P54265: Myotonin-protein kinase
| Protein names | - Myotonin-protein kinase - MT-PK - 2.7.11.1 - DM-kinase - DMK - DMPK - Myotonic dystrophy protein kinase - MDPK |
|---|---|
| Gene names | Dmpk |
| Organism | Mus musculus |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | P54265 |
1
N-termini
1
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSAEVRLRQL QQLVLDPGFL GLEPLLDLLL GVHQELGASH LAQDKYVADF LQWVEPIAAR
70 80 90 100 110 120
LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER
130 140 150 160 170 180
DVLVKGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV
190 200 210 220 230 240
MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL QPDGMVRSLV AVGTPDYLSP
250 260 270 280 290 300
EILQAVGGGP GAGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYAKI VHYREHLSLP
310 320 330 340 350 360
LADTVVPEEA QDLIRGLLCP AEIRLGRGGA GDFQKHPFFF GLDWEGLRDS VPPFTPDFEG
370 380 390 400 410 420
ATDTCNFDVV EDRLTAMVSG GGETLSDMQE DMPLGVRLPF VGYSYCCMAF RDNQVPDPTP
430 440 450 460 470 480
MELEALQLPV SDLQGLDLQP PVSPPDQVAE EADLVAVPAP VAEAETTVTL QQLQEALEEE
490 500 510 520 530 540
VLTRQSLSRE LEAIRTANQN FSSQLQEAEV RNRDLEAHVR QLQERMEMLQ APGAAAITGV
550 560 570 580 590 600
PSPRATDPPS HLDGPPAVAV GQCPLVGPGP MHRRHLLLPA RIPRPGLSEA RCLLLFAAAL
610 620 630
AAAATLGCTG LVAYTGGLTP VWCFPGATFA P
Isoforms
- Isoform 2 of Myotonin-protein kinase - Isoform 3 of Myotonin-protein kinase - Isoform 4 of Myotonin-protein kinase - Isoform 5 of Myotonin-protein kinase - Isoform 6 of Myotonin-protein kinase - Isoform 7 of Myotonin-protein kinase - Isoform 8 of Myotonin-protein kinase - Isoform 9 of Myotonin-protein kinase - Isoform 10 of Myotonin-protein kinaseSequence View
10 20 30 40 50 60
MSAEVRLRQL QQLVLDPGFL GLEPLLDLLL GVHQELGASH LAQDKYVADF LQWVEPIAAR
70 80 90 100 110 120
LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER
130 140 150 160 170 180
DVLVKGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV
190 200 210 220 230 240
MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL QPDGMVRSLV AVGTPDYLSP
250 260 270 280 290 300
EILQAVGGGP GAGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYAKI VHYREHLSLP
310 320 330 340 350 360
LADTVVPEEA QDLIRGLLCP AEIRLGRGGA GDFQKHPFFF GLDWEGLRDS VPPFTPDFEG
370 380 390 400 410 420
ATDTCNFDVV EDRLTAMVSG GGETLSDMQE DMPLGVRLPF VGYSYCCMAF RDNQVPDPTP
430 440 450 460 470 480
MELEALQLPV SDLQGLDLQP PVSPPDQVAE EADLVAVPAP VAEAETTVTL QQLQEALEEE
490 500 510 520 530 540
VLTRQSLSRE LEAIRTANQN FSSQLQEAEV RNRDLEAHVR QLQERMEMLQ APGAAAITGV
550 560 570 580 590 600
PSPRATDPPS HLDGPPAVAV GQCPLVGPGP MHRRHLLLPA RIPRPGLSEA RCLLLFAAAL
610 620 630
AAAATLGCTG LVAYTGGLTP VWCFPGATFA P
10 20 30 40 50 60
MSAEVRLRQL QQLVLDPGFL GLEPLLDLLL GVHQELGASH LAQDKYVADF LQWVEPIAAR
70 80 90 100 110 120
LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER
130 140 150 160 170 180
DVLVKGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV
190 200 210 220 230 240
MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL QPDGMVRSLV AVGTPDYLSP
250 260 270 280 290 300
EILQAVGGGP GAGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYAKI VHYREHLSLP
310 320 330 340 350 360
LADTVVPEEA QDLIRGLLCP AEIRLGRGGA GDFQKHPFFF GLDWEGLRDS VPPFTPDFEG
370 380 390 400 410 420
ATDTCNFDVV EDRLTAMVSG GGETLSDMQE DMPLGVRLPF VGYSYCCMAF RDNQVPDPTP
430 440 450 460 470 480
MELEALQLPV SDLQGLDLQP PVSPPDQVAE EADLVAVPAP VAEAETTVTL QQLQEALEEE
490 500 510 520 530 540
VLTRQSLSRE LEAIRTANQN FSSQLQEAEV RNRDLEAHVR QLQERMEMLQ APGAAAITGV
550 560 570 580 590 600
PSPRATDPPS HLDGPPAVAV GQCPLVGPGP MHRRHLLLPA RIPRPGLSEA RCLLLFAAAL
610 620 630
AAAATLGCTG LVAYTGGLTP VWCFPGATFA P
10 20 30 40 50 60
MSAEVRLRQL QQLVLDPGFL GLEPLLDLLL GVHQELGASH LAQDKYVADF LQWVEPIAAR
70 80 90 100 110 120
LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER
130 140 150 160 170 180
DVLVKGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV
190 200 210 220 230 240
MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL QPDGMVRSLV AVGTPDYLSP
250 260 270 280 290 300
EILQAVGGGP GAGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYAKI VHYREHLSLP
310 320 330 340 350 360
LADTVVPEEA QDLIRGLLCP AEIRLGRGGA GDFQKHPFFF GLDWEGLRDS VPPFTPDFEG
370 380 390 400 410 420
ATDTCNFDVV EDRLTAMVSG GGETLSDMQE DMPLGVRLPF VGYSYCCMAF RDNQVPDPTP
430 440 450 460 470 480
MELEALQLPV SDLQGLDLQP PVSPPDQVAE EADLVAVPAP VAEAETTVTL QQLQEALEEE
490 500 510 520 530 540
VLTRQSLSRE LEAIRTANQN FSSQLQEAEV RNRDLEAHVR QLQERMEMLQ APGAAAITGV
550 560 570 580 590 600
PSPRATDPPS HLDGPPAVAV GQCPLVGPGP MHRRHLLLPA RIPRPGLSEA RCLLLFAAAL
610 620 630
AAAATLGCTG LVAYTGGLTP VWCFPGATFA P
10 20 30 40 50 60
MSAEVRLRQL QQLVLDPGFL GLEPLLDLLL GVHQELGASH LAQDKYVADF LQWVEPIAAR
70 80 90 100 110 120
LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER
130 140 150 160 170 180
DVLVKGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV
190 200 210 220 230 240
MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL QPDGMVRSLV AVGTPDYLSP
250 260 270 280 290 300
EILQAVGGGP GAGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYAKI VHYREHLSLP
310 320 330 340 350 360
LADTVVPEEA QDLIRGLLCP AEIRLGRGGA GDFQKHPFFF GLDWEGLRDS VPPFTPDFEG
370 380 390 400 410 420
ATDTCNFDVV EDRLTAMVSG GGETLSDMQE DMPLGVRLPF VGYSYCCMAF RDNQVPDPTP
430 440 450 460 470 480
MELEALQLPV SDLQGLDLQP PVSPPDQVAE EADLVAVPAP VAEAETTVTL QQLQEALEEE
490 500 510 520 530 540
VLTRQSLSRE LEAIRTANQN FSSQLQEAEV RNRDLEAHVR QLQERMEMLQ APGAAAITGV
550 560 570 580 590 600
PSPRATDPPS HLDGPPAVAV GQCPLVGPGP MHRRHLLLPA RIPRPGLSEA RCLLLFAAAL
610 620 630
AAAATLGCTG LVAYTGGLTP VWCFPGATFA P
10 20 30 40 50 60
MSAEVRLRQL QQLVLDPGFL GLEPLLDLLL GVHQELGASH LAQDKYVADF LQWVEPIAAR
70 80 90 100 110 120
LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER
130 140 150 160 170 180
DVLVKGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV
190 200 210 220 230 240
MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL QPDGMVRSLV AVGTPDYLSP
250 260 270 280 290 300
EILQAVGGGP GAGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYAKI VHYREHLSLP
310 320 330 340 350 360
LADTVVPEEA QDLIRGLLCP AEIRLGRGGA GDFQKHPFFF GLDWEGLRDS VPPFTPDFEG
370 380 390 400 410 420
ATDTCNFDVV EDRLTAMVSG GGETLSDMQE DMPLGVRLPF VGYSYCCMAF RDNQVPDPTP
430 440 450 460 470 480
MELEALQLPV SDLQGLDLQP PVSPPDQVAE EADLVAVPAP VAEAETTVTL QQLQEALEEE
490 500 510 520 530 540
VLTRQSLSRE LEAIRTANQN FSSQLQEAEV RNRDLEAHVR QLQERMEMLQ APGAAAITGV
550 560 570 580 590 600
PSPRATDPPS HLDGPPAVAV GQCPLVGPGP MHRRHLLLPA RIPRPGLSEA RCLLLFAAAL
610 620 630
AAAATLGCTG LVAYTGGLTP VWCFPGATFA P
10 20 30 40 50 60
MSAEVRLRQL QQLVLDPGFL GLEPLLDLLL GVHQELGASH LAQDKYVADF LQWVEPIAAR
70 80 90 100 110 120
LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER
130 140 150 160 170 180
DVLVKGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV
190 200 210 220 230 240
MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL QPDGMVRSLV AVGTPDYLSP
250 260 270 280 290 300
EILQAVGGGP GAGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYAKI VHYREHLSLP
310 320 330 340 350 360
LADTVVPEEA QDLIRGLLCP AEIRLGRGGA GDFQKHPFFF GLDWEGLRDS VPPFTPDFEG
370 380 390 400 410 420
ATDTCNFDVV EDRLTAMVSG GGETLSDMQE DMPLGVRLPF VGYSYCCMAF RDNQVPDPTP
430 440 450 460 470 480
MELEALQLPV SDLQGLDLQP PVSPPDQVAE EADLVAVPAP VAEAETTVTL QQLQEALEEE
490 500 510 520 530 540
VLTRQSLSRE LEAIRTANQN FSSQLQEAEV RNRDLEAHVR QLQERMEMLQ APGAAAITGV
550 560 570 580 590 600
PSPRATDPPS HLDGPPAVAV GQCPLVGPGP MHRRHLLLPA RIPRPGLSEA RCLLLFAAAL
610 620 630
AAAATLGCTG LVAYTGGLTP VWCFPGATFA P
10 20 30 40 50 60
MSAEVRLRQL QQLVLDPGFL GLEPLLDLLL GVHQELGASH LAQDKYVADF LQWVEPIAAR
70 80 90 100 110 120
LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER
130 140 150 160 170 180
DVLVKGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV
190 200 210 220 230 240
MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL QPDGMVRSLV AVGTPDYLSP
250 260 270 280 290 300
EILQAVGGGP GAGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYAKI VHYREHLSLP
310 320 330 340 350 360
LADTVVPEEA QDLIRGLLCP AEIRLGRGGA GDFQKHPFFF GLDWEGLRDS VPPFTPDFEG
370 380 390 400 410 420
ATDTCNFDVV EDRLTAMVSG GGETLSDMQE DMPLGVRLPF VGYSYCCMAF RDNQVPDPTP
430 440 450 460 470 480
MELEALQLPV SDLQGLDLQP PVSPPDQVAE EADLVAVPAP VAEAETTVTL QQLQEALEEE
490 500 510 520 530 540
VLTRQSLSRE LEAIRTANQN FSSQLQEAEV RNRDLEAHVR QLQERMEMLQ APGAAAITGV
550 560 570 580 590 600
PSPRATDPPS HLDGPPAVAV GQCPLVGPGP MHRRHLLLPA RIPRPGLSEA RCLLLFAAAL
610 620 630
AAAATLGCTG LVAYTGGLTP VWCFPGATFA P
10 20 30 40 50 60
MSAEVRLRQL QQLVLDPGFL GLEPLLDLLL GVHQELGASH LAQDKYVADF LQWVEPIAAR
70 80 90 100 110 120
LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER
130 140 150 160 170 180
DVLVKGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV
190 200 210 220 230 240
MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL QPDGMVRSLV AVGTPDYLSP
250 260 270 280 290 300
EILQAVGGGP GAGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYAKI VHYREHLSLP
310 320 330 340 350 360
LADTVVPEEA QDLIRGLLCP AEIRLGRGGA GDFQKHPFFF GLDWEGLRDS VPPFTPDFEG
370 380 390 400 410 420
ATDTCNFDVV EDRLTAMVSG GGETLSDMQE DMPLGVRLPF VGYSYCCMAF RDNQVPDPTP
430 440 450 460 470 480
MELEALQLPV SDLQGLDLQP PVSPPDQVAE EADLVAVPAP VAEAETTVTL QQLQEALEEE
490 500 510 520 530 540
VLTRQSLSRE LEAIRTANQN FSSQLQEAEV RNRDLEAHVR QLQERMEMLQ APGAAAITGV
550 560 570 580 590 600
PSPRATDPPS HLDGPPAVAV GQCPLVGPGP MHRRHLLLPA RIPRPGLSEA RCLLLFAAAL
610 620 630
AAAATLGCTG LVAYTGGLTP VWCFPGATFA P
10 20 30 40 50 60
MSAEVRLRQL QQLVLDPGFL GLEPLLDLLL GVHQELGASH LAQDKYVADF LQWVEPIAAR
70 80 90 100 110 120
LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER
130 140 150 160 170 180
DVLVKGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV
190 200 210 220 230 240
MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL QPDGMVRSLV AVGTPDYLSP
250 260 270 280 290 300
EILQAVGGGP GAGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYAKI VHYREHLSLP
310 320 330 340 350 360
LADTVVPEEA QDLIRGLLCP AEIRLGRGGA GDFQKHPFFF GLDWEGLRDS VPPFTPDFEG
370 380 390 400 410 420
ATDTCNFDVV EDRLTAMVSG GGETLSDMQE DMPLGVRLPF VGYSYCCMAF RDNQVPDPTP
430 440 450 460 470 480
MELEALQLPV SDLQGLDLQP PVSPPDQVAE EADLVAVPAP VAEAETTVTL QQLQEALEEE
490 500 510 520 530 540
VLTRQSLSRE LEAIRTANQN FSSQLQEAEV RNRDLEAHVR QLQERMEMLQ APGAAAITGV
550 560 570 580 590 600
PSPRATDPPS HLDGPPAVAV GQCPLVGPGP MHRRHLLLPA RIPRPGLSEA RCLLLFAAAL
610 620 630
AAAATLGCTG LVAYTGGLTP VWCFPGATFA P
Protein Neighborhood
Domains & Features
1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| P54265-1-unknown | MSAEVR... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P54265-1-unknown | MSAEVR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt72996 | |||
| P54265-1-unknown | MSAEVR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt72997 | |||
| P54265-1-unknown | MSAEVR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt72998 | |||
| P54265-1-unknown | MSAEVR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt72999 | |||
| P54265-1-unknown | MSAEVR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt73000 | |||
| P54265-1-unknown | MSAEVR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt73001 | |||
| P54265-1-unknown | MSAEVR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt73002 | |||
| P54265-1-unknown | MSAEVR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt73003 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...ATFAP | 631 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...ATFAP | 631 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt68614 | |||
| ...ATFAP | 631 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt68615 |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|