P97807: Fumarate hydratase, mitochondrial {ECO:0000303|PubMed:17418408}

General Information

Protein names	- Fumarate hydratase, mitochondrial {ECO:0000303\|PubMed:17418408} - Fumarase {ECO:0000303\|PubMed:9032278} - 4.2.1.2 {ECO:0000305\|PubMed:23643539} - EF-3
Gene names	Fh
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P97807

5 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MYRALRLLAR SRRLLRVPSA GAAVSGEATT LPRCAPNVAR MASQNSFRVE FDTFGELKVP
        70         80         90        100        110        120
TDKYYGAQTV RSTMNFKIGG ATERMPIPVI QAFGILKRAA AEVNQEYGLD PKIASAIMKA
       130        140        150        160        170        180
ADEVAEGKLN DHFPLVVWQT GSGTQTNMNV NEVISNRAIE MLGGELGSKK PVHPNDHVNK
       190        200        210        220        230        240
SQSSNDTFPT AMHIAAAVEV HKVLLPGLQK LHDALSAKSK EFAQVIKIGR THTQDAVPLT
       250        260        270        280        290        300
LGQEFSGYVQ QVQYAMVRIK AAMPRIYELA AGGTAVGTGL NTRIGFAEKV AAKVAALTGL
       310        320        330        340        350        360
PFVTAPNKFE ALAAHDALVE LSGAMNTAAC SLMKIANDIR FLGSGPRSGL GELILPENEP
       370        380        390        400        410        420
GSSIMPGKVN PTQCEAMTMV AAQVMGNHVA VTVGGSNGHF ELNVFKPMMI KNVLHSARLL
       430        440        450        460        470        480
GDASVSFTDN CVVGIQANTE RINKLMNESL MLVTALNPHI GYDKAAKIAK TAHKNGSTLK
       490        500
ETAIELGYLT AEQFDEWVKP KDMLGPK

Isoforms

- Isoform Cytoplasmic of Fumarate hydratase, mitochondrial

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P97807-41-unknown	MASQNS...	41	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75540
P97807-42-unknown	ASQNSF...	42	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P97807-42-unknown	ASQNSF...	42	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115459
P97807-42-unknown	ASQNSF...	42	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P97807-149-unknown	NVNEVI...	149	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30365
P97807-149-unknown	NVNEVI...	149	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142887
P97807-223-unknown	AQVIKI...	223	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30367
P97807-223-unknown	AQVIKI...	223	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146007
P97807-270-unknown	AAGGTA...	270	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30369
P97807-270-unknown	AAGGTA...	270	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147745

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TQTNMN	148	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30365
...TQTNMN	148	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126096
...KSKEFA	222	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30367
...KSKEFA	222	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129306
...RIYELA	269	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30369
...RIYELA	269	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131100
...MLGPK	507	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...MLGPK	507	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71158

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Evidence name
CATE_MOUSE	148	TNMN.\|.NVNE	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> FUMH_MOUSE @148
CATE_MOUSE	222	KEFA.\|.AQVI	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> FUMH_MOUSE @222
CATE_MOUSE	269	YELA.\|.AAGG	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> FUMH_MOUSE @269

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)