P53350: Serine/threonine-protein kinase PLK1

General Information

Protein names	- Serine/threonine-protein kinase PLK1 - 2.7.11.21 {ECO:0000269\|PubMed:11202906, ECO:0000269\|PubMed:12207013, ECO:0000269\|PubMed:21880710} - Polo-like kinase 1 - PLK-1 - Serine/threonine-protein kinase 13 - STPK13
Gene names	PLK1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P53350

3 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSAAVTAGKL ARAPADPGKA GVPGVAAPGA PAAAPPAKEI PEVLVDPRSR RRYVRGRFLG
        70         80         90        100        110        120
KGGFAKCFEI SDADTKEVFA GKIVPKSLLL KPHQREKMSM EISIHRSLAH QHVVGFHGFF
       130        140        150        160        170        180
EDNDFVFVVL ELCRRRSLLE LHKRRKALTE PEARYYLRQI VLGCQYLHRN RVIHRDLKLG
       190        200        210        220        230        240
NLFLNEDLEV KIGDFGLATK VEYDGERKKT LCGTPNYIAP EVLSKKGHSF EVDVWSIGCI
       250        260        270        280        290        300
MYTLLVGKPP FETSCLKETY LRIKKNEYSI PKHINPVAAS LIQKMLQTDP TARPTINELL
       310        320        330        340        350        360
NDEFFTSGYI PARLPITCLT IPPRFSIAPS SLDPSNRKPL TVLNKGLENP LPERPREKEE
       370        380        390        400        410        420
PVVRETGEVV DCHLSDMLQQ LHSVNASKPS ERGLVRQEEA EDPACIPIFW VSKWVDYSDK
       430        440        450        460        470        480
YGLGYQLCDN SVGVLFNDST RLILYNDGDS LQYIERDGTE SYLTVSSHPN SLMKKITLLK
       490        500        510        520        530        540
YFRNYMSEHL LKAGANITPR EGDELARLPY LRTWFRTRSA IILHLSNGSV QINFFQDHTK
       550        560        570        580        590        600
LILCPLMAAV TYIDEKRDFR TYRLSLLEEY GCCKELASRL RYARTMVDKL LSSRSASNRL

KAS

Isoforms

Sequence View

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Evidence Codes:

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Evidence Names:

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P53350-2-unknown	MSAAVT...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P53350-2-Acetylation	SAAVTA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P53350-2-Acetylation	SAAVTA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P53350-2-Acetylation	SAAVTA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P53350-241-unknown	MYTLLV...	241		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000459688
P53350-241-unknown	MYTLLV...	241		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000460084

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PTINEL	298	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000460084
...TVLNKG	345	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000459688
...RLKAS	603	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)