P78395: Melanoma antigen preferentially expressed in tumors {ECO:0000305}

General Information

Protein names	- Melanoma antigen preferentially expressed in tumors {ECO:0000305} - Opa-interacting protein 4 - OIP-4 - Preferentially expressed antigen of melanoma
Gene names	PRAME
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P78395

2 N-termini

7 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MERRRLWGSI QSRYISMSVW TSPRRLVELA GQSLLKDEAL AIAALELLPR ELFPPLFMAA
        70         80         90        100        110        120
FDGRHSQTLK AMVQAWPFTC LPLGVLMKGQ HLHLETFKAV LDGLDVLLAQ EVRPRRWKLQ
       130        140        150        160        170        180
VLDLRKNSHQ DFWTVWSGNR ASLYSFPEPE AAQPMTKKRK VDGLSTEAEQ PFIPVEVLVD
       190        200        210        220        230        240
LFLKEGACDE LFSYLIEKVK RKKNVLRLCC KKLKIFAMPM QDIKMILKMV QLDSIEDLEV
       250        260        270        280        290        300
TCTWKLPTLA KFSPYLGQMI NLRRLLLSHI HASSYISPEK EEQYIAQFTS QFLSLQCLQA
       310        320        330        340        350        360
LYVDSLFFLR GRLDQLLRHV MNPLETLSIT NCRLSEGDVM HLSQSPSVSQ LSVLSLSGVM
       370        380        390        400        410        420
LTDVSPEPLQ ALLERASATL QDLVFDECGI TDDQLLALLP SLSHCSQLTT LSFYGNSISI
       430        440        450        460        470        480
SALQSLLQHL IGLSNLTHVL YPVPLESYED IHGTLHLERL AYLHARLREL LCELGRPSMV
       490        500
WLSANPCPHC GDRTFYDPEP ILCPCFMPN

Isoforms

Sequence View

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 7 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P78395-1-unknown	MERRRL...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P78395-17-unknown	MSVWTS...	17	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000445097
P78395-17-unknown	MSVWTS...	17	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000407342

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...PLGVLM	86	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000385091
...EVRPRR	115	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000384058
...EPEAAQ	152	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000412318
...VDGLST	165	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000407121
...EKVKRK	201	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000407320
...CFMPN	509	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...CFMPN	509		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...CFMPN	509		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)