P57727: Transmembrane protease serine 3

General Information

Protein names	- Transmembrane protease serine 3 - 3.4.21.- - Serine protease TADG-12 - Tumor-associated differentially-expressed gene 12 protein
Gene names	TMPRSS3
Organism	Homo sapiens
Protease Family
Protease ID	S01.079
Chromosome location
UniProt ID	P57727

2 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform B of Transmembrane protease serine 3 - Isoform D of Transmembrane protease serine 3 - Isoform T of Transmembrane protease serine 3 - Isoform E of Transmembrane protease serine 3 - Isoform 6 of Transmembrane protease serine 3

Sequence View

        10         20         30         40         50         60
MGENDPPAVE APFSFRSLFG LDDLKISPVA PDADAVAAQI LSLLPLKFFP IIVIGIIALI
        70         80         90        100        110        120
LALAIGLGIH FDCSGKYRCR SSFKCIELIA RCDGVSDCKD GEDEYRCVRV GGQNAVLQVF
       130        140        150        160        170        180
TAASWKTMCS DDWKGHYANV ACAQLGFPSY VSSDNLRVSS LEGQFREEFV SIDHLLPDDK
       190        200        210        220        230        240
VTALHHSVYV REGCASGHVV TLQCTACGHR RGYSSRIVGG NMSLLSQWPW QASLQFQGYH
       250        260        270        280        290        300
LCGGSVITPL WIITAAHCVY DLYLPKSWTI QVGLVSLLDN PAPSHLVEKI VYHSKYKPKR
       310        320        330        340        350        360
LGNDIALMKL AGPLTFNEMI QPVCLPNSEE NFPDGKVCWT SGWGATEDGA GDASPVLNHA
       370        380        390        400        410        420
AVPLISNKIC NHRDVYGGII SPSMLCAGYL TGGVDSCQGD SGGPLVCQER RLWKLVGATS
       430        440        450
FGIGCAEVNK PGVYTRVTSF LDWIHEQMER DLKT         10         20         30         40         50         60
MGENDPPAVE APFSFRSLFG LDDLKISPVA PDADAVAAQI LSLLPLKFFP IIVIGIIALI
        70         80         90        100        110        120
LALAIGLGIH FDCSGKYRCR SSFKCIELIA RCDGVSDCKD GEDEYRCVRV GGQNAVLQVF
       130        140        150        160        170        180
TAASWKTMCS DDWKGHYANV ACAQLGFPSY VSSDNLRVSS LEGQFREEFV SIDHLLPDDK
       190        200        210        220        230        240
VTALHHSVYV REGCASGHVV TLQCTACGHR RGYSSRIVGG NMSLLSQWPW QASLQFQGYH
       250        260        270        280        290        300
LCGGSVITPL WIITAAHCVY DLYLPKSWTI QVGLVSLLDN PAPSHLVEKI VYHSKYKPKR
       310        320        330        340        350        360
LGNDIALMKL AGPLTFNEMI QPVCLPNSEE NFPDGKVCWT SGWGATEDGA GDASPVLNHA
       370        380        390        400        410        420
AVPLISNKIC NHRDVYGGII SPSMLCAGYL TGGVDSCQGD SGGPLVCQER RLWKLVGATS
       430        440        450
FGIGCAEVNK PGVYTRVTSF LDWIHEQMER DLKT         10         20         30         40         50         60
MGENDPPAVE APFSFRSLFG LDDLKISPVA PDADAVAAQI LSLLPLKFFP IIVIGIIALI
        70         80         90        100        110        120
LALAIGLGIH FDCSGKYRCR SSFKCIELIA RCDGVSDCKD GEDEYRCVRV GGQNAVLQVF
       130        140        150        160        170        180
TAASWKTMCS DDWKGHYANV ACAQLGFPSY VSSDNLRVSS LEGQFREEFV SIDHLLPDDK
       190        200        210        220        230        240
VTALHHSVYV REGCASGHVV TLQCTACGHR RGYSSRIVGG NMSLLSQWPW QASLQFQGYH
       250        260        270        280        290        300
LCGGSVITPL WIITAAHCVY DLYLPKSWTI QVGLVSLLDN PAPSHLVEKI VYHSKYKPKR
       310        320        330        340        350        360
LGNDIALMKL AGPLTFNEMI QPVCLPNSEE NFPDGKVCWT SGWGATEDGA GDASPVLNHA
       370        380        390        400        410        420
AVPLISNKIC NHRDVYGGII SPSMLCAGYL TGGVDSCQGD SGGPLVCQER RLWKLVGATS
       430        440        450
FGIGCAEVNK PGVYTRVTSF LDWIHEQMER DLKT         10         20         30         40         50         60
MGENDPPAVE APFSFRSLFG LDDLKISPVA PDADAVAAQI LSLLPLKFFP IIVIGIIALI
        70         80         90        100        110        120
LALAIGLGIH FDCSGKYRCR SSFKCIELIA RCDGVSDCKD GEDEYRCVRV GGQNAVLQVF
       130        140        150        160        170        180
TAASWKTMCS DDWKGHYANV ACAQLGFPSY VSSDNLRVSS LEGQFREEFV SIDHLLPDDK
       190        200        210        220        230        240
VTALHHSVYV REGCASGHVV TLQCTACGHR RGYSSRIVGG NMSLLSQWPW QASLQFQGYH
       250        260        270        280        290        300
LCGGSVITPL WIITAAHCVY DLYLPKSWTI QVGLVSLLDN PAPSHLVEKI VYHSKYKPKR
       310        320        330        340        350        360
LGNDIALMKL AGPLTFNEMI QPVCLPNSEE NFPDGKVCWT SGWGATEDGA GDASPVLNHA
       370        380        390        400        410        420
AVPLISNKIC NHRDVYGGII SPSMLCAGYL TGGVDSCQGD SGGPLVCQER RLWKLVGATS
       430        440        450
FGIGCAEVNK PGVYTRVTSF LDWIHEQMER DLKT         10         20         30         40         50         60
MGENDPPAVE APFSFRSLFG LDDLKISPVA PDADAVAAQI LSLLPLKFFP IIVIGIIALI
        70         80         90        100        110        120
LALAIGLGIH FDCSGKYRCR SSFKCIELIA RCDGVSDCKD GEDEYRCVRV GGQNAVLQVF
       130        140        150        160        170        180
TAASWKTMCS DDWKGHYANV ACAQLGFPSY VSSDNLRVSS LEGQFREEFV SIDHLLPDDK
       190        200        210        220        230        240
VTALHHSVYV REGCASGHVV TLQCTACGHR RGYSSRIVGG NMSLLSQWPW QASLQFQGYH
       250        260        270        280        290        300
LCGGSVITPL WIITAAHCVY DLYLPKSWTI QVGLVSLLDN PAPSHLVEKI VYHSKYKPKR
       310        320        330        340        350        360
LGNDIALMKL AGPLTFNEMI QPVCLPNSEE NFPDGKVCWT SGWGATEDGA GDASPVLNHA
       370        380        390        400        410        420
AVPLISNKIC NHRDVYGGII SPSMLCAGYL TGGVDSCQGD SGGPLVCQER RLWKLVGATS
       430        440        450
FGIGCAEVNK PGVYTRVTSF LDWIHEQMER DLKT

Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P57727-1-unknown	MGENDP...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P57727-1-unknown	MGENDP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92540
P57727-1-unknown	MGENDP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92541
P57727-1-unknown	MGENDP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92542
P57727-1-unknown	MGENDP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt100977
P57727-128-unknown	MCSDDW...	128	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92539
P57727-128-unknown	MCSDDW...	128	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102905
P57727-128-unknown	MCSDDW...	128	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102906
P57727-128-unknown	MCSDDW...	128	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102907
P57727-128-unknown	MCSDDW...	128	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102904

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RDLKT	454	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RDLKT	454	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88157
...RDLKT	454	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88160
...RDLKT	454	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88161

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

TopFIND

P57727: Transmembrane protease serine 3

General Information

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates