P51790: H(+)/Cl(-) exchange transporter 3

General Information

Protein names	- H(+)/Cl(-) exchange transporter 3 - Chloride channel protein 3 - ClC-3 - Chloride transporter ClC-3
Gene names	CLCN3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P51790

1 N-termini

5 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of H(+)/Cl(-) exchange transporter 3 - Isoform 3 of H(+)/Cl(-) exchange transporter 3 - Isoform 4 of H(+)/Cl(-) exchange transporter 3

Sequence View

        10         20         30         40         50         60
MESEQLFHRG YYRNSYNSIT SASSDEELLD GAGVIMDFQT SEDDNLLDGD TAVGTHYTMT
        70         80         90        100        110        120
NGGSINSSTH LLDLLDEPIP GVGTYDDFHT IDWVREKCKD RERHRRINSK KKESAWEMTK
       130        140        150        160        170        180
SLYDAWSGWL VVTLTGLASG ALAGLIDIAA DWMTDLKEGI CLSALWYNHE QCCWGSNETT
       190        200        210        220        230        240
FEERDKCPQW KTWAELIIGQ AEGPGSYIMN YIMYIFWALS FAFLAVSLVK VFAPYACGSG
       250        260        270        280        290        300
IPEIKTILSG FIIRGYLGKW TLMIKTITLV LAVASGLSLG KEGPLVHVAC CCGNIFSYLF
       310        320        330        340        350        360
PKYSTNEAKK REVLSAASAA GVSVAFGAPI GGVLFSLEEV SYYFPLKTLW RSFFAALVAA
       370        380        390        400        410        420
FVLRSINPFG NSRLVLFYVE YHTPWYLFEL FPFILLGVFG GLWGAFFIRA NIAWCRRRKS
       430        440        450        460        470        480
TKFGKYPVLE VIIVAAITAV IAFPNPYTRL NTSELIKELF TDCGPLESSS LCDYRNDMNA
       490        500        510        520        530        540
SKIVDDIPDR PAGIGVYSAI WQLCLALIFK IIMTVFTFGI KVPSGLFIPS MAIGAIAGRI
       550        560        570        580        590        600
VGIAVEQLAY YHHDWFIFKE WCEVGADCIT PGLYAMVGAA ACLGGVTRMT VSLVVIVFEL
       610        620        630        640        650        660
TGGLEYIVPL MAAVMTSKWV GDAFGREGIY EAHIRLNGYP FLDAKEEFTH TTLAADVMRP
       670        680        690        700        710        720
RRNDPPLAVL TQDNMTVDDI ENMINETSYN GFPVIMSKES QRLVGFALRR DLTIAIESAR
       730        740        750        760        770        780
KKQEGIVGSS RVCFAQHTPS LPAESPRPLK LRSILDMSPF TVTDHTPMEI VVDIFRKLGL
       790        800        810
RQCLVTHNGR LLGIITKKDI LRHMAQTANQ DPASIMFN         10         20         30         40         50         60
MESEQLFHRG YYRNSYNSIT SASSDEELLD GAGVIMDFQT SEDDNLLDGD TAVGTHYTMT
        70         80         90        100        110        120
NGGSINSSTH LLDLLDEPIP GVGTYDDFHT IDWVREKCKD RERHRRINSK KKESAWEMTK
       130        140        150        160        170        180
SLYDAWSGWL VVTLTGLASG ALAGLIDIAA DWMTDLKEGI CLSALWYNHE QCCWGSNETT
       190        200        210        220        230        240
FEERDKCPQW KTWAELIIGQ AEGPGSYIMN YIMYIFWALS FAFLAVSLVK VFAPYACGSG
       250        260        270        280        290        300
IPEIKTILSG FIIRGYLGKW TLMIKTITLV LAVASGLSLG KEGPLVHVAC CCGNIFSYLF
       310        320        330        340        350        360
PKYSTNEAKK REVLSAASAA GVSVAFGAPI GGVLFSLEEV SYYFPLKTLW RSFFAALVAA
       370        380        390        400        410        420
FVLRSINPFG NSRLVLFYVE YHTPWYLFEL FPFILLGVFG GLWGAFFIRA NIAWCRRRKS
       430        440        450        460        470        480
TKFGKYPVLE VIIVAAITAV IAFPNPYTRL NTSELIKELF TDCGPLESSS LCDYRNDMNA
       490        500        510        520        530        540
SKIVDDIPDR PAGIGVYSAI WQLCLALIFK IIMTVFTFGI KVPSGLFIPS MAIGAIAGRI
       550        560        570        580        590        600
VGIAVEQLAY YHHDWFIFKE WCEVGADCIT PGLYAMVGAA ACLGGVTRMT VSLVVIVFEL
       610        620        630        640        650        660
TGGLEYIVPL MAAVMTSKWV GDAFGREGIY EAHIRLNGYP FLDAKEEFTH TTLAADVMRP
       670        680        690        700        710        720
RRNDPPLAVL TQDNMTVDDI ENMINETSYN GFPVIMSKES QRLVGFALRR DLTIAIESAR
       730        740        750        760        770        780
KKQEGIVGSS RVCFAQHTPS LPAESPRPLK LRSILDMSPF TVTDHTPMEI VVDIFRKLGL
       790        800        810
RQCLVTHNGR LLGIITKKDI LRHMAQTANQ DPASIMFN         10         20         30         40         50         60
MESEQLFHRG YYRNSYNSIT SASSDEELLD GAGVIMDFQT SEDDNLLDGD TAVGTHYTMT
        70         80         90        100        110        120
NGGSINSSTH LLDLLDEPIP GVGTYDDFHT IDWVREKCKD RERHRRINSK KKESAWEMTK
       130        140        150        160        170        180
SLYDAWSGWL VVTLTGLASG ALAGLIDIAA DWMTDLKEGI CLSALWYNHE QCCWGSNETT
       190        200        210        220        230        240
FEERDKCPQW KTWAELIIGQ AEGPGSYIMN YIMYIFWALS FAFLAVSLVK VFAPYACGSG
       250        260        270        280        290        300
IPEIKTILSG FIIRGYLGKW TLMIKTITLV LAVASGLSLG KEGPLVHVAC CCGNIFSYLF
       310        320        330        340        350        360
PKYSTNEAKK REVLSAASAA GVSVAFGAPI GGVLFSLEEV SYYFPLKTLW RSFFAALVAA
       370        380        390        400        410        420
FVLRSINPFG NSRLVLFYVE YHTPWYLFEL FPFILLGVFG GLWGAFFIRA NIAWCRRRKS
       430        440        450        460        470        480
TKFGKYPVLE VIIVAAITAV IAFPNPYTRL NTSELIKELF TDCGPLESSS LCDYRNDMNA
       490        500        510        520        530        540
SKIVDDIPDR PAGIGVYSAI WQLCLALIFK IIMTVFTFGI KVPSGLFIPS MAIGAIAGRI
       550        560        570        580        590        600
VGIAVEQLAY YHHDWFIFKE WCEVGADCIT PGLYAMVGAA ACLGGVTRMT VSLVVIVFEL
       610        620        630        640        650        660
TGGLEYIVPL MAAVMTSKWV GDAFGREGIY EAHIRLNGYP FLDAKEEFTH TTLAADVMRP
       670        680        690        700        710        720
RRNDPPLAVL TQDNMTVDDI ENMINETSYN GFPVIMSKES QRLVGFALRR DLTIAIESAR
       730        740        750        760        770        780
KKQEGIVGSS RVCFAQHTPS LPAESPRPLK LRSILDMSPF TVTDHTPMEI VVDIFRKLGL
       790        800        810
RQCLVTHNGR LLGIITKKDI LRHMAQTANQ DPASIMFN

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

1 N-termini - 5 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P51790-1-unknown	MESEQL...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P51790-1-unknown	MESEQL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70924
P51790-1-unknown	MESEQL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70925

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LTGLAS	138	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000425823
...LTGLAS	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154820
...LTGLAS	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154821
...LTGLAS	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154822
...HEQCCW	173	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000425160
...HEQCCW	173	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155306
...HEQCCW	173	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155307
...HEQCCW	173	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155308
...VTRMTV	590	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000422678
...PLKLRS	752	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000425323
...SIMFN	818	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SIMFN	818	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66543
...SIMFN	818	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66544

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)