TopFIND 4.0

P51955: Serine/threonine-protein kinase Nek2

General Information

Protein names
- Serine/threonine-protein kinase Nek2
- 2.7.11.1
- HSPK 21
- Never in mitosis A-related kinase 2
- NimA-related protein kinase 2
- NimA-like protein kinase 1
Gene names NEK2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P51955

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MPSRAEDYEV LYTIGTGSYG RCQKIRRKSD GKILVWKELD YGSMTEAEKQ MLVSEVNLLR 
        70         80         90        100        110        120 
ELKHPNIVRY YDRIIDRTNT TLYIVMEYCE GGDLASVITK GTKERQYLDE EFVLRVMTQL 
       130        140        150        160        170        180 
TLALKECHRR SDGGHTVLHR DLKPANVFLD GKQNVKLGDF GLARILNHDT SFAKTFVGTP 
       190        200        210        220        230        240 
YYMSPEQMNR MSYNEKSDIW SLGCLLYELC ALMPPFTAFS QKELAGKIRE GKFRRIPYRY 
       250        260        270        280        290        300 
SDELNEIITR MLNLKDYHRP SVEEILENPL IADLVADEQR RNLERRGRQL GEPEKSQDSS 
       310        320        330        340        350        360 
PVLSELKLKE IQLQERERAL KAREERLEQK EQELCVRERL AEDKLARAEN LLKNYSLLKE 
       370        380        390        400        410        420 
RKFLSLASNP ELLNLPSSVI KKKVHFSGES KENIMRSENS ESQLTSKSKC KDLKKRLHAA 
       430        440    
QLRAQALSDI EKNYQLKSRQ ILGMR

Isoforms

- Isoform 2 of Serine/threonine-protein kinase Nek2 - Isoform 3 of Serine/threonine-protein kinase Nek2 - Isoform 4 of Serine/threonine-protein kinase Nek2

Sequence View

        10         20         30         40         50         60 
MPSRAEDYEV LYTIGTGSYG RCQKIRRKSD GKILVWKELD YGSMTEAEKQ MLVSEVNLLR 
        70         80         90        100        110        120 
ELKHPNIVRY YDRIIDRTNT TLYIVMEYCE GGDLASVITK GTKERQYLDE EFVLRVMTQL 
       130        140        150        160        170        180 
TLALKECHRR SDGGHTVLHR DLKPANVFLD GKQNVKLGDF GLARILNHDT SFAKTFVGTP 
       190        200        210        220        230        240 
YYMSPEQMNR MSYNEKSDIW SLGCLLYELC ALMPPFTAFS QKELAGKIRE GKFRRIPYRY 
       250        260        270        280        290        300 
SDELNEIITR MLNLKDYHRP SVEEILENPL IADLVADEQR RNLERRGRQL GEPEKSQDSS 
       310        320        330        340        350        360 
PVLSELKLKE IQLQERERAL KAREERLEQK EQELCVRERL AEDKLARAEN LLKNYSLLKE 
       370        380        390        400        410        420 
RKFLSLASNP ELLNLPSSVI KKKVHFSGES KENIMRSENS ESQLTSKSKC KDLKKRLHAA 
       430        440    
QLRAQALSDI EKNYQLKSRQ ILGMR         10         20         30         40         50         60 
MPSRAEDYEV LYTIGTGSYG RCQKIRRKSD GKILVWKELD YGSMTEAEKQ MLVSEVNLLR 
        70         80         90        100        110        120 
ELKHPNIVRY YDRIIDRTNT TLYIVMEYCE GGDLASVITK GTKERQYLDE EFVLRVMTQL 
       130        140        150        160        170        180 
TLALKECHRR SDGGHTVLHR DLKPANVFLD GKQNVKLGDF GLARILNHDT SFAKTFVGTP 
       190        200        210        220        230        240 
YYMSPEQMNR MSYNEKSDIW SLGCLLYELC ALMPPFTAFS QKELAGKIRE GKFRRIPYRY 
       250        260        270        280        290        300 
SDELNEIITR MLNLKDYHRP SVEEILENPL IADLVADEQR RNLERRGRQL GEPEKSQDSS 
       310        320        330        340        350        360 
PVLSELKLKE IQLQERERAL KAREERLEQK EQELCVRERL AEDKLARAEN LLKNYSLLKE 
       370        380        390        400        410        420 
RKFLSLASNP ELLNLPSSVI KKKVHFSGES KENIMRSENS ESQLTSKSKC KDLKKRLHAA 
       430        440    
QLRAQALSDI EKNYQLKSRQ ILGMR         10         20         30         40         50         60 
MPSRAEDYEV LYTIGTGSYG RCQKIRRKSD GKILVWKELD YGSMTEAEKQ MLVSEVNLLR 
        70         80         90        100        110        120 
ELKHPNIVRY YDRIIDRTNT TLYIVMEYCE GGDLASVITK GTKERQYLDE EFVLRVMTQL 
       130        140        150        160        170        180 
TLALKECHRR SDGGHTVLHR DLKPANVFLD GKQNVKLGDF GLARILNHDT SFAKTFVGTP 
       190        200        210        220        230        240 
YYMSPEQMNR MSYNEKSDIW SLGCLLYELC ALMPPFTAFS QKELAGKIRE GKFRRIPYRY 
       250        260        270        280        290        300 
SDELNEIITR MLNLKDYHRP SVEEILENPL IADLVADEQR RNLERRGRQL GEPEKSQDSS 
       310        320        330        340        350        360 
PVLSELKLKE IQLQERERAL KAREERLEQK EQELCVRERL AEDKLARAEN LLKNYSLLKE 
       370        380        390        400        410        420 
RKFLSLASNP ELLNLPSSVI KKKVHFSGES KENIMRSENS ESQLTSKSKC KDLKKRLHAA 
       430        440    
QLRAQALSDI EKNYQLKSRQ ILGMR



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...ILGMR 445 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...ILGMR 445 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt78207

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)