TopFIND 4.0

P54830: Tyrosine-protein phosphatase non-receptor type 5

General Information

Protein names
- Tyrosine-protein phosphatase non-receptor type 5
- 3.1.3.48
- Neural-specific protein-tyrosine phosphatase
- Striatum-enriched protein-tyrosine phosphatase
- STEP
Gene names Ptpn5
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID P54830

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MCCSERLLGL PQPVEMEAPD EAEGLPSKQK EMPPPPPPSP PSEPAQKLPP QGAGSHSLTV 
        70         80         90        100        110        120 
RSSLCLFAAS QFLLACGVLW LSGHGHSWLQ NTTDLISSSL TVLNHLGPVA WLGSGTWGIP 
       130        140        150        160        170        180 
SLLLVSLTVS LVIVTTLVWH LLKAPPEPPA PLPPEDRRQS VSRQPSFTYS EWMEEKVEDD 
       190        200        210        220        230        240 
FLDLDAVPET PVFDCVMDIK PETDPASLTV KSMGLQERRG SNVSLTLDMC TPGCNEEGFG 
       250        260        270        280        290        300 
YLVSPREESA HEYLLSASRV LRAEELHEKA LDPFLLQAEF FEIPMNFVDP KEYDIPGLVR 
       310        320        330        340        350        360 
KNRYKTILPN PHSRVRLTSP DPEDPLSSYI NANYIRGYSG EEKVYIATQG PIVSTVADFW 
       370        380        390        400        410        420 
RMVWQERTPI IVMITNIEEM NEKCTEYWPE EQVVHDGVEI TVQKVIHTED YRLRLISLRR 
       430        440        450        460        470        480 
GTEERSLKHY WFTSWPDQKT PDRAPPLLHL VREVEEAAQQ EGPHCSPIIV HCSAGIGRTG 
       490        500        510        520        530        540 
CFIATSICCQ QLRREGVVDI LKTTCQLRQD RGGMIQTCEQ YQFVHHAMSL YEKQLSLQSS 
   
E

Isoforms

- Isoform STEP46 of Tyrosine-protein phosphatase non-receptor type 5 - Isoform STEP38 of Tyrosine-protein phosphatase non-receptor type 5 - Isoform STEP20 of Tyrosine-protein phosphatase non-receptor type 5

Sequence View

        10         20         30         40         50         60 
MCCSERLLGL PQPVEMEAPD EAEGLPSKQK EMPPPPPPSP PSEPAQKLPP QGAGSHSLTV 
        70         80         90        100        110        120 
RSSLCLFAAS QFLLACGVLW LSGHGHSWLQ NTTDLISSSL TVLNHLGPVA WLGSGTWGIP 
       130        140        150        160        170        180 
SLLLVSLTVS LVIVTTLVWH LLKAPPEPPA PLPPEDRRQS VSRQPSFTYS EWMEEKVEDD 
       190        200        210        220        230        240 
FLDLDAVPET PVFDCVMDIK PETDPASLTV KSMGLQERRG SNVSLTLDMC TPGCNEEGFG 
       250        260        270        280        290        300 
YLVSPREESA HEYLLSASRV LRAEELHEKA LDPFLLQAEF FEIPMNFVDP KEYDIPGLVR 
       310        320        330        340        350        360 
KNRYKTILPN PHSRVRLTSP DPEDPLSSYI NANYIRGYSG EEKVYIATQG PIVSTVADFW 
       370        380        390        400        410        420 
RMVWQERTPI IVMITNIEEM NEKCTEYWPE EQVVHDGVEI TVQKVIHTED YRLRLISLRR 
       430        440        450        460        470        480 
GTEERSLKHY WFTSWPDQKT PDRAPPLLHL VREVEEAAQQ EGPHCSPIIV HCSAGIGRTG 
       490        500        510        520        530        540 
CFIATSICCQ QLRREGVVDI LKTTCQLRQD RGGMIQTCEQ YQFVHHAMSL YEKQLSLQSS 
   
E         10         20         30         40         50         60 
MCCSERLLGL PQPVEMEAPD EAEGLPSKQK EMPPPPPPSP PSEPAQKLPP QGAGSHSLTV 
        70         80         90        100        110        120 
RSSLCLFAAS QFLLACGVLW LSGHGHSWLQ NTTDLISSSL TVLNHLGPVA WLGSGTWGIP 
       130        140        150        160        170        180 
SLLLVSLTVS LVIVTTLVWH LLKAPPEPPA PLPPEDRRQS VSRQPSFTYS EWMEEKVEDD 
       190        200        210        220        230        240 
FLDLDAVPET PVFDCVMDIK PETDPASLTV KSMGLQERRG SNVSLTLDMC TPGCNEEGFG 
       250        260        270        280        290        300 
YLVSPREESA HEYLLSASRV LRAEELHEKA LDPFLLQAEF FEIPMNFVDP KEYDIPGLVR 
       310        320        330        340        350        360 
KNRYKTILPN PHSRVRLTSP DPEDPLSSYI NANYIRGYSG EEKVYIATQG PIVSTVADFW 
       370        380        390        400        410        420 
RMVWQERTPI IVMITNIEEM NEKCTEYWPE EQVVHDGVEI TVQKVIHTED YRLRLISLRR 
       430        440        450        460        470        480 
GTEERSLKHY WFTSWPDQKT PDRAPPLLHL VREVEEAAQQ EGPHCSPIIV HCSAGIGRTG 
       490        500        510        520        530        540 
CFIATSICCQ QLRREGVVDI LKTTCQLRQD RGGMIQTCEQ YQFVHHAMSL YEKQLSLQSS 
   
E         10         20         30         40         50         60 
MCCSERLLGL PQPVEMEAPD EAEGLPSKQK EMPPPPPPSP PSEPAQKLPP QGAGSHSLTV 
        70         80         90        100        110        120 
RSSLCLFAAS QFLLACGVLW LSGHGHSWLQ NTTDLISSSL TVLNHLGPVA WLGSGTWGIP 
       130        140        150        160        170        180 
SLLLVSLTVS LVIVTTLVWH LLKAPPEPPA PLPPEDRRQS VSRQPSFTYS EWMEEKVEDD 
       190        200        210        220        230        240 
FLDLDAVPET PVFDCVMDIK PETDPASLTV KSMGLQERRG SNVSLTLDMC TPGCNEEGFG 
       250        260        270        280        290        300 
YLVSPREESA HEYLLSASRV LRAEELHEKA LDPFLLQAEF FEIPMNFVDP KEYDIPGLVR 
       310        320        330        340        350        360 
KNRYKTILPN PHSRVRLTSP DPEDPLSSYI NANYIRGYSG EEKVYIATQG PIVSTVADFW 
       370        380        390        400        410        420 
RMVWQERTPI IVMITNIEEM NEKCTEYWPE EQVVHDGVEI TVQKVIHTED YRLRLISLRR 
       430        440        450        460        470        480 
GTEERSLKHY WFTSWPDQKT PDRAPPLLHL VREVEEAAQQ EGPHCSPIIV HCSAGIGRTG 
       490        500        510        520        530        540 
CFIATSICCQ QLRREGVVDI LKTTCQLRQD RGGMIQTCEQ YQFVHHAMSL YEKQLSLQSS 
   
E



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LQSSE 541 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...LQSSE 541 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt82144

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)