P58005: Sestrin-3 {ECO:0000305}

General Information

Protein names	- Sestrin-3 {ECO:0000305}
Gene names	SESN3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P58005

2 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Sestrin-3 - Isoform 3 of Sestrin-3 - Isoform 4 of Sestrin-3 - Isoform 2 of Sestrin-3

Sequence View

        10         20         30         40         50         60
MNRGGGSPSA AANYLLCTNC RKVLRKDKRI RVSQPLTRGP SAFIPEKEVV QANTVDERTN
        70         80         90        100        110        120
FLVEEYSTSG RLDNITQVMS LHTQYLESFL RSQFYMLRMD GPLPLPYRHY IAIMAAARHQ
       130        140        150        160        170        180
CSYLINMHVD EFLKTGGIAE WLNGLEYVPQ RLKNLNEINK LLAHRPWLIT KEHIQKLVKT
       190        200        210        220        230        240
GENNWSLPEL VHAVVLLAHY HALASFVFGS GINPERDPEI SNGFRLISVN NFCVCDLAND
       250        260        270        280        290        300
NNIENASLSG SNFGIVDSLS ELEALMERMK RLQEEREDEE ASQEEMSTRF EKEKKESLFV
       310        320        330        340        350        360
VSGDTFHSFP HSDFEDDMII TSDVSRYIED PGFGYEDFAR RGEEHLPTFR AQDYTWENHG
       370        380        390        400        410        420
FSLVNRLYSD IGHLLDEKFR MVYNLTYNTM ATHEDVDTTM LRRALFNYVH CMFGIRYDDY
       430        440        450        460        470        480
DYGEVNQLLE RSLKVYIKTV TCYPERTTKR MYDSYWRQFK HSEKVHVNLL LMEARMQAEL
       490
LYALRAITRH LT         10         20         30         40         50         60
MNRGGGSPSA AANYLLCTNC RKVLRKDKRI RVSQPLTRGP SAFIPEKEVV QANTVDERTN
        70         80         90        100        110        120
FLVEEYSTSG RLDNITQVMS LHTQYLESFL RSQFYMLRMD GPLPLPYRHY IAIMAAARHQ
       130        140        150        160        170        180
CSYLINMHVD EFLKTGGIAE WLNGLEYVPQ RLKNLNEINK LLAHRPWLIT KEHIQKLVKT
       190        200        210        220        230        240
GENNWSLPEL VHAVVLLAHY HALASFVFGS GINPERDPEI SNGFRLISVN NFCVCDLAND
       250        260        270        280        290        300
NNIENASLSG SNFGIVDSLS ELEALMERMK RLQEEREDEE ASQEEMSTRF EKEKKESLFV
       310        320        330        340        350        360
VSGDTFHSFP HSDFEDDMII TSDVSRYIED PGFGYEDFAR RGEEHLPTFR AQDYTWENHG
       370        380        390        400        410        420
FSLVNRLYSD IGHLLDEKFR MVYNLTYNTM ATHEDVDTTM LRRALFNYVH CMFGIRYDDY
       430        440        450        460        470        480
DYGEVNQLLE RSLKVYIKTV TCYPERTTKR MYDSYWRQFK HSEKVHVNLL LMEARMQAEL
       490
LYALRAITRH LT         10         20         30         40         50         60
MNRGGGSPSA AANYLLCTNC RKVLRKDKRI RVSQPLTRGP SAFIPEKEVV QANTVDERTN
        70         80         90        100        110        120
FLVEEYSTSG RLDNITQVMS LHTQYLESFL RSQFYMLRMD GPLPLPYRHY IAIMAAARHQ
       130        140        150        160        170        180
CSYLINMHVD EFLKTGGIAE WLNGLEYVPQ RLKNLNEINK LLAHRPWLIT KEHIQKLVKT
       190        200        210        220        230        240
GENNWSLPEL VHAVVLLAHY HALASFVFGS GINPERDPEI SNGFRLISVN NFCVCDLAND
       250        260        270        280        290        300
NNIENASLSG SNFGIVDSLS ELEALMERMK RLQEEREDEE ASQEEMSTRF EKEKKESLFV
       310        320        330        340        350        360
VSGDTFHSFP HSDFEDDMII TSDVSRYIED PGFGYEDFAR RGEEHLPTFR AQDYTWENHG
       370        380        390        400        410        420
FSLVNRLYSD IGHLLDEKFR MVYNLTYNTM ATHEDVDTTM LRRALFNYVH CMFGIRYDDY
       430        440        450        460        470        480
DYGEVNQLLE RSLKVYIKTV TCYPERTTKR MYDSYWRQFK HSEKVHVNLL LMEARMQAEL
       490
LYALRAITRH LT         10         20         30         40         50         60
MNRGGGSPSA AANYLLCTNC RKVLRKDKRI RVSQPLTRGP SAFIPEKEVV QANTVDERTN
        70         80         90        100        110        120
FLVEEYSTSG RLDNITQVMS LHTQYLESFL RSQFYMLRMD GPLPLPYRHY IAIMAAARHQ
       130        140        150        160        170        180
CSYLINMHVD EFLKTGGIAE WLNGLEYVPQ RLKNLNEINK LLAHRPWLIT KEHIQKLVKT
       190        200        210        220        230        240
GENNWSLPEL VHAVVLLAHY HALASFVFGS GINPERDPEI SNGFRLISVN NFCVCDLAND
       250        260        270        280        290        300
NNIENASLSG SNFGIVDSLS ELEALMERMK RLQEEREDEE ASQEEMSTRF EKEKKESLFV
       310        320        330        340        350        360
VSGDTFHSFP HSDFEDDMII TSDVSRYIED PGFGYEDFAR RGEEHLPTFR AQDYTWENHG
       370        380        390        400        410        420
FSLVNRLYSD IGHLLDEKFR MVYNLTYNTM ATHEDVDTTM LRRALFNYVH CMFGIRYDDY
       430        440        450        460        470        480
DYGEVNQLLE RSLKVYIKTV TCYPERTTKR MYDSYWRQFK HSEKVHVNLL LMEARMQAEL
       490
LYALRAITRH LT

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P58005-1-unknown	MNRGGG...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P58005-1-unknown	MNRGGG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt89327
P58005-1-unknown	MNRGGG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt89328
P58005-79-unknown	MSLHTQ...	79	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt89329
P58005-79-unknown	MSLHTQ...	79	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000278499
P58005-79-unknown	MSLHTQ...	79	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109266
P58005-79-unknown	MSLHTQ...	79	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109267

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FLRSQF	93	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000439580
...FLRSQF	93	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt110039
...FLRSQF	93	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt110040
...TRHLT	492	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TRHLT	492	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84947

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)