TopFIND 4.0

P56282: DNA polymerase epsilon subunit 2

General Information

Protein names
- DNA polymerase epsilon subunit 2
- 2.7.7.7
- DNA polymerase II subunit 2
- DNA polymerase epsilon subunit B
Gene names POLE2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P56282

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAPERLRSRA LSAFKLRGLL LRGEAIKYLT EALQSISELE LEDKLEKIIN AVEKQPLSSN 
        70         80         90        100        110        120 
MIERSVVEAA VQECSQSVDE TIEHVFNIIG AFDIPRFVYN SERKKFLPLL MTNHPAPNLF 
       130        140        150        160        170        180 
GTPRDKAEMF RERYTILHQR THRHELFTPP VIGSHPDESG SKFQLKTIET LLGSTTKIGD 
       190        200        210        220        230        240 
AIVLGMITQL KEGKFFLEDP TGTVQLDLSK AQFHSGLYTE ACFVLAEGWF EDQVFHVNAF 
       250        260        270        280        290        300 
GFPPTEPSST TRAYYGNINF FGGPSNTSVK TSAKLKQLEE ENKDAMFVFL SDVWLDQVEV 
       310        320        330        340        350        360 
LEKLRIMFAG YSPAPPTCFI LCGNFSSAPY GKNQVQALKD SLKTLADIIC EYPDIHQSSR 
       370        380        390        400        410        420 
FVFVPGPEDP GFGSILPRPP LAESITNEFR QRVPFSVFTT NPCRIQYCTQ EITVFREDLV 
       430        440        450        460        470        480 
NKMCRNCVRF PSSNLAIPNH FVKTILSQGH LTPLPLYVCP VYWAYDYALR VYPVPDLLVI 
       490        500        510        520    
ADKYDPFTTT NTECLCINPG SFPRSGFSFK VFYPSNKTVE DSKLQGF

Isoforms

- Isoform 2 of DNA polymerase epsilon subunit 2 - Isoform 3 of DNA polymerase epsilon subunit 2

Sequence View

        10         20         30         40         50         60 
MAPERLRSRA LSAFKLRGLL LRGEAIKYLT EALQSISELE LEDKLEKIIN AVEKQPLSSN 
        70         80         90        100        110        120 
MIERSVVEAA VQECSQSVDE TIEHVFNIIG AFDIPRFVYN SERKKFLPLL MTNHPAPNLF 
       130        140        150        160        170        180 
GTPRDKAEMF RERYTILHQR THRHELFTPP VIGSHPDESG SKFQLKTIET LLGSTTKIGD 
       190        200        210        220        230        240 
AIVLGMITQL KEGKFFLEDP TGTVQLDLSK AQFHSGLYTE ACFVLAEGWF EDQVFHVNAF 
       250        260        270        280        290        300 
GFPPTEPSST TRAYYGNINF FGGPSNTSVK TSAKLKQLEE ENKDAMFVFL SDVWLDQVEV 
       310        320        330        340        350        360 
LEKLRIMFAG YSPAPPTCFI LCGNFSSAPY GKNQVQALKD SLKTLADIIC EYPDIHQSSR 
       370        380        390        400        410        420 
FVFVPGPEDP GFGSILPRPP LAESITNEFR QRVPFSVFTT NPCRIQYCTQ EITVFREDLV 
       430        440        450        460        470        480 
NKMCRNCVRF PSSNLAIPNH FVKTILSQGH LTPLPLYVCP VYWAYDYALR VYPVPDLLVI 
       490        500        510        520    
ADKYDPFTTT NTECLCINPG SFPRSGFSFK VFYPSNKTVE DSKLQGF         10         20         30         40         50         60 
MAPERLRSRA LSAFKLRGLL LRGEAIKYLT EALQSISELE LEDKLEKIIN AVEKQPLSSN 
        70         80         90        100        110        120 
MIERSVVEAA VQECSQSVDE TIEHVFNIIG AFDIPRFVYN SERKKFLPLL MTNHPAPNLF 
       130        140        150        160        170        180 
GTPRDKAEMF RERYTILHQR THRHELFTPP VIGSHPDESG SKFQLKTIET LLGSTTKIGD 
       190        200        210        220        230        240 
AIVLGMITQL KEGKFFLEDP TGTVQLDLSK AQFHSGLYTE ACFVLAEGWF EDQVFHVNAF 
       250        260        270        280        290        300 
GFPPTEPSST TRAYYGNINF FGGPSNTSVK TSAKLKQLEE ENKDAMFVFL SDVWLDQVEV 
       310        320        330        340        350        360 
LEKLRIMFAG YSPAPPTCFI LCGNFSSAPY GKNQVQALKD SLKTLADIIC EYPDIHQSSR 
       370        380        390        400        410        420 
FVFVPGPEDP GFGSILPRPP LAESITNEFR QRVPFSVFTT NPCRIQYCTQ EITVFREDLV 
       430        440        450        460        470        480 
NKMCRNCVRF PSSNLAIPNH FVKTILSQGH LTPLPLYVCP VYWAYDYALR VYPVPDLLVI 
       490        500        510        520    
ADKYDPFTTT NTECLCINPG SFPRSGFSFK VFYPSNKTVE DSKLQGF



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P56282-1-unknown MAPERL... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P56282-1-unknown MAPERL... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt73198
    P56282-1-unknown MAPERL... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt73199

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...KLQGF 527 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...KLQGF 527 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt68816

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)