TopFIND 4.0

P78324: Tyrosine-protein phosphatase non-receptor type substrate 1

General Information

Protein names
- Tyrosine-protein phosphatase non-receptor type substrate 1
- SHP substrate 1
- SHPS-1
- Brain Ig-like molecule with tyrosine-based activation motifs
- Bit
- CD172 antigen-like family member A
- Inhibitory receptor SHPS-1
- Macrophage fusion receptor
- MyD-1 antigen
- Signal-regulatory protein alpha-1
- Sirp-alpha-1
- Signal-regulatory protein alpha-2
- Sirp-alpha-2
- Signal-regulatory protein alpha-3
- Sirp-alpha-3
- p84
- CD172a
Gene names SIRPA
Organism Homo sapiens
Protease Family
Protease ID I43.001
Chromosome location
UniProt ID P78324

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MEPAGPAPGR LGPLLCLLLA ASCAWSGVAG EEELQVIQPD KSVLVAAGET ATLRCTATSL 
        70         80         90        100        110        120 
IPVGPIQWFR GAGPGRELIY NQKEGHFPRV TTVSDLTKRN NMDFSIRIGN ITPADAGTYY 
       130        140        150        160        170        180 
CVKFRKGSPD DVEFKSGAGT ELSVRAKPSA PVVSGPAARA TPQHTVSFTC ESHGFSPRDI 
       190        200        210        220        230        240 
TLKWFKNGNE LSDFQTNVDP VGESVSYSIH STAKVVLTRE DVHSQVICEV AHVTLQGDPL 
       250        260        270        280        290        300 
RGTANLSETI RVPPTLEVTQ QPVRAENQVN VTCQVRKFYP QRLQLTWLEN GNVSRTETAS 
       310        320        330        340        350        360 
TVTENKDGTY NWMSWLLVNV SAHRDDVKLT CQVEHDGQPA VSKSHDLKVS AHPKEQGSNT 
       370        380        390        400        410        420 
AAENTGSNER NIYIVVGVVC TLLVALLMAA LYLVRIRQKK AQGSTSSTRL HEPEKNAREI 
       430        440        450        460        470        480 
TQDTNDITYA DLNLPKGKKP APQAAEPNNH TEYASIQTSP QPASEDTLTY ADLDMVHLNR 
       490        500    
TPKQPAPKPE PSFSEYASVQ VPRK

Isoforms

- Isoform 2 of Tyrosine-protein phosphatase non-receptor type substrate 1 - Isoform 4 of Tyrosine-protein phosphatase non-receptor type substrate 1

Sequence View

        10         20         30         40         50         60 
MEPAGPAPGR LGPLLCLLLA ASCAWSGVAG EEELQVIQPD KSVLVAAGET ATLRCTATSL 
        70         80         90        100        110        120 
IPVGPIQWFR GAGPGRELIY NQKEGHFPRV TTVSDLTKRN NMDFSIRIGN ITPADAGTYY 
       130        140        150        160        170        180 
CVKFRKGSPD DVEFKSGAGT ELSVRAKPSA PVVSGPAARA TPQHTVSFTC ESHGFSPRDI 
       190        200        210        220        230        240 
TLKWFKNGNE LSDFQTNVDP VGESVSYSIH STAKVVLTRE DVHSQVICEV AHVTLQGDPL 
       250        260        270        280        290        300 
RGTANLSETI RVPPTLEVTQ QPVRAENQVN VTCQVRKFYP QRLQLTWLEN GNVSRTETAS 
       310        320        330        340        350        360 
TVTENKDGTY NWMSWLLVNV SAHRDDVKLT CQVEHDGQPA VSKSHDLKVS AHPKEQGSNT 
       370        380        390        400        410        420 
AAENTGSNER NIYIVVGVVC TLLVALLMAA LYLVRIRQKK AQGSTSSTRL HEPEKNAREI 
       430        440        450        460        470        480 
TQDTNDITYA DLNLPKGKKP APQAAEPNNH TEYASIQTSP QPASEDTLTY ADLDMVHLNR 
       490        500    
TPKQPAPKPE PSFSEYASVQ VPRK         10         20         30         40         50         60 
MEPAGPAPGR LGPLLCLLLA ASCAWSGVAG EEELQVIQPD KSVLVAAGET ATLRCTATSL 
        70         80         90        100        110        120 
IPVGPIQWFR GAGPGRELIY NQKEGHFPRV TTVSDLTKRN NMDFSIRIGN ITPADAGTYY 
       130        140        150        160        170        180 
CVKFRKGSPD DVEFKSGAGT ELSVRAKPSA PVVSGPAARA TPQHTVSFTC ESHGFSPRDI 
       190        200        210        220        230        240 
TLKWFKNGNE LSDFQTNVDP VGESVSYSIH STAKVVLTRE DVHSQVICEV AHVTLQGDPL 
       250        260        270        280        290        300 
RGTANLSETI RVPPTLEVTQ QPVRAENQVN VTCQVRKFYP QRLQLTWLEN GNVSRTETAS 
       310        320        330        340        350        360 
TVTENKDGTY NWMSWLLVNV SAHRDDVKLT CQVEHDGQPA VSKSHDLKVS AHPKEQGSNT 
       370        380        390        400        410        420 
AAENTGSNER NIYIVVGVVC TLLVALLMAA LYLVRIRQKK AQGSTSSTRL HEPEKNAREI 
       430        440        450        460        470        480 
TQDTNDITYA DLNLPKGKKP APQAAEPNNH TEYASIQTSP QPASEDTLTY ADLDMVHLNR 
       490        500    
TPKQPAPKPE PSFSEYASVQ VPRK



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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)