P63000: Ras-related C3 botulinum toxin substrate 1 {ECO:0000305}

General Information

Protein names	- Ras-related C3 botulinum toxin substrate 1 {ECO:0000305} - 3.6.5.2 {ECO:0000269\|PubMed:21565175} - Cell migration-inducing gene 5 protein - Ras-like protein TC25 - p21-Rac1
Gene names	RAC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P63000

4 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG
        70         80         90        100        110        120
QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE VRHHCPNTPI ILVGTKLDLR
       130        140        150        160        170        180
DDKDTIEKLK EKKLTPITYP QGLAMAKEIG AVKYLECSAL TQRGLKTVFD EAIRAVLCPP
       190
PVKKRKRKCL LL

Isoforms

- Isoform B of Ras-related C3 botulinum toxin substrate 1

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P63000-1-unknown	MQAIKC...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P63000-1-unknown	MQAIKC...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86880
P63000-122-unknown	DKDTIE...	122	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1975
P63000-122-unknown	DKDTIE...	122	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144377
P63000-133-unknown	KLTPIT...	133	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164650
P63000-133-	KLTPIT...	133		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P63000-133-	KLTPIT...	133		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LDLRDD	121	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1975
...LDLRDD	121	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127640
...RKRKCL	189	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RKRKCL	189	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91883
...KCLLL	192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82498

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	121	LRDD.\|.DKDT	inferred from experiment	unknown	MEROPS	Cerione RA	Tu S et al.:Cdc42 is a substrate for caspas... (C14.003)	11278572,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)