TopFIND 4.0

P70507: G protein-coupled receptor kinase 4

General Information

Protein names
- G protein-coupled receptor kinase 4
- 2.7.11.16
- G protein-coupled receptor kinase GRK4
Gene names Grk4
Organism Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID P70507

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MELENFMANT LLLKARQGFT KKTGRSKKWR ELLKLPPVSM CSDLRHSIEK DFSSLCDQQP 
        70         80         90        100        110        120 
IGRLLFRQFC NTKPDLKRCI EFLDAAAEYE VTIEEEQREF GLSIYSRFFK ENSEVSLPQI 
       130        140        150        160        170        180 
PPDLVKECKC NLKQSSPSQN VFQDCAGVIY KYLSEKPFEE YQESTYYNRF LQWKWLERRP 
       190        200        210        220        230        240 
VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKKLEKK RIKKRKGEAM ALNEKRILEK 
       250        260        270        280        290        300 
LHSRFVVSLA YTYETKDALC LVLTIMNGGD LKYHIYNLGN PGFEEQRAVF YAAELCCGLE 
       310        320        330        340        350        360 
DLQRERIVYR DLKPENILLD DHGHIRISDL GLALEIPEGE MVRGRVGTVG YMAPEIISHE 
       370        380        390        400        410        420 
KYTFSPDWWG LGCLIYEMIA GHSPFRKYKE KVNREEMERR VKTETEEYSE RFSENAKSIC 
       430        440        450        460        470        480 
SMLLTKDPSK RLGCQSDGAS AVKQHPIFKD INFSRLEANM LDPPFCPDPE AIYCKDILDI 
       490        500        510        520        530        540 
GQFSVVKGVN LDTNDEIFYT QFATGCVTIP WQNEMIESGC FKDLNEYEDK GLSPLEKHKI 
       550        560        570    
CSCILRPKRN FFHRLFRRAA CLNIAHSEER EPTEH

Isoforms

- Isoform GRK4B of G protein-coupled receptor kinase 4

Sequence View

        10         20         30         40         50         60 
MELENFMANT LLLKARQGFT KKTGRSKKWR ELLKLPPVSM CSDLRHSIEK DFSSLCDQQP 
        70         80         90        100        110        120 
IGRLLFRQFC NTKPDLKRCI EFLDAAAEYE VTIEEEQREF GLSIYSRFFK ENSEVSLPQI 
       130        140        150        160        170        180 
PPDLVKECKC NLKQSSPSQN VFQDCAGVIY KYLSEKPFEE YQESTYYNRF LQWKWLERRP 
       190        200        210        220        230        240 
VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKKLEKK RIKKRKGEAM ALNEKRILEK 
       250        260        270        280        290        300 
LHSRFVVSLA YTYETKDALC LVLTIMNGGD LKYHIYNLGN PGFEEQRAVF YAAELCCGLE 
       310        320        330        340        350        360 
DLQRERIVYR DLKPENILLD DHGHIRISDL GLALEIPEGE MVRGRVGTVG YMAPEIISHE 
       370        380        390        400        410        420 
KYTFSPDWWG LGCLIYEMIA GHSPFRKYKE KVNREEMERR VKTETEEYSE RFSENAKSIC 
       430        440        450        460        470        480 
SMLLTKDPSK RLGCQSDGAS AVKQHPIFKD INFSRLEANM LDPPFCPDPE AIYCKDILDI 
       490        500        510        520        530        540 
GQFSVVKGVN LDTNDEIFYT QFATGCVTIP WQNEMIESGC FKDLNEYEDK GLSPLEKHKI 
       550        560        570    
CSCILRPKRN FFHRLFRRAA CLNIAHSEER EPTEH



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Evidence Codes:


Methodology:


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Biological System:


Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P70507-1-Acetylation MELENF... 1 acetylation- inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P70507-1-Acetylation MELENF... 1 acetylation- inferred from isoform by sequence similarity unknown TopFIND inferred from TNt194038
    P70507-1-unknown MELENF... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt192729

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...EPTEH 575 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...EPTEH 575 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt152675

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)