TopFIND 4.0

P61916: NPC intracellular cholesterol transporter 2 {ECO:0000312|HGNC:HGNC:14537}

General Information

Protein names
- NPC intracellular cholesterol transporter 2 {ECO:0000312|HGNC:HGNC:14537}
- Epididymal secretory protein E1
- Human epididymis-specific protein 1
- He1 {ECO:0000303|PubMed:11125141, ECO:0000303|PubMed:8418812}
- Niemann-Pick disease type C2 protein {ECO:0000303|PubMed:17018531}
Gene names NPC2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P61916

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MRFLAATFLL LALSTAAQAE PVQFKDCGSV DGVIKEVNVS PCPTQPCQLS KGQSYSVNVT 
        70         80         90        100        110        120 
FTSNIQSKSS KAVVHGILMG VPVPFPIPEP DGCKSGINCP IQKDKTYSYL NKLPVKSEYP 
       130        140        150    
SIKLVVEWQL QDDKNQSLFC WEIPVQIVSH L

Isoforms

- Isoform 2 of NPC intracellular cholesterol transporter 2

Sequence View

        10         20         30         40         50         60 
MRFLAATFLL LALSTAAQAE PVQFKDCGSV DGVIKEVNVS PCPTQPCQLS KGQSYSVNVT 
        70         80         90        100        110        120 
FTSNIQSKSS KAVVHGILMG VPVPFPIPEP DGCKSGINCP IQKDKTYSYL NKLPVKSEYP 
       130        140        150    
SIKLVVEWQL QDDKNQSLFC WEIPVQIVSH L



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P61916-20-unknown EPVQFK... 20 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...IVSHL 151 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)