLWPGH LSGPRRLTWS WCSDHRTPTC RELGSPHPTP CTGPARGWPR 
        70         80         90        100        110        120 
RGGGPCGFTS AGHVLCGYPL CLLSGPIQGC GTGLGDSSMA FLSRTSPVAA ASFQSRQEAR 
       130        140        150        160        170        180 
GSILLQSCQL PPQWLSTEAW TGEWKQPHGG ALTSRSPGPV APQRPCHLKG WQHRPTQHNA 
       190        200        210        220        230        240 
ACKQGQAAAQ TPPRPGPPSA PPPPPKEGHQ EGLVELPASF RELLTFFCTN ATIHGAIRLV 
       250        260        270        280        290        300 
CSRGNRLKTT SWGLLSLGAL VALCWQLGLL FERHWHRPVL MAVSVHSERK LLPLVTLCDG 
       310        320        330        340        350        360 
NPRRPSPVLR HLELLDEFAR ENIDSLYNVN LSKGRAALSA TVPRHEPPFH LDREIRLQRL 
       370        380        390        400        410        420 
SHSGSRVRVG FRLCNSTGGD CFYRGYTSGV AAVQDWYHFH YVDILALLPA AWEDSHGSQD 
       430        440        450        460        470        480 
GHFVLSCSYD GLDCQARQFR TFHHPTYGSC YTVDGVWTAQ RPGITHGVGL VLRVEQQPHL 
       490        500        510        520        530        540 
PLLSTLAGIR VMVHGRNHTP FLGHHSFSVR PGTEATISIR EDEVHRLGSP YGHCTAGGEG 
       550        560        570        580        590        600 
VEVELLHNTS YTRQACLVSC FQQLMVETCS CGYYLHPLPA GAEYCSSARH PAWGHCFYRL 
       610        620        630        640        650        660 
YQDLETHRLP CTSRCPRPCR ESAFKLSTGT SRWPSAKSAG WTLATLGEQG LPHQSHRQRS 
       670        680        690        700        710        720 
SLAKINIVYQ ELNYRSVEEA PVYSVPQLLS AMGSLCSLWF GASVLSLLEL LELLLDASAL 
       730        740        750        760        770        780 
TLVLGGRRLR RAWFSWPRAS PASGASSIKP EASQMPPPAG GTSDDPEPSG PHLPRVMLPG 
       790        800    
VLAGVSAEES WAGPQPLETL DT         10         20         30         40         50         60 
MRAVLSQKTT PLPRYLWPGH LSGPRRLTWS WCSDHRTPTC RELGSPHPTP CTGPARGWPR 
        70         80         90        100        110        120 
RGGGPCGFTS AGHVLCGYPL CLLSGPIQGC GTGLGDSSMA FLSRTSPVAA ASFQSRQEAR 
       130        140        150        160        170        180 
GSILLQSCQL PPQWLSTEAW TGEWKQPHGG ALTSRSPGPV APQRPCHLKG WQHRPTQHNA 
       190        200        210        220        230        240 
ACKQGQAAAQ TPPRPGPPSA PPPPPKEGHQ EGLVELPASF RELLTFFCTN ATIHGAIRLV 
       250        260        270        280        290        300 
CSRGNRLKTT SWGLLSLGAL VALCWQLGLL FERHWHRPVL MAVSVHSERK LLPLVTLCDG 
       310        320        330        340        350        360 
NPRRPSPVLR HLELLDEFAR ENIDSLYNVN LSKGRAALSA TVPRHEPPFH LDREIRLQRL 
       370        380        390        400        410        420 
SHSGSRVRVG FRLCNSTGGD CFYRGYTSGV AAVQDWYHFH YVDILALLPA AWEDSHGSQD 
       430        440        450        460        470        480 
GHFVLSCSYD GLDCQARQFR TFHHPTYGSC YTVDGVWTAQ RPGITHGVGL VLRVEQQPHL 
       490        500        510        520        530        540 
PLLSTLAGIR VMVHGRNHTP FLGHHSFSVR PGTEATISIR EDEVHRLGSP YGHCTAGGEG 
       550        560        570        580        590        600 
VEVELLHNTS YTRQACLVSC FQQLMVETCS CGYYLHPLPA GAEYCSSARH PAWGHCFYRL 
       610        620        630        640        650        660 
YQDLETHRLP CTSRCPRPCR ESAFKLSTGT SRWPSAKSAG WTLATLGEQG LPHQSHRQRS 
       670        680        690        700        710        720 
SLAKINIVYQ ELNYRSVEEA PVYSVPQLLS AMGSLCSLWF GASVLSLLEL LELLLDASAL 
       730        740        750        760        770        780 
TLVLGGRRLR RAWFSWPRAS PASGASSIKP EASQMPPPAG GTSDDPEPSG PHLPRVMLPG 
       790        800    
VLAGVSAEES WAGPQPLETL DT



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Evidence Codes:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P51172-1-unknown MRAVLS... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...PSAKSA 638 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...PSAKSA 638 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt84712

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)