P54132: Bloom syndrome protein

General Information

Protein names	- Bloom syndrome protein - 3.6.4.12 {ECO:0000269\|PubMed:24816114, ECO:0000269\|PubMed:25901030} - DNA helicase, RecQ-like type 2 - RecQ2 - RecQ protein-like 3
Gene names	BLM
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P54132

6 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAVPQNNLQ EQLERHSART LNNKLSLSKP KFSGFTFKKK TSSDNNVSVT NVSVAKTPVL
        70         80         90        100        110        120
RNKDVNVTED FSFSEPLPNT TNQQRVKDFF KNAPAGQETQ RGGSKSLLPD FLQTPKEVVC
       130        140        150        160        170        180
TTQNTPTVKK SRDTALKKLE FSSSPDSLST INDWDDMDDF DTSETSKSFV TPPQSHFVRV
       190        200        210        220        230        240
STAQKSKKGK RNFFKAQLYT TNTVKTDLPP PSSESEQIDL TEEQKDDSEW LSSDVICIDD
       250        260        270        280        290        300
GPIAEVHINE DAQESDSLKT HLEDERDNSE KKKNLEEAEL HSTEKVPCIE FDDDDYDTDF
       310        320        330        340        350        360
VPPSPEEIIS ASSSSSKCLS TLKDLDTSDR KEDVLSTSKD LLSKPEKMSM QELNPETSTD
       370        380        390        400        410        420
CDARQISLQQ QLIHVMEHIC KLIDTIPDDK LKLLDCGNEL LQQRNIRRKL LTEVDFNKSD
       430        440        450        460        470        480
ASLLGSLWRY RPDSLDGPME GDSCPTGNSM KELNFSHLPS NSVSPGDCLL TTTLGKTGFS
       490        500        510        520        530        540
ATRKNLFERP LFNTHLQKSF VSSNWAETPR LGKKNESSYF PGNVLTSTAV KDQNKHTASI
       550        560        570        580        590        600
NDLERETQPS YDIDNFDIDD FDDDDDWEDI MHNLAASKSS TAAYQPIKEG RPIKSVSERL
       610        620        630        640        650        660
SSAKTDCLPV SSTAQNINFS ESIQNYTDKS AQNLASRNLK HERFQSLSFP HTKEMMKIFH
       670        680        690        700        710        720
KKFGLHNFRT NQLEAINAAL LGEDCFILMP TGGGKSLCYQ LPACVSPGVT VVISPLRSLI
       730        740        750        760        770        780
VDQVQKLTSL DIPATYLTGD KTDSEATNIY LQLSKKDPII KLLYVTPEKI CASNRLISTL
       790        800        810        820        830        840
ENLYERKLLA RFVIDEAHCV SQWGHDFRQD YKRMNMLRQK FPSVPVMALT ATANPRVQKD
       850        860        870        880        890        900
ILTQLKILRP QVFSMSFNRH NLKYYVLPKK PKKVAFDCLE WIRKHHPYDS GIIYCLSRRE
       910        920        930        940        950        960
CDTMADTLQR DGLAALAYHA GLSDSARDEV QQKWINQDGC QVICATIAFG MGIDKPDVRF
       970        980        990       1000       1010       1020
VIHASLPKSV EGYYQESGRA GRDGEISHCL LFYTYHDVTR LKRLIMMEKD GNHHTRETHF
      1030       1040       1050       1060       1070       1080
NNLYSMVHYC ENITECRRIQ LLAYFGENGF NPDFCKKHPD VSCDNCCKTK DYKTRDVTDD
      1090       1100       1110       1120       1130       1140
VKSIVRFVQE HSSSQGMRNI KHVGPSGRFT MNMLVDIFLG SKSAKIQSGI FGKGSAYSRH
      1150       1160       1170       1180       1190       1200
NAERLFKKLI LDKILDEDLY INANDQAIAY VMLGNKAQTV LNGNLKVDFM ETENSSSVKK
      1210       1220       1230       1240       1250       1260
QKALVAKVSQ REEMVKKCLG ELTEVCKSLG KVFGVHYFNI FNTVTLKKLA ESLSSDPEVL
      1270       1280       1290       1300       1310       1320
LQIDGVTEDK LEKYGAEVIS VLQKYSEWTS PAEDSSPGIS LSSSRGPGRS AAEELDEEIP
      1330       1340       1350       1360       1370       1380
VSSHYFASKT RNERKRKKMP ASQRSKRRKT ASSGSKAKGG SATCRKISSK TKSSSIIGSS
      1390       1400       1410
SASHTSQATS GANSKLGIMA PPKPINRPFL KPSYAFS

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P54132-1-unknown	MAAVPQ...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P54132-2-acetylation	AAVPQN...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P54132-72-	SFSEPL...	72			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P54132-72-unknown	SFSEPL...	72			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P54132-416-unknown	FNKSDA...	416		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1903
P54132-437-unknown	GPMEGD...	437		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1904

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LTEVDF	415	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1903
...PDSLDG	436	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1904
...SYAFS	1417	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	415	EVDF.\|.FNKS	inferred from experiment	unknown	MEROPS	Campisi J	Bischof O et al.:Selective cleavage of BLM, the ... (C14.003)	11154689,
CASP3_HUMAN	436	SLDG.\|.GPME	inferred from experiment	unknown	MEROPS	Jackson SP	Freire R et al.:Cleavage of the Bloom's syndrom... (C14.003)	11470874,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)