P84022: Mothers against decapentaplegic homolog 3

General Information

Protein names	- Mothers against decapentaplegic homolog 3 - MAD homolog 3 - Mad3 - Mothers against DPP homolog 3 - hMAD-3 - JV15-2 - SMAD family member 3 - SMAD 3 - Smad3 - hSMAD3
Gene names	SMAD3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P84022

6 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Mothers against decapentaplegic homolog 3 - Isoform 3 of Mothers against decapentaplegic homolog 3 - Isoform 4 of Mothers against decapentaplegic homolog 3

Sequence View

        10         20         30         40         50         60
MSSILPFTPP IVKRLLGWKK GEQNGQEEKW CEKAVKSLVK KLKKTGQLDE LEKAITTQNV
        70         80         90        100        110        120
NTKCITIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH HELRAMELCE FAFNMKKDEV
       130        140        150        160        170        180
CVNPYHYQRV ETPVLPPVLV PRHTEIPAEF PPLDDYSHSI PENTNFPAGI EPQSNIPETP
       190        200        210        220        230        240
PPGYLSEDGE TSDHQMNHSM DAGSPNLSPN PMSPAHNNLD LQPVTYCEPA FWCSISYYEL
       250        260        270        280        290        300
NQRVGETFHA SQPSMTVDGF TDPSNSERFC LGLLSNVNRN AAVELTRRHI GRGVRLYYIG
       310        320        330        340        350        360
GEVFAECLSD SAIFVQSPNC NQRYGWHPAT VCKIPPGCNL KIFNNQEFAA LLAQSVNQGF
       370        380        390        400        410        420
EAVYQLTRMC TIRMSFVKGW GAEYRRQTVT STPCWIELHL NGPLQWLDKV LTQMGSPSIR

CSSVS         10         20         30         40         50         60
MSSILPFTPP IVKRLLGWKK GEQNGQEEKW CEKAVKSLVK KLKKTGQLDE LEKAITTQNV
        70         80         90        100        110        120
NTKCITIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH HELRAMELCE FAFNMKKDEV
       130        140        150        160        170        180
CVNPYHYQRV ETPVLPPVLV PRHTEIPAEF PPLDDYSHSI PENTNFPAGI EPQSNIPETP
       190        200        210        220        230        240
PPGYLSEDGE TSDHQMNHSM DAGSPNLSPN PMSPAHNNLD LQPVTYCEPA FWCSISYYEL
       250        260        270        280        290        300
NQRVGETFHA SQPSMTVDGF TDPSNSERFC LGLLSNVNRN AAVELTRRHI GRGVRLYYIG
       310        320        330        340        350        360
GEVFAECLSD SAIFVQSPNC NQRYGWHPAT VCKIPPGCNL KIFNNQEFAA LLAQSVNQGF
       370        380        390        400        410        420
EAVYQLTRMC TIRMSFVKGW GAEYRRQTVT STPCWIELHL NGPLQWLDKV LTQMGSPSIR

CSSVS         10         20         30         40         50         60
MSSILPFTPP IVKRLLGWKK GEQNGQEEKW CEKAVKSLVK KLKKTGQLDE LEKAITTQNV
        70         80         90        100        110        120
NTKCITIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH HELRAMELCE FAFNMKKDEV
       130        140        150        160        170        180
CVNPYHYQRV ETPVLPPVLV PRHTEIPAEF PPLDDYSHSI PENTNFPAGI EPQSNIPETP
       190        200        210        220        230        240
PPGYLSEDGE TSDHQMNHSM DAGSPNLSPN PMSPAHNNLD LQPVTYCEPA FWCSISYYEL
       250        260        270        280        290        300
NQRVGETFHA SQPSMTVDGF TDPSNSERFC LGLLSNVNRN AAVELTRRHI GRGVRLYYIG
       310        320        330        340        350        360
GEVFAECLSD SAIFVQSPNC NQRYGWHPAT VCKIPPGCNL KIFNNQEFAA LLAQSVNQGF
       370        380        390        400        410        420
EAVYQLTRMC TIRMSFVKGW GAEYRRQTVT STPCWIELHL NGPLQWLDKV LTQMGSPSIR

CSSVS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P84022-2-unknown	MSSILP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P84022-2-Acetylation	SSILPF...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P84022-2-Acetylation	SSILPF...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P84022-106-unknown	MELCEF...	106		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt89979
P84022-106-unknown	MELCEF...	106		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt102899
P84022-196-unknown	MNHSMD...	196		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt89980
P84022-196-unknown	MNHSMD...	196		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt102956
P84022-196-unknown	MNHSMD...	196		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt102957
P84022-259-unknown	GFTDPS...	259		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176194
P84022-259-unknown	GFTDPS...	259		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176195
P84022-259-unknown	GFTDPS...	259		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176196
P84022-259-	GFTDPS...	259			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P84022-259-	GFTDPS...	259			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...CSSVS	425	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...CSSVS	425	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85598
...CSSVS	425	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85597
...CSSVS	425	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85596

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)