P51878: Caspase-5

General Information

Protein names	- Caspase-5 - CASP-5 - 3.4.22.58 - ICE(rel)-III - Protease ICH-3 - Protease TY - Caspase-5 subunit p20 - Caspase-5 subunit p10
Gene names	CASP5
Organism	Homo sapiens
Protease Family	C14.008
Protease ID	C14.008
Chromosome location
UniProt ID	P51878

3 N-termini

2 C-termini

0 Cleavages

1 Substrates

Sequence

Isoforms

- Isoform 2 of Caspase-5 - Isoform 3 of Caspase-5 - Isoform 4 of Caspase-5 - Isoform 5 of Caspase-5 - Isoform 6 of Caspase-5

Sequence View

        10         20         30         40         50         60
MAEDSGKKKR RKNFEAMFKG ILQSGLDNFV INHMLKNNVA GQTSIQTLVP NTDQKSTSVK
        70         80         90        100        110        120
KDNHKKKTVK MLEYLGKDVL HGVFNYLAKH DVLTLKEEEK KKYYDTKIED KALILVDSLR
       130        140        150        160        170        180
KNRVAHQMFT QTLLNMDQKI TSVKPLLQIE AGPPESAEST NILKLCPREE FLRLCKKNHD
       190        200        210        220        230        240
EIYPIKKRED RRRLALIICN TKFDHLPARN GAHYDIVGMK RLLQGLGYTV VDEKNLTARD
       250        260        270        280        290        300
MESVLRAFAA RPEHKSSDST FLVLMSHGIL EGICGTAHKK KKPDVLLYDT IFQIFNNRNC
       310        320        330        340        350        360
LSLKDKPKVI IVQACRGEKH GELWVRDSPA SLALISSQSS ENLEADSVCK IHEEKDFIAF
       370        380        390        400        410        420
CSSTPHNVSW RDRTRGSIFI TELITCFQKY SCCCHLMEIF RKVQKSFEVP QAKAQMPTIE
       430
RATLTRDFYL FPGN         10         20         30         40         50         60
MAEDSGKKKR RKNFEAMFKG ILQSGLDNFV INHMLKNNVA GQTSIQTLVP NTDQKSTSVK
        70         80         90        100        110        120
KDNHKKKTVK MLEYLGKDVL HGVFNYLAKH DVLTLKEEEK KKYYDTKIED KALILVDSLR
       130        140        150        160        170        180
KNRVAHQMFT QTLLNMDQKI TSVKPLLQIE AGPPESAEST NILKLCPREE FLRLCKKNHD
       190        200        210        220        230        240
EIYPIKKRED RRRLALIICN TKFDHLPARN GAHYDIVGMK RLLQGLGYTV VDEKNLTARD
       250        260        270        280        290        300
MESVLRAFAA RPEHKSSDST FLVLMSHGIL EGICGTAHKK KKPDVLLYDT IFQIFNNRNC
       310        320        330        340        350        360
LSLKDKPKVI IVQACRGEKH GELWVRDSPA SLALISSQSS ENLEADSVCK IHEEKDFIAF
       370        380        390        400        410        420
CSSTPHNVSW RDRTRGSIFI TELITCFQKY SCCCHLMEIF RKVQKSFEVP QAKAQMPTIE
       430
RATLTRDFYL FPGN         10         20         30         40         50         60
MAEDSGKKKR RKNFEAMFKG ILQSGLDNFV INHMLKNNVA GQTSIQTLVP NTDQKSTSVK
        70         80         90        100        110        120
KDNHKKKTVK MLEYLGKDVL HGVFNYLAKH DVLTLKEEEK KKYYDTKIED KALILVDSLR
       130        140        150        160        170        180
KNRVAHQMFT QTLLNMDQKI TSVKPLLQIE AGPPESAEST NILKLCPREE FLRLCKKNHD
       190        200        210        220        230        240
EIYPIKKRED RRRLALIICN TKFDHLPARN GAHYDIVGMK RLLQGLGYTV VDEKNLTARD
       250        260        270        280        290        300
MESVLRAFAA RPEHKSSDST FLVLMSHGIL EGICGTAHKK KKPDVLLYDT IFQIFNNRNC
       310        320        330        340        350        360
LSLKDKPKVI IVQACRGEKH GELWVRDSPA SLALISSQSS ENLEADSVCK IHEEKDFIAF
       370        380        390        400        410        420
CSSTPHNVSW RDRTRGSIFI TELITCFQKY SCCCHLMEIF RKVQKSFEVP QAKAQMPTIE
       430
RATLTRDFYL FPGN         10         20         30         40         50         60
MAEDSGKKKR RKNFEAMFKG ILQSGLDNFV INHMLKNNVA GQTSIQTLVP NTDQKSTSVK
        70         80         90        100        110        120
KDNHKKKTVK MLEYLGKDVL HGVFNYLAKH DVLTLKEEEK KKYYDTKIED KALILVDSLR
       130        140        150        160        170        180
KNRVAHQMFT QTLLNMDQKI TSVKPLLQIE AGPPESAEST NILKLCPREE FLRLCKKNHD
       190        200        210        220        230        240
EIYPIKKRED RRRLALIICN TKFDHLPARN GAHYDIVGMK RLLQGLGYTV VDEKNLTARD
       250        260        270        280        290        300
MESVLRAFAA RPEHKSSDST FLVLMSHGIL EGICGTAHKK KKPDVLLYDT IFQIFNNRNC
       310        320        330        340        350        360
LSLKDKPKVI IVQACRGEKH GELWVRDSPA SLALISSQSS ENLEADSVCK IHEEKDFIAF
       370        380        390        400        410        420
CSSTPHNVSW RDRTRGSIFI TELITCFQKY SCCCHLMEIF RKVQKSFEVP QAKAQMPTIE
       430
RATLTRDFYL FPGN         10         20         30         40         50         60
MAEDSGKKKR RKNFEAMFKG ILQSGLDNFV INHMLKNNVA GQTSIQTLVP NTDQKSTSVK
        70         80         90        100        110        120
KDNHKKKTVK MLEYLGKDVL HGVFNYLAKH DVLTLKEEEK KKYYDTKIED KALILVDSLR
       130        140        150        160        170        180
KNRVAHQMFT QTLLNMDQKI TSVKPLLQIE AGPPESAEST NILKLCPREE FLRLCKKNHD
       190        200        210        220        230        240
EIYPIKKRED RRRLALIICN TKFDHLPARN GAHYDIVGMK RLLQGLGYTV VDEKNLTARD
       250        260        270        280        290        300
MESVLRAFAA RPEHKSSDST FLVLMSHGIL EGICGTAHKK KKPDVLLYDT IFQIFNNRNC
       310        320        330        340        350        360
LSLKDKPKVI IVQACRGEKH GELWVRDSPA SLALISSQSS ENLEADSVCK IHEEKDFIAF
       370        380        390        400        410        420
CSSTPHNVSW RDRTRGSIFI TELITCFQKY SCCCHLMEIF RKVQKSFEVP QAKAQMPTIE
       430
RATLTRDFYL FPGN

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 1 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P51878-71-unknown	MLEYLG...	71	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt69340
P51878-71-unknown	MLEYLG...	71	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt108130
P51878-71-unknown	MLEYLG...	71	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt108131
P51878-71-unknown	MLEYLG...	71	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt108129
P51878-137-unknown	DQKITS...	137	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P51878-137-unknown	DQKITS...	137	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115935
P51878-137-unknown	DQKITS...	137	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115937
P51878-137-unknown	DQKITS...	137	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115936
P51878-347-unknown	SVCKIH...	347	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P51878-347-unknown	SVCKIH...	347	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116171
P51878-347-unknown	SVCKIH...	347	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116169
P51878-347-unknown	SVCKIH...	347	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116172
P51878-347-unknown	SVCKIH...	347	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116170

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LWVRDS	327	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LWVRDS	327	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92408
...LWVRDS	327	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92406
...LWVRDS	327	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92409
...LWVRDS	327	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92407
...LFPGN	434	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LFPGN	434	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64955
...LFPGN	434	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64958
...LFPGN	434	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64954
...LFPGN	434	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64957

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MAX_HUMAN	10	EVES.\|.SDEE	inferred from experiment	unknown	MEROPS	Luscher B	Krippner-Heidenreich A et al.:Targeting of the transcription ... (C14.008)	11535131,