TopFIND 4.0

P98064: Mannan-binding lectin serine protease 1

General Information

Protein names
- Mannan-binding lectin serine protease 1
- 3.4.21.-
- Complement factor MASP-3
- Complement-activating component of Ra-reactive factor
- Mannose-binding lectin-associated serine protease 1
- MASP-1
- Mannose-binding protein-associated serine protease
- Ra-reactive factor serine protease p100
- RaRF
- Serine protease 5
- Mannan-binding lectin serine protease 1 heavy chain
- Mannan-binding lectin serine protease 1 light chain
Gene names Masp1
Organism Mus musculus
Protease Family
Protease ID S01.132
Chromosome location
UniProt ID P98064

3

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MRFLSFWRLL LYHALCLALP EVSAHTVELN EMFGQIQSPG YPDSYPSDSE VTWNITVPEG 
        70         80         90        100        110        120 
FRIKLYFMHF NLESSYLCEY DYVKVETEDQ VLATFCGRET TDTEQTPGQE VVLSPGTFMS 
       130        140        150        160        170        180 
VTFRSDFSNE ERFTGFDAHY MAVDVDECKE REDEELSCDH YCHNYIGGYY CSCRFGYILH 
       190        200        210        220        230        240 
TDNRTCRVEC SGNLFTQRTG TITSPDYPNP YPKSSECSYT IDLEEGFMVS LQFEDIFDIE 
       250        260        270        280        290        300 
DHPEVPCPYD YIKIKAGSKV WGPFCGEKSP EPISTQTHSV QILFRSDNSG ENRGWRLSYR 
       310        320        330        340        350        360 
AAGNECPKLQ PPVYGKIEPS QAVYSFKDQV LVSCDTGYKV LKDNEVMDTF QIECLKDGAW 
       370        380        390        400        410        420 
SNKIPTCKIV DCGAPAGLKH GLVTFSTRNN LTTYKSEIRY SCQQPYYKML HNTTGVYTCS 
       430        440        450        460        470        480 
AHGTWTNEVL KRSLPTCLPV CGVPKFSRKQ ISRIFNGRPA QKGTMPWIAM LSHLNGQPFC 
       490        500        510        520        530        540 
GGSLLGSNWV LTAAHCLHQS LDPEEPTLHS SYLLSPSDFK IIMGKHWRRR SDEDEQHLHV 
       550        560        570        580        590        600 
KRTTLHPLYN PSTFENDLGL VELSESPRLN DFVMPVCLPE QPSTEGTMVI VSGWGKQFLQ 
       610        620        630        640        650        660 
RFPENLMEIE IPIVNSDTCQ EAYTPLKKKV TKDMICAGEK EGGKDACAGD SGGPMVTKDA 
       670        680        690        700    
ERDQWYLVGV VSWGEDCGKK DRYGVYSYIY PNKDWIQRIT GVRN

Isoforms

- Isoform 2 of Mannan-binding lectin serine protease 1

Sequence View

        10         20         30         40         50         60 
MRFLSFWRLL LYHALCLALP EVSAHTVELN EMFGQIQSPG YPDSYPSDSE VTWNITVPEG 
        70         80         90        100        110        120 
FRIKLYFMHF NLESSYLCEY DYVKVETEDQ VLATFCGRET TDTEQTPGQE VVLSPGTFMS 
       130        140        150        160        170        180 
VTFRSDFSNE ERFTGFDAHY MAVDVDECKE REDEELSCDH YCHNYIGGYY CSCRFGYILH 
       190        200        210        220        230        240 
TDNRTCRVEC SGNLFTQRTG TITSPDYPNP YPKSSECSYT IDLEEGFMVS LQFEDIFDIE 
       250        260        270        280        290        300 
DHPEVPCPYD YIKIKAGSKV WGPFCGEKSP EPISTQTHSV QILFRSDNSG ENRGWRLSYR 
       310        320        330        340        350        360 
AAGNECPKLQ PPVYGKIEPS QAVYSFKDQV LVSCDTGYKV LKDNEVMDTF QIECLKDGAW 
       370        380        390        400        410        420 
SNKIPTCKIV DCGAPAGLKH GLVTFSTRNN LTTYKSEIRY SCQQPYYKML HNTTGVYTCS 
       430        440        450        460        470        480 
AHGTWTNEVL KRSLPTCLPV CGVPKFSRKQ ISRIFNGRPA QKGTMPWIAM LSHLNGQPFC 
       490        500        510        520        530        540 
GGSLLGSNWV LTAAHCLHQS LDPEEPTLHS SYLLSPSDFK IIMGKHWRRR SDEDEQHLHV 
       550        560        570        580        590        600 
KRTTLHPLYN PSTFENDLGL VELSESPRLN DFVMPVCLPE QPSTEGTMVI VSGWGKQFLQ 
       610        620        630        640        650        660 
RFPENLMEIE IPIVNSDTCQ EAYTPLKKKV TKDMICAGEK EGGKDACAGD SGGPMVTKDA 
       670        680        690        700    
ERDQWYLVGV VSWGEDCGKK DRYGVYSYIY PNKDWIQRIT GVRN



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


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Lab:



Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P98064-1-unknown MRFLSF... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt80455
    P98064-25-unknown HTVELN... 25 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P98064-25-unknown HTVELN... 25 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt113724
    P98064-454-unknown IFNGRP... 454 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...KQISRI 453 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...TGVRN 704 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)