P58397: A disintegrin and metalloproteinase with thrombospondin motifs 12

General Information

Protein names	- A disintegrin and metalloproteinase with thrombospondin motifs 12 - ADAM-TS 12 - ADAM-TS12 - ADAMTS-12 - 3.4.24.-
Gene names	ADAMTS12
Organism	Homo sapiens
Protease Family
Protease ID	M12.237
Chromosome location
UniProt ID	P58397

4 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPCAQRSWLA NLSVVAQLLN FGALCYGRQP QPGPVRFPDR RQEHFIKGLP EYHVVGPVRV
        70         80         90        100        110        120
DASGHFLSYG LHYPITSSRR KRDLDGSEDW VYYRISHEEK DLFFNLTVNQ GFLSNSYIME
       130        140        150        160        170        180
KRYGNLSHVK MMASSAPLCH LSGTVLQQGT RVGTAALSAC HGLTGFFQLP HGDFFIEPVK
       190        200        210        220        230        240
KHPLVEGGYH PHIVYRRQKV PETKEPTCGL KDSVNISQKQ ELWREKWERH NLPSRSLSRR
       250        260        270        280        290        300
SISKERWVET LVVADTKMIE YHGSENVESY ILTIMNMVTG LFHNPSIGNA IHIVVVRLIL
       310        320        330        340        350        360
LEEEEQGLKI VHHAEKTLSS FCKWQKSINP KSDLNPVHHD VAVLLTRKDI CAGFNRPCET
       370        380        390        400        410        420
LGLSHLSGMC QPHRSCNINE DSGLPLAFTI AHELGHSFGI QHDGKENDCE PVGRHPYIMS
       430        440        450        460        470        480
RQLQYDPTPL TWSKCSEEYI TRFLDRGWGF CLDDIPKKKG LKSKVIAPGV IYDVHHQCQL
       490        500        510        520        530        540
QYGPNATFCQ EVENVCQTLW CSVKGFCRSK LDAAADGTQC GEKKWCMAGK CITVGKKPES
       550        560        570        580        590        600
IPGGWGRWSP WSHCSRTCGA GVQSAERLCN NPEPKFGGKY CTGERKRYRL CNVHPCRSEA
       610        620        630        640        650        660
PTFRQMQCSE FDTVPYKNEL YHWFPIFNPA HPCELYCRPI DGQFSEKMLD AVIDGTPCFE
       670        680        690        700        710        720
GGNSRNVCIN GICKMVGCDY EIDSNATEDR CGVCLGDGSS CQTVRKMFKQ KEGSGYVDIG
       730        740        750        760        770        780
LIPKGARDIR VMEIEGAGNF LAIRSEDPEK YYLNGGFIIQ WNGNYKLAGT VFQYDRKGDL
       790        800        810        820        830        840
EKLMATGPTN ESVWIQLLFQ VTNPGIKYEY TIQKDGLDND VEQQMYFWQY GHWTECSVTC
       850        860        870        880        890        900
GTGIRRQTAH CIKKGRGMVK ATFCDPETQP NGRQKKCHEK ACPPRWWAGE WEACSATCGP
       910        920        930        940        950        960
HGEKKRTVLC IQTMVSDEQA LPPTDCQHLL KPKTLLSCNR DILCPSDWTV GNWSECSVSC
       970        980        990       1000       1010       1020
GGGVRIRSVT CAKNHDEPCD VTRKPNSRAL CGLQQCPSSR RVLKPNKGTI SNGKNPPTLK
      1030       1040       1050       1060       1070       1080
PVPPPTSRPR MLTTPTGPES MSTSTPAISS PSPTTASKEG DLGGKQWQDS STQPELSSRY
      1090       1100       1110       1120       1130       1140
LISTGSTSQP ILTSQSLSIQ PSEENVSSSD TGPTSEGGLV ATTTSGSGLS SSRNPITWPV
      1150       1160       1170       1180       1190       1200
TPFYNTLTKG PEMEIHSGSG EEREQPEDKD ESNPVIWTKI RVPGNDAPVE STEMPLAPPL
      1210       1220       1230       1240       1250       1260
TPDLSRESWW PPFSTVMEGL LPSQRPTTSE TGTPRVEGMV TEKPANTLLP LGGDHQPEPS
      1270       1280       1290       1300       1310       1320
GKTANRNHLK LPNNMNQTKS SEPVLTEEDA TSLITEGFLL NASNYKQLTN GHGSAHWIVG
      1330       1340       1350       1360       1370       1380
NWSECSTTCG LGAYWRRVEC STQMDSDCAA IQRPDPAKRC HLRPCAGWKV GNWSKCSRNC
      1390       1400       1410       1420       1430       1440
SGGFKIREIQ CVDSRDHRNL RPFHCQFLAG IPPPLSMSCN PEPCEAWQVE PWSQCSRSCG
      1450       1460       1470       1480       1490       1500
GGVQERGVFC PGGLCDWTKR PTSTMSCNEH LCCHWATGNW DLCSTSCGGG FQKRTVQCVP
      1510       1520       1530       1540       1550       1560
SEGNKTEDQD QCLCDHKPRP PEFKKCNQQA CKKSADLLCT KDKLSASFCQ TLKAMKKCSV
      1570       1580       1590
PTVRAECCFS CPQTHITHTQ RQRRQRLLQK SKEL

Isoforms

- Isoform 2 of A disintegrin and metalloproteinase with thrombospondin motifs 12 - Isoform 3 of A disintegrin and metalloproteinase with thrombospondin motifs 12

Sequence View

        10         20         30         40         50         60
MPCAQRSWLA NLSVVAQLLN FGALCYGRQP QPGPVRFPDR RQEHFIKGLP EYHVVGPVRV
        70         80         90        100        110        120
DASGHFLSYG LHYPITSSRR KRDLDGSEDW VYYRISHEEK DLFFNLTVNQ GFLSNSYIME
       130        140        150        160        170        180
KRYGNLSHVK MMASSAPLCH LSGTVLQQGT RVGTAALSAC HGLTGFFQLP HGDFFIEPVK
       190        200        210        220        230        240
KHPLVEGGYH PHIVYRRQKV PETKEPTCGL KDSVNISQKQ ELWREKWERH NLPSRSLSRR
       250        260        270        280        290        300
SISKERWVET LVVADTKMIE YHGSENVESY ILTIMNMVTG LFHNPSIGNA IHIVVVRLIL
       310        320        330        340        350        360
LEEEEQGLKI VHHAEKTLSS FCKWQKSINP KSDLNPVHHD VAVLLTRKDI CAGFNRPCET
       370        380        390        400        410        420
LGLSHLSGMC QPHRSCNINE DSGLPLAFTI AHELGHSFGI QHDGKENDCE PVGRHPYIMS
       430        440        450        460        470        480
RQLQYDPTPL TWSKCSEEYI TRFLDRGWGF CLDDIPKKKG LKSKVIAPGV IYDVHHQCQL
       490        500        510        520        530        540
QYGPNATFCQ EVENVCQTLW CSVKGFCRSK LDAAADGTQC GEKKWCMAGK CITVGKKPES
       550        560        570        580        590        600
IPGGWGRWSP WSHCSRTCGA GVQSAERLCN NPEPKFGGKY CTGERKRYRL CNVHPCRSEA
       610        620        630        640        650        660
PTFRQMQCSE FDTVPYKNEL YHWFPIFNPA HPCELYCRPI DGQFSEKMLD AVIDGTPCFE
       670        680        690        700        710        720
GGNSRNVCIN GICKMVGCDY EIDSNATEDR CGVCLGDGSS CQTVRKMFKQ KEGSGYVDIG
       730        740        750        760        770        780
LIPKGARDIR VMEIEGAGNF LAIRSEDPEK YYLNGGFIIQ WNGNYKLAGT VFQYDRKGDL
       790        800        810        820        830        840
EKLMATGPTN ESVWIQLLFQ VTNPGIKYEY TIQKDGLDND VEQQMYFWQY GHWTECSVTC
       850        860        870        880        890        900
GTGIRRQTAH CIKKGRGMVK ATFCDPETQP NGRQKKCHEK ACPPRWWAGE WEACSATCGP
       910        920        930        940        950        960
HGEKKRTVLC IQTMVSDEQA LPPTDCQHLL KPKTLLSCNR DILCPSDWTV GNWSECSVSC
       970        980        990       1000       1010       1020
GGGVRIRSVT CAKNHDEPCD VTRKPNSRAL CGLQQCPSSR RVLKPNKGTI SNGKNPPTLK
      1030       1040       1050       1060       1070       1080
PVPPPTSRPR MLTTPTGPES MSTSTPAISS PSPTTASKEG DLGGKQWQDS STQPELSSRY
      1090       1100       1110       1120       1130       1140
LISTGSTSQP ILTSQSLSIQ PSEENVSSSD TGPTSEGGLV ATTTSGSGLS SSRNPITWPV
      1150       1160       1170       1180       1190       1200
TPFYNTLTKG PEMEIHSGSG EEREQPEDKD ESNPVIWTKI RVPGNDAPVE STEMPLAPPL
      1210       1220       1230       1240       1250       1260
TPDLSRESWW PPFSTVMEGL LPSQRPTTSE TGTPRVEGMV TEKPANTLLP LGGDHQPEPS
      1270       1280       1290       1300       1310       1320
GKTANRNHLK LPNNMNQTKS SEPVLTEEDA TSLITEGFLL NASNYKQLTN GHGSAHWIVG
      1330       1340       1350       1360       1370       1380
NWSECSTTCG LGAYWRRVEC STQMDSDCAA IQRPDPAKRC HLRPCAGWKV GNWSKCSRNC
      1390       1400       1410       1420       1430       1440
SGGFKIREIQ CVDSRDHRNL RPFHCQFLAG IPPPLSMSCN PEPCEAWQVE PWSQCSRSCG
      1450       1460       1470       1480       1490       1500
GGVQERGVFC PGGLCDWTKR PTSTMSCNEH LCCHWATGNW DLCSTSCGGG FQKRTVQCVP
      1510       1520       1530       1540       1550       1560
SEGNKTEDQD QCLCDHKPRP PEFKKCNQQA CKKSADLLCT KDKLSASFCQ TLKAMKKCSV
      1570       1580       1590
PTVRAECCFS CPQTHITHTQ RQRRQRLLQK SKEL         10         20         30         40         50         60
MPCAQRSWLA NLSVVAQLLN FGALCYGRQP QPGPVRFPDR RQEHFIKGLP EYHVVGPVRV
        70         80         90        100        110        120
DASGHFLSYG LHYPITSSRR KRDLDGSEDW VYYRISHEEK DLFFNLTVNQ GFLSNSYIME
       130        140        150        160        170        180
KRYGNLSHVK MMASSAPLCH LSGTVLQQGT RVGTAALSAC HGLTGFFQLP HGDFFIEPVK
       190        200        210        220        230        240
KHPLVEGGYH PHIVYRRQKV PETKEPTCGL KDSVNISQKQ ELWREKWERH NLPSRSLSRR
       250        260        270        280        290        300
SISKERWVET LVVADTKMIE YHGSENVESY ILTIMNMVTG LFHNPSIGNA IHIVVVRLIL
       310        320        330        340        350        360
LEEEEQGLKI VHHAEKTLSS FCKWQKSINP KSDLNPVHHD VAVLLTRKDI CAGFNRPCET
       370        380        390        400        410        420
LGLSHLSGMC QPHRSCNINE DSGLPLAFTI AHELGHSFGI QHDGKENDCE PVGRHPYIMS
       430        440        450        460        470        480
RQLQYDPTPL TWSKCSEEYI TRFLDRGWGF CLDDIPKKKG LKSKVIAPGV IYDVHHQCQL
       490        500        510        520        530        540
QYGPNATFCQ EVENVCQTLW CSVKGFCRSK LDAAADGTQC GEKKWCMAGK CITVGKKPES
       550        560        570        580        590        600
IPGGWGRWSP WSHCSRTCGA GVQSAERLCN NPEPKFGGKY CTGERKRYRL CNVHPCRSEA
       610        620        630        640        650        660
PTFRQMQCSE FDTVPYKNEL YHWFPIFNPA HPCELYCRPI DGQFSEKMLD AVIDGTPCFE
       670        680        690        700        710        720
GGNSRNVCIN GICKMVGCDY EIDSNATEDR CGVCLGDGSS CQTVRKMFKQ KEGSGYVDIG
       730        740        750        760        770        780
LIPKGARDIR VMEIEGAGNF LAIRSEDPEK YYLNGGFIIQ WNGNYKLAGT VFQYDRKGDL
       790        800        810        820        830        840
EKLMATGPTN ESVWIQLLFQ VTNPGIKYEY TIQKDGLDND VEQQMYFWQY GHWTECSVTC
       850        860        870        880        890        900
GTGIRRQTAH CIKKGRGMVK ATFCDPETQP NGRQKKCHEK ACPPRWWAGE WEACSATCGP
       910        920        930        940        950        960
HGEKKRTVLC IQTMVSDEQA LPPTDCQHLL KPKTLLSCNR DILCPSDWTV GNWSECSVSC
       970        980        990       1000       1010       1020
GGGVRIRSVT CAKNHDEPCD VTRKPNSRAL CGLQQCPSSR RVLKPNKGTI SNGKNPPTLK
      1030       1040       1050       1060       1070       1080
PVPPPTSRPR MLTTPTGPES MSTSTPAISS PSPTTASKEG DLGGKQWQDS STQPELSSRY
      1090       1100       1110       1120       1130       1140
LISTGSTSQP ILTSQSLSIQ PSEENVSSSD TGPTSEGGLV ATTTSGSGLS SSRNPITWPV
      1150       1160       1170       1180       1190       1200
TPFYNTLTKG PEMEIHSGSG EEREQPEDKD ESNPVIWTKI RVPGNDAPVE STEMPLAPPL
      1210       1220       1230       1240       1250       1260
TPDLSRESWW PPFSTVMEGL LPSQRPTTSE TGTPRVEGMV TEKPANTLLP LGGDHQPEPS
      1270       1280       1290       1300       1310       1320
GKTANRNHLK LPNNMNQTKS SEPVLTEEDA TSLITEGFLL NASNYKQLTN GHGSAHWIVG
      1330       1340       1350       1360       1370       1380
NWSECSTTCG LGAYWRRVEC STQMDSDCAA IQRPDPAKRC HLRPCAGWKV GNWSKCSRNC
      1390       1400       1410       1420       1430       1440
SGGFKIREIQ CVDSRDHRNL RPFHCQFLAG IPPPLSMSCN PEPCEAWQVE PWSQCSRSCG
      1450       1460       1470       1480       1490       1500
GGVQERGVFC PGGLCDWTKR PTSTMSCNEH LCCHWATGNW DLCSTSCGGG FQKRTVQCVP
      1510       1520       1530       1540       1550       1560
SEGNKTEDQD QCLCDHKPRP PEFKKCNQQA CKKSADLLCT KDKLSASFCQ TLKAMKKCSV
      1570       1580       1590
PTVRAECCFS CPQTHITHTQ RQRRQRLLQK SKEL

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P58397-1-unknown	MPCAQR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67968
P58397-1-unknown	MPCAQR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67969
P58397-26-unknown	YGRQPQ...	26	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P58397-26-unknown	YGRQPQ...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113925
P58397-26-unknown	YGRQPQ...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113926
P58397-83-unknown	DLDGSE...	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9776
P58397-83-unknown	DLDGSE...	83	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141461
P58397-83-unknown	DLDGSE...	83	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141462
P58397-241-unknown	SISKER...	241	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P58397-241-unknown	SISKER...	241	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9779
P58397-241-unknown	SISKER...	241	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116086
P58397-241-unknown	SISKER...	241	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SRRKRD	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9776
...SRRKRD	82	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124635
...SRRKRD	82	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124636
...SLSRRS	240	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9779
...SLSRRS	240	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131498
...KSKEL	1594	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KSKEL	1594	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63587

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
FURIN_HUMAN	82	RKRD.\|.DLDG	inferred from experiment	unknown	MEROPS	Apte SS	Somerville RP et al.:ADAMTS7B, the full-length produ... (S08.071)	15192113,
FURIN_HUMAN	240	SRRS.\|.SISK	inferred from experiment	unknown	MEROPS	Apte SS	Somerville RP et al.:ADAMTS7B, the full-length produ... (S08.071)	15192113,

TopFIND

P58397: A disintegrin and metalloproteinase with thrombospondin motifs 12

General Information

4

N-termini

3

C-termini

2

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates